Gene: ENSG00000100697 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000100697
Transcript Identifier
ENST00000527414
Gene Type
Coding gene
Location
14 : 95090498-95133458 : negative

Family Information

Homologous gene family
HOM03P000904
(66 genes in 21 species)
specific family
Orthologous gene family
ORTHO03P027247
(4 genes in 4 species)
specific family

Descriptions

gene_descr
dicer 1, ribonuclease type III

Identifiers

Type Value
pidENSP00000435681
HGNC17098
UniprotQ9UPY3

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
ISS
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001525
IEA
Genome Projectangiogenesis
GO:0001942
IEA
Genome Projecthair follicle development
GO:0006309
IBA
Genome Projectapoptotic DNA fragmentation
GO:0006396
IEA
Genome ProjectRNA processing
GO:0008283
IEA
Genome Projectcell proliferation
GO:0009791
IEA
Genome Projectpost-embryonic development
GO:0010070
IEA
Genome Projectzygote asymmetric cell division
GO:0010467
TAS
Genome Projectgene expression
GO:0010468
IEA
Genome Projectregulation of gene expression
GO:0010626
ISS
Genome Projectnegative regulation of Schwann cell proliferation
GO:0010628
IEA
Genome Projectpositive regulation of gene expression
GO:0010660
IEA
Genome Projectregulation of muscle cell apoptotic process
GO:0014040
ISS
Genome Projectpositive regulation of Schwann cell differentiation
GO:0014835
IEA
Genome Projectmyoblast differentiation involved in skeletal muscle regeneration
GO:0019827
IEA
Genome Projectstem cell population maintenance
GO:0021522
IEA
Genome Projectspinal cord motor neuron differentiation
GO:0021675
ISS
Genome Projectnerve development
GO:0021889
IEA
Genome Projectolfactory bulb interneuron differentiation
GO:0021987
IEA
Genome Projectcerebral cortex development
GO:0030324
IEA
Genome Projectlung development
GO:0030326
IEA
Genome Projectembryonic limb morphogenesis
GO:0030422
IDA
Genome Projectproduction of siRNA involved in RNA interference
GO:0030423
IMP
Genome Projecttargeting of mRNA for destruction involved in RNA interference
GO:0031047
IEA
Genome Projectgene silencing by RNA
GO:0031054
IDA
Genome Projectpre-miRNA processing
GO:0031069
IEA
Genome Projecthair follicle morphogenesis
GO:0031641
IEA
Genome Projectregulation of myelination
GO:0031643
ISS
IEA
Genome Projectpositive regulation of myelination
GO:0032290
ISS
Genome Projectperipheral nervous system myelin formation
GO:0033168
IMP
Genome Projectconversion of ds siRNA to ss siRNA involved in RNA interference
GO:0035087
IDA
Genome ProjectsiRNA loading onto RISC involved in RNA interference
GO:0035116
IEA
Genome Projectembryonic hindlimb morphogenesis
GO:0035196
IDA
ISS
Genome Projectproduction of miRNAs involved in gene silencing by miRNA
GO:0035264
IEA
Genome Projectmulticellular organism growth
GO:0035280
IDA
Genome ProjectmiRNA loading onto RISC involved in gene silencing by miRNA
GO:0036404
IMP
Genome Projectconversion of ds siRNA to ss siRNA
GO:0042487
IEA
Genome Projectregulation of odontogenesis of dentin-containing tooth
GO:0045069
IEA
Genome Projectregulation of viral genome replication
GO:0045595
IEA
Genome Projectregulation of cell differentiation
GO:0045664
IEA
Genome Projectregulation of neuron differentiation
GO:0048255
IEA
Genome ProjectmRNA stabilization
GO:0048536
IEA
Genome Projectspleen development
GO:0048565
IEA
Genome Projectdigestive tract development
GO:0048608
IEA
Genome Projectreproductive structure development
GO:0048713
IEA
Genome Projectregulation of oligodendrocyte differentiation
GO:0048730
IEA
Genome Projectepidermis morphogenesis
GO:0048754
IEA
Genome Projectbranching morphogenesis of an epithelial tube
GO:0048812
ISS
Genome Projectneuron projection morphogenesis
GO:0048856
IEA
Genome Projectanatomical structure development
GO:0050767
IEA
Genome Projectregulation of neurogenesis
GO:0051216
IEA
Genome Projectcartilage development
GO:0051225
IEA
Genome Projectspindle assembly
GO:0051252
IEA
Genome Projectregulation of RNA metabolic process
GO:0051607
IEA
Genome Projectdefense response to virus
GO:0051726
IEA
Genome Projectregulation of cell cycle
GO:0055013
IEA
Genome Projectcardiac muscle cell development
GO:0060119
IEA
Genome Projectinner ear receptor cell development
GO:0060253
IEA
Genome Projectnegative regulation of glial cell proliferation
GO:0060576
IEA
Genome Projectintestinal epithelial cell development
GO:0061309
IEA
Genome Projectcardiac neural crest cell development involved in outflow tract morphogenesis
GO:0061548
IEA
Genome Projectganglion development
GO:0070173
IEA
Genome Projectregulation of enamel mineralization
GO:0071335
IEA
Genome Projecthair follicle cell proliferation
GO:0090502
IDA
Genome ProjectRNA phosphodiester bond hydrolysis, endonucleolytic
GO:2000628
IEA
Genome Projectregulation of miRNA metabolic process
GO:2000630
IEA
Genome Projectpositive regulation of miRNA metabolic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0003677
IEA
Genome ProjectDNA binding
GO:0003723
IEA
Genome ProjectRNA binding
GO:0003725
IDA, IMP
Genome Projectdouble-stranded RNA binding
GO:0004386
IEA
Genome Projecthelicase activity
GO:0004518
IEA
Genome Projectnuclease activity
GO:0004519
IEA
Genome Projectendonuclease activity
GO:0004521
IDA, IMP
Genome Projectendoribonuclease activity
GO:0004525
IDA
IEA
Genome Projectribonuclease III activity
GO:0004530
IBA
Genome Projectdeoxyribonuclease I activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0016891
IEA
Genome Projectendoribonuclease activity, producing 5'-phosphomonoesters
GO:0019904
IPI
Genome Projectprotein domain specific binding
GO:0035197
IDA
Genome ProjectsiRNA binding
GO:0035198
IEA
Genome ProjectmiRNA binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0070883
IDA
Genome Projectpre-miRNA binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IBA
Genome Projectnucleus
GO:0005737
IBA
IEA
Genome Projectcytoplasm
GO:0005793
IEA
Genome Projectendoplasmic reticulum-Golgi intermediate compartment
GO:0005829
TAS
Genome Projectcytosol
GO:0030424
IEA
Genome Projectaxon
GO:0030425
IEA
Genome Projectdendrite
GO:0030426
IEA
Genome Projectgrowth cone
GO:0033167
IC
Genome ProjectARC complex
GO:0035068
IEA
Genome Projectmicro-ribonucleoprotein complex
GO:0070578
IDA
Genome ProjectRISC-loading complex
GO:0016442
IDA
Genome ProjectRISC complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000999Ribonuclease III domain
IPR001650Helicase, C-terminal
IPR003100PAZ domain
IPR005034Dicer dimerisation domain
IPR006935Helicase/UvrB, N-terminal
IPR014001Helicase superfamily 1/2, ATP-binding domain
IPR014720Double-stranded RNA-binding domain
IPR027417P-loop containing nucleoside triphosphate hydrolase

No MapMan annotations defined for this gene.