Gene: ENSG00000101916 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000101916
Transcript Identifier
ENST00000311912
Gene Type
Coding gene
Location
X : 12910386-12922166 : positive

Family Information

Homologous gene family
HOM03P004593
(20 genes in 3 species)
specific family
Orthologous gene family
ORTHO03P044944
(2 genes in 1 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
toll-like receptor 8

Identifiers

Type Value
pidENSP00000312082
HGNC15632
UniprotQ9NR97

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001774
IEA
Genome Projectmicroglial cell activation
GO:0001932
IEA
Genome Projectregulation of protein phosphorylation
GO:0002224
TAS, IEA
Genome Projecttoll-like receptor signaling pathway
GO:0002376
IEA
Genome Projectimmune system process
GO:0002755
IEA
Genome ProjectMyD88-dependent toll-like receptor signaling pathway
GO:0006954
IEA
Genome Projectinflammatory response
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007249
IDA
Genome ProjectI-kappaB kinase/NF-kappaB signaling
GO:0009615
IDA
Genome Projectresponse to virus
GO:0016064
TAS
Genome Projectimmunoglobulin mediated immune response
GO:0034158
IEA
Genome Projecttoll-like receptor 8 signaling pathway
GO:0034162
TAS
Genome Projecttoll-like receptor 9 signaling pathway
GO:0045078
IDA
Genome Projectpositive regulation of interferon-gamma biosynthetic process
GO:0045087
TAS, NAS, IEA
Genome Projectinnate immune response
GO:0045089
IDA
IEA
Genome Projectpositive regulation of innate immune response
GO:0045356
IDA
Genome Projectpositive regulation of interferon-alpha biosynthetic process
GO:0045359
IDA
Genome Projectpositive regulation of interferon-beta biosynthetic process
GO:0045416
IMP
Genome Projectpositive regulation of interleukin-8 biosynthetic process
GO:0050707
IEA
Genome Projectregulation of cytokine secretion
GO:0051607
IMP
IEA
Genome Projectdefense response to virus
GO:0071260
IEP
Genome Projectcellular response to mechanical stimulus

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003677
IDA
IEA
Genome ProjectDNA binding
GO:0003723
TAS
Genome ProjectRNA binding
GO:0003725
IDA
IEA
Genome Projectdouble-stranded RNA binding
GO:0003727
IDA
IEA
Genome Projectsingle-stranded RNA binding
GO:0004872
NAS
Genome Projectreceptor activity
GO:0008144
IEA
Genome Projectdrug binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000139
TAS
Genome ProjectGolgi membrane
GO:0005789
TAS
Genome Projectendoplasmic reticulum membrane
GO:0010008
TAS
Genome Projectendosome membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IC, IEA
Genome Projectintegral component of membrane
GO:0036020
TAS
Genome Projectendolysosome membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000157Toll/interleukin-1 receptor homology (TIR) domain
IPR000483Cysteine-rich flanking region, C-terminal
IPR001611Leucine-rich repeat
IPR003591Leucine-rich repeat, typical subtype
IPR027175Toll-like receptor 8

No MapMan annotations defined for this gene.