Gene: ENSG00000100906 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000100906
Transcript Identifier
ENST00000216797
Gene Type
Coding gene
Location
14 : 35402013-35404644 : negative

Family Information

Homologous gene family
HOM03P000010
(1560 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P042840
(3 genes in 3 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

Identifiers

Type Value
pidENSP00000216797
HGNC7797
UniprotP25963

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000060
IEA
Genome Projectprotein import into nucleus, translocation
GO:0002223
TAS
Genome Projectstimulatory C-type lectin receptor signaling pathway
GO:0002224
TAS
Genome Projecttoll-like receptor signaling pathway
GO:0002755
TAS
Genome ProjectMyD88-dependent toll-like receptor signaling pathway
GO:0002756
TAS
Genome ProjectMyD88-independent toll-like receptor signaling pathway
GO:0006915
TAS
Genome Projectapoptotic process
GO:0007253
IMP
IEA
Genome Projectcytoplasmic sequestering of NF-kappaB
GO:0010468
IEA
Genome Projectregulation of gene expression
GO:0010745
IMP
Genome Projectnegative regulation of macrophage derived foam cell differentiation
GO:0010875
IMP
Genome Projectpositive regulation of cholesterol efflux
GO:0010888
IMP
Genome Projectnegative regulation of lipid storage
GO:0016032
IEA
Genome Projectviral process
GO:0031663
IEA
Genome Projectlipopolysaccharide-mediated signaling pathway
GO:0032088
IDA
Genome Projectnegative regulation of NF-kappaB transcription factor activity
GO:0032270
IMP
Genome Projectpositive regulation of cellular protein metabolic process
GO:0032481
TAS
Genome Projectpositive regulation of type I interferon production
GO:0032495
IEA
Genome Projectresponse to muramyl dipeptide
GO:0032496
IEA
Genome Projectresponse to lipopolysaccharide
GO:0034134
TAS
Genome Projecttoll-like receptor 2 signaling pathway
GO:0034138
TAS
Genome Projecttoll-like receptor 3 signaling pathway
GO:0034142
TAS, IEA
Genome Projecttoll-like receptor 4 signaling pathway
GO:0034146
TAS
Genome Projecttoll-like receptor 5 signaling pathway
GO:0034162
TAS
Genome Projecttoll-like receptor 9 signaling pathway
GO:0034166
TAS
Genome Projecttoll-like receptor 10 signaling pathway
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0035994
IEA
Genome Projectresponse to muscle stretch
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0038123
TAS
Genome Projecttoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124
TAS
Genome Projecttoll-like receptor TLR6:TLR2 signaling pathway
GO:0042127
IEA
Genome Projectregulation of cell proliferation
GO:0042345
NAS
Genome Projectregulation of NF-kappaB import into nucleus
GO:0042994
IDA
TAS
Genome Projectcytoplasmic sequestering of transcription factor
GO:0043066
TAS
Genome Projectnegative regulation of apoptotic process
GO:0043330
IEA
Genome Projectresponse to exogenous dsRNA
GO:0043392
NAS
Genome Projectnegative regulation of DNA binding
GO:0045087
TAS
Genome Projectinnate immune response
GO:0045638
IEA
Genome Projectnegative regulation of myeloid cell differentiation
GO:0045746
IEA
Genome Projectnegative regulation of Notch signaling pathway
GO:0045893
IEA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA, IMP
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0050852
TAS
Genome ProjectT cell receptor signaling pathway
GO:0051092
TAS
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0070417
NAS
Genome Projectcellular response to cold
GO:0070427
IEA
Genome Projectnucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431
IEA
Genome Projectnucleotide-binding oligomerization domain containing 2 signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005515
IPI
Genome Projectprotein binding
GO:0008134
TAS
Genome Projecttranscription factor binding
GO:0008139
IPI
Genome Projectnuclear localization sequence binding
GO:0019899
IPI
Genome Projectenzyme binding
GO:0031072
IEA
Genome Projectheat shock protein binding
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0032403
IEA
Genome Projectprotein complex binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0051059
IDA, IPI
IEA
Genome ProjectNF-kappaB binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005829
TAS, IEA
Genome Projectcytosol
GO:0005886
IDA
Genome Projectplasma membrane
GO:0033256
TAS
Genome ProjectI-kappaB/NF-kappaB complex
GO:0043234
IEA
Genome Projectprotein complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR002110Ankyrin repeat
IPR020683Ankyrin repeat-containing domain

No MapMan annotations defined for this gene.