Gene: ENSG00000101412 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000101412
Transcript Identifier
ENST00000343380
Gene Type
Coding gene
Location
20 : 33676732-33686264 : negative

Family Information

Homologous gene family
HOM03P001060
(60 genes in 35 species)
specific family
Orthologous gene family
ORTHO03P067667
(2 genes in 2 species)
specific family

Descriptions

gene_descr
E2F transcription factor 1

Identifiers

Type Value
pidENSP00000345571
HGNC3113
UniprotQ01094

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000077
IMP
Genome ProjectDNA damage checkpoint
GO:0000082
TAS
Genome ProjectG1/S transition of mitotic cell cycle
GO:0000122
IMP
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0000278
TAS
Genome Projectmitotic cell cycle
GO:0006351
ISS
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IDA
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006915
TAS, IEA
Genome Projectapoptotic process
GO:0007049
IEA
Genome Projectcell cycle
GO:0007219
TAS
Genome ProjectNotch signaling pathway
GO:0007283
IEA
Genome Projectspermatogenesis
GO:0008630
IMP
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage
GO:0010628
IDA
Genome Projectpositive regulation of gene expression
GO:0012501
TAS
Genome Projectprogrammed cell death
GO:0030900
IEA
Genome Projectforebrain development
GO:0043276
IEA
Genome Projectanoikis
GO:0043392
IDA
Genome Projectnegative regulation of DNA binding
GO:0045599
ISS
IEA
Genome Projectnegative regulation of fat cell differentiation
GO:0045892
IDA, IMP
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IDA, IMP
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IMP
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048146
IMP
Genome Projectpositive regulation of fibroblast proliferation
GO:0048255
IDA
Genome ProjectmRNA stabilization
GO:0051726
IEA
Genome Projectregulation of cell cycle
GO:0070345
ISS
IEA
Genome Projectnegative regulation of fat cell proliferation
GO:0071398
IEA
Genome Projectcellular response to fatty acid
GO:0071456
IEA
Genome Projectcellular response to hypoxia
GO:0071466
IEA
Genome Projectcellular response to xenobiotic stimulus
GO:0071930
IMP
Genome Projectnegative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0072332
IEA
Genome Projectintrinsic apoptotic signaling pathway by p53 class mediator
GO:0097193
TAS
Genome Projectintrinsic apoptotic signaling pathway
GO:1900740
TAS
Genome Projectpositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1990086
IEA
Genome Projectlens fiber cell apoptotic process
GO:1990090
IEA
Genome Projectcellular response to nerve growth factor stimulus
GO:2000045
IMP
Genome Projectregulation of G1/S transition of mitotic cell cycle

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001047
IDA
Genome Projectcore promoter binding
GO:0003677
IDA, IMP
IEA
Genome ProjectDNA binding
GO:0003700
IDA
TAS, IEA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008134
IPI
Genome Projecttranscription factor binding
GO:0019901
IEA
Genome Projectprotein kinase binding
GO:0043565
ISS
IEA
Genome Projectsequence-specific DNA binding
GO:0044212
IEA
Genome Projecttranscription regulatory region DNA binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005667
IEA
Genome Projecttranscription factor complex
GO:0005737
IEA
Genome Projectcytoplasm
GO:0035189
IDA
Genome ProjectRb-E2F complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003316E2F/DP family, winged-helix DNA-binding domain
IPR011991Winged helix-turn-helix DNA-binding domain
IPR015633E2F Family
IPR032198E2F transcription factor, CC-MB domain

No MapMan annotations defined for this gene.