Gene: ENSG00000101109 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000101109
Transcript Identifier
ENST00000372806
Gene Type
Coding gene
Location
20 : 44966569-45075176 : positive

Family Information

Homologous gene family
HOM03P000001
(4368 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P001395
(38 genes in 28 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
serine/threonine kinase 4

Identifiers

Type Value
pidENSP00000361892
HGNC11408
UniprotQ13043

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000165
IBA
Genome ProjectMAPK cascade
GO:0000186
IBA
Genome Projectactivation of MAPKK activity
GO:0000902
IDA
Genome Projectcell morphogenesis
GO:0001569
IEA
Genome Projectpatterning of blood vessels
GO:0001841
IEA
Genome Projectneural tube formation
GO:0001934
IDA
Genome Projectpositive regulation of protein phosphorylation
GO:0003157
IEA
Genome Projectendocardium development
GO:0006468
IDA
IEA
Genome Projectprotein phosphorylation
GO:0006915
IDA
IEA
Genome Projectapoptotic process
GO:0007165
TAS, IEA
Genome Projectsignal transduction
GO:0007346
IBA
Genome Projectregulation of mitotic cell cycle
GO:0007417
IEA
Genome Projectcentral nervous system development
GO:0008285
IEA
Genome Projectnegative regulation of cell proliferation
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018105
IDA
Genome Projectpeptidyl-serine phosphorylation
GO:0023014
IBA
Genome Projectsignal transduction by protein phosphorylation
GO:0030216
IEA
Genome Projectkeratinocyte differentiation
GO:0031098
IBA
Genome Projectstress-activated protein kinase signaling cascade
GO:0032092
IDA
Genome Projectpositive regulation of protein binding
GO:0033138
IDA
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0035329
IDA
TAS
Genome Projecthippo signaling
GO:0035556
IDA
Genome Projectintracellular signal transduction
GO:0043065
IDA
Genome Projectpositive regulation of apoptotic process
GO:0045600
IEA
Genome Projectpositive regulation of fat cell differentiation
GO:0046621
IEA
Genome Projectnegative regulation of organ growth
GO:0046777
IDA
Genome Projectprotein autophosphorylation
GO:0050821
IDA
Genome Projectprotein stabilization
GO:0060215
IEA
Genome Projectprimitive hemopoiesis
GO:0060706
IEA
Genome Projectcell differentiation involved in embryonic placenta development
GO:0060800
IEA
Genome Projectregulation of cell differentiation involved in embryonic placenta development
GO:0071902
TAS
Genome Projectpositive regulation of protein serine/threonine kinase activity
GO:0090090
IMP
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:0097284
IEA
Genome Projecthepatocyte apoptotic process
GO:1902043
IEA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0000287
IDA
Genome Projectmagnesium ion binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004674
EXP, IDA
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004709
IBA
Genome ProjectMAP kinase kinase kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IDA
IEA
Genome ProjectATP binding
GO:0008134
IPI
Genome Projecttranscription factor binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042803
IDA
Genome Projectprotein homodimerization activity
GO:0043539
TAS
Genome Projectprotein serine/threonine kinase activator activity
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0046983
IDA
Genome Projectprotein dimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
IDA
Genome Projectnucleoplasm
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005829
TAS
Genome Projectcytosol
GO:0043234
IDA
Genome Projectprotein complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR002290Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009Protein kinase-like domain
IPR011524SARAH domain
IPR017441Protein kinase, ATP binding site
IPR024205Mst1 SARAH domain

No MapMan annotations defined for this gene.