Gene: ENSG00000100311 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000100311
Transcript Identifier
ENST00000331163
Gene Type
Coding gene
Location
22 : 39225723-39243963 : negative

Family Information

Homologous gene family
HOM03P013721
(6 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P075595
(2 genes in 2 species)
specific family

Descriptions

gene_descr
platelet-derived growth factor beta polypeptide

Identifiers

Type Value
pidENSP00000330382
HGNC8800
UniprotP01127

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001666
IEA
Genome Projectresponse to hypoxia
GO:0001892
ISS
Genome Projectembryonic placenta development
GO:0001938
IDA
Genome Projectpositive regulation of endothelial cell proliferation
GO:0002548
IDA
Genome Projectmonocyte chemotaxis
GO:0002576
TAS
Genome Projectplatelet degranulation
GO:0003104
ISS
Genome Projectpositive regulation of glomerular filtration
GO:0006260
IEA
Genome ProjectDNA replication
GO:0006468
IDA
Genome Projectprotein phosphorylation
GO:0007173
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007179
ISS
Genome Projecttransforming growth factor beta receptor signaling pathway
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007507
ISS
Genome Projectheart development
GO:0007596
TAS
Genome Projectblood coagulation
GO:0008284
IDA
Genome Projectpositive regulation of cell proliferation
GO:0008543
TAS
Genome Projectfibroblast growth factor receptor signaling pathway
GO:0009611
IDA
NAS
Genome Projectresponse to wounding
GO:0010033
IEA
Genome Projectresponse to organic substance
GO:0010512
IDA
Genome Projectnegative regulation of phosphatidylinositol biosynthetic process
GO:0010544
IDA
Genome Projectnegative regulation of platelet activation
GO:0010628
IDA
Genome Projectpositive regulation of gene expression
GO:0014068
IDA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0014911
IDA
IEA
Genome Projectpositive regulation of smooth muscle cell migration
GO:0016049
IEA
Genome Projectcell growth
GO:0018105
IDA
Genome Projectpeptidyl-serine phosphorylation
GO:0018108
IDA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0030168
TAS
Genome Projectplatelet activation
GO:0030198
TAS
Genome Projectextracellular matrix organization
GO:0030335
IDA
Genome Projectpositive regulation of cell migration
GO:0031954
IDA
Genome Projectpositive regulation of protein autophosphorylation
GO:0032091
IDA
Genome Projectnegative regulation of protein binding
GO:0032147
IDA
Genome Projectactivation of protein kinase activity
GO:0032148
IDA
Genome Projectactivation of protein kinase B activity
GO:0032355
IEA
Genome Projectresponse to estradiol
GO:0032868
IEA
Genome Projectresponse to insulin
GO:0035793
IDA
Genome Projectpositive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0038001
ISS
Genome Projectparacrine signaling
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0042060
IEA
Genome Projectwound healing
GO:0042127
IEA
Genome Projectregulation of cell proliferation
GO:0042493
IEA
Genome Projectresponse to drug
GO:0043406
IDA
Genome Projectpositive regulation of MAP kinase activity
GO:0043410
IMP
Genome Projectpositive regulation of MAPK cascade
GO:0043536
IDA
Genome Projectpositive regulation of blood vessel endothelial cell migration
GO:0043552
IDA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase activity
GO:0043627
IEA
Genome Projectresponse to estrogen
GO:0045087
TAS
Genome Projectinnate immune response
GO:0045737
IDA
Genome Projectpositive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045740
IDA
Genome Projectpositive regulation of DNA replication
GO:0045840
IDA
Genome Projectpositive regulation of mitotic nuclear division
GO:0045892
IDA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IDA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0048008
IDA
IEA
Genome Projectplatelet-derived growth factor receptor signaling pathway
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048015
TAS
Genome Projectphosphatidylinositol-mediated signaling
GO:0048146
IDA
Genome Projectpositive regulation of fibroblast proliferation
GO:0048661
IDA
IEA
Genome Projectpositive regulation of smooth muscle cell proliferation
GO:0050731
IDA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050918
IDA
Genome Projectpositive chemotaxis
GO:0050921
IDA
Genome Projectpositive regulation of chemotaxis
GO:0051781
IEA
Genome Projectpositive regulation of cell division
GO:0060326
IDA
Genome Projectcell chemotaxis
GO:0061098
IDA
Genome Projectpositive regulation of protein tyrosine kinase activity
GO:0070374
IDA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0070528
IMP
Genome Projectprotein kinase C signaling
GO:0071363
IDA
Genome Projectcellular response to growth factor stimulus
GO:0071506
ISS
Genome Projectcellular response to mycophenolic acid
GO:0072126
IDA
Genome Projectpositive regulation of glomerular mesangial cell proliferation
GO:0072255
ISS
Genome Projectmetanephric glomerular mesangial cell development
GO:0072593
IMP
Genome Projectreactive oxygen species metabolic process
GO:0090280
IDA
Genome Projectpositive regulation of calcium ion import
GO:1900127
IDA
Genome Projectpositive regulation of hyaluronan biosynthetic process
GO:2000379
IDA
Genome Projectpositive regulation of reactive oxygen species metabolic process
GO:2000573
IDA
Genome Projectpositive regulation of DNA biosynthetic process
GO:2000591
IDA
Genome Projectpositive regulation of metanephric mesenchymal cell migration
GO:0030097
IMP
Genome Projecthemopoiesis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005161
IDA, IPI
NAS
Genome Projectplatelet-derived growth factor receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005518
IDA
Genome Projectcollagen binding
GO:0008083
IDA
IEA
Genome Projectgrowth factor activity
GO:0016176
IDA
Genome Projectsuperoxide-generating NADPH oxidase activator activity
GO:0042056
IDA
Genome Projectchemoattractant activity
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042803
IDA
Genome Projectprotein homodimerization activity
GO:0046982
IPI
Genome Projectprotein heterodimerization activity
GO:0048407
IPI
Genome Projectplatelet-derived growth factor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000139
TAS
Genome ProjectGolgi membrane
GO:0005576
TAS, NAS, IEA
Genome Projectextracellular region
GO:0005615
IBA
Genome Projectextracellular space
GO:0005737
ISS
Genome Projectcytoplasm
GO:0005788
TAS
Genome Projectendoplasmic reticulum lumen
GO:0009986
IDA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016323
ISS
Genome Projectbasolateral plasma membrane
GO:0031093
TAS
Genome Projectplatelet alpha granule lumen

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000072PDGF/VEGF domain
IPR006782Platelet-derived growth factor, N-terminal
IPR023581Platelet-derived growth factor, conserved site
IPR029034Cystine-knot cytokine

No MapMan annotations defined for this gene.