Gene: ENSG00000100453 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000100453
Transcript Identifier
ENST00000216341
Gene Type
Coding gene
Location
14 : 24631071-24634160 : negative

Family Information

Homologous gene family
HOM03P000033
(649 genes in 22 species)
specific family
Orthologous gene family
ORTHO03P075425
(2 genes in 2 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
granzyme B (granzyme 2, cytotoxic T-lymphocyte- associated serine esterase 1)

Identifiers

Type Value
pidENSP00000216341
HGNC4709
UniprotP10144

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006508
IEA
Genome Projectproteolysis
GO:0006915
TAS, IEA
Genome Projectapoptotic process
GO:0007219
TAS
Genome ProjectNotch signaling pathway
GO:0008626
IBA
Genome Projectgranzyme-mediated apoptotic signaling pathway
GO:0012501
TAS
Genome Projectprogrammed cell death
GO:0016485
IBA
Genome Projectprotein processing
GO:0019835
IEA
Genome Projectcytolysis
GO:0042267
IMP
Genome Projectnatural killer cell mediated cytotoxicity
GO:0097193
TAS
Genome Projectintrinsic apoptotic signaling pathway
GO:1900740
TAS
Genome Projectpositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004252
IDA
TAS, IEA
Genome Projectserine-type endopeptidase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008233
IEA
Genome Projectpeptidase activity
GO:0008236
TAS, IEA
Genome Projectserine-type peptidase activity
GO:0016787
IEA
Genome Projecthydrolase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001772
TAS
Genome Projectimmunological synapse
GO:0005634
TAS
Genome Projectnucleus
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005829
TAS
Genome Projectcytosol
GO:0016020
IDA
Genome Projectmembrane
GO:0043231
IDA
Genome Projectintracellular membrane-bounded organelle

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001254Serine proteases, trypsin domain
IPR001314Peptidase S1A, chymotrypsin-type
IPR009003Peptidase S1, PA clan
IPR018114Peptidase S1, trypsin family, active site

No MapMan annotations defined for this gene.