Gene: ENSG00000100387 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000100387
Transcript Identifier
ENST00000216225
Gene Type
Coding gene
Location
22 : 40951399-40972488 : positive

Family Information

Homologous gene family
HOM03P000553
(90 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P000775
(44 genes in 38 species)
specific family

Descriptions

gene_descr
ring-box 1, E3 ubiquitin protein ligase

Identifiers

Type Value
pidENSP00000216225
HGNC9928
UniprotP62877

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006281
TAS, IEA
Genome ProjectDNA repair
GO:0006513
IDA
Genome Projectprotein monoubiquitination
GO:0006974
IEA
Genome Projectcellular response to DNA damage stimulus
GO:0007219
TAS
Genome ProjectNotch signaling pathway
GO:0016032
TAS, IEA
Genome Projectviral process
GO:0016567
IDA
IEA
Genome Projectprotein ubiquitination
GO:0019985
TAS
Genome Projecttranslesion synthesis
GO:0030163
IEA
Genome Projectprotein catabolic process
GO:0031146
IDA
ISS
Genome ProjectSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0042769
TAS
Genome ProjectDNA damage response, detection of DNA damage
GO:0042787
IBA
Genome Projectprotein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161
IDA
Genome Projectproteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045116
IDA
Genome Projectprotein neddylation
GO:0061418
TAS
Genome Projectregulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456
TAS
Genome Projectcellular response to hypoxia
GO:0090090
TAS
Genome Projectnegative regulation of canonical Wnt signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005515
IPI
Genome Projectprotein binding
GO:0008270
IEA
Genome Projectzinc ion binding
GO:0016874
IEA
Genome Projectligase activity
GO:0019788
IDA
Genome ProjectNEDD8 transferase activity
GO:0031625
IDA
Genome Projectubiquitin protein ligase binding
GO:0032403
IEA
Genome Projectprotein complex binding
GO:0034450
IDA
Genome Projectubiquitin-ubiquitin ligase activity
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0061630
IDA
TAS
Genome Projectubiquitin protein ligase activity
GO:0097602
IDA
Genome Projectcullin family protein binding
GO:0004842
IDA
Genome Projectubiquitin-protein transferase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IEA
Genome Projectnucleus
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005829
ISS
TAS, IEA
Genome Projectcytosol
GO:0019005
IDA
ISS
Genome ProjectSCF ubiquitin ligase complex
GO:0030891
IEA
Genome ProjectVCB complex
GO:0031461
IDA
Genome Projectcullin-RING ubiquitin ligase complex
GO:0031462
IDA
Genome ProjectCul2-RING ubiquitin ligase complex
GO:0031463
IDA
Genome ProjectCul3-RING ubiquitin ligase complex
GO:0031464
IDA
Genome ProjectCul4A-RING E3 ubiquitin ligase complex
GO:0031465
IDA
Genome ProjectCul4B-RING E3 ubiquitin ligase complex
GO:0031466
IDA
Genome ProjectCul5-RING ubiquitin ligase complex
GO:0031467
IDA
Genome ProjectCul7-RING ubiquitin ligase complex
GO:0043224
IBA
Genome Projectnuclear SCF ubiquitin ligase complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001841Zinc finger, RING-type
IPR013083Zinc finger, RING/FYVE/PHD-type
IPR024766Zinc finger, RING-H2-type

No MapMan annotations defined for this gene.