Gene: ENSG00000100030 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000100030
Transcript Identifier
ENST00000398822
Gene Type
Coding gene
Location
22 : 21769204-21867440 : negative

Family Information

Homologous gene family
HOM03P000009
(1563 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P000210
(62 genes in 33 species)
specific family

Descriptions

gene_descr
mitogen-activated protein kinase 1

Identifiers

Type Value
pidENSP00000381803
HGNC6871
UniprotP28482
UniprotQ1HBJ4

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000165
TAS, IEA
Genome ProjectMAPK cascade
GO:0000186
TAS
Genome Projectactivation of MAPKK activity
GO:0000187
TAS
Genome Projectactivation of MAPK activity
GO:0000189
IEA
Genome ProjectMAPK import into nucleus
GO:0002224
TAS
Genome Projecttoll-like receptor signaling pathway
GO:0002755
TAS
Genome ProjectMyD88-dependent toll-like receptor signaling pathway
GO:0002756
TAS
Genome ProjectMyD88-independent toll-like receptor signaling pathway
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006468
IDA
IEA
Genome Projectprotein phosphorylation
GO:0006915
TAS, IEA
Genome Projectapoptotic process
GO:0006935
TAS
Genome Projectchemotaxis
GO:0006950
TAS
Genome Projectresponse to stress
GO:0006974
IEA
Genome Projectcellular response to DNA damage stimulus
GO:0007049
IEA
Genome Projectcell cycle
GO:0007165
TAS, IEA
Genome Projectsignal transduction
GO:0007173
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007264
TAS
Genome Projectsmall GTPase mediated signal transduction
GO:0007265
TAS
Genome ProjectRas protein signal transduction
GO:0007268
TAS
Genome Projectsynaptic transmission
GO:0007411
TAS
Genome Projectaxon guidance
GO:0007596
TAS
Genome Projectblood coagulation
GO:0008284
IEA
Genome Projectpositive regulation of cell proliferation
GO:0008286
TAS
Genome Projectinsulin receptor signaling pathway
GO:0008543
TAS
Genome Projectfibroblast growth factor receptor signaling pathway
GO:0009636
IEA
Genome Projectresponse to toxic substance
GO:0009887
IEA
Genome Projectorgan morphogenesis
GO:0010800
IDA
Genome Projectpositive regulation of peptidyl-threonine phosphorylation
GO:0016032
IEA
Genome Projectviral process
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018105
IDA
IEA
Genome Projectpeptidyl-serine phosphorylation
GO:0018107
ISS
IEA
Genome Projectpeptidyl-threonine phosphorylation
GO:0019233
IEA
Genome Projectsensory perception of pain
GO:0019858
IEA
Genome Projectcytosine metabolic process
GO:0030168
TAS
Genome Projectplatelet activation
GO:0030335
IEA
Genome Projectpositive regulation of cell migration
GO:0031647
ISS
Genome Projectregulation of protein stability
GO:0031663
IEA
Genome Projectlipopolysaccharide-mediated signaling pathway
GO:0032496
IEA
Genome Projectresponse to lipopolysaccharide
GO:0032872
TAS
Genome Projectregulation of stress-activated MAPK cascade
GO:0033598
IEA
Genome Projectmammary gland epithelial cell proliferation
GO:0034134
TAS
Genome Projecttoll-like receptor 2 signaling pathway
GO:0034138
TAS
Genome Projecttoll-like receptor 3 signaling pathway
GO:0034142
TAS
Genome Projecttoll-like receptor 4 signaling pathway
GO:0034146
TAS
Genome Projecttoll-like receptor 5 signaling pathway
GO:0034162
TAS
Genome Projecttoll-like receptor 9 signaling pathway
GO:0034166
TAS
Genome Projecttoll-like receptor 10 signaling pathway
GO:0034605
TAS
Genome Projectcellular response to heat
GO:0035556
IEA
Genome Projectintracellular signal transduction
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0038096
TAS
Genome ProjectFc-gamma receptor signaling pathway involved in phagocytosis
GO:0038123
TAS
Genome Projecttoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124
TAS
Genome Projecttoll-like receptor TLR6:TLR2 signaling pathway
GO:0038127
IDA
Genome ProjectERBB signaling pathway
GO:0043330
IEA
Genome Projectresponse to exogenous dsRNA
GO:0043627
IEA
Genome Projectresponse to estrogen
GO:0045087
TAS
Genome Projectinnate immune response
GO:0045596
IEA
Genome Projectnegative regulation of cell differentiation
GO:0045727
IEA
Genome Projectpositive regulation of translation
GO:0045893
IEA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0048010
TAS
Genome Projectvascular endothelial growth factor receptor signaling pathway
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0050852
IEA
Genome ProjectT cell receptor signaling pathway
GO:0050853
IEA
Genome ProjectB cell receptor signaling pathway
GO:0051090
TAS
Genome Projectregulation of sequence-specific DNA binding transcription factor activity
GO:0051403
TAS
Genome Projectstress-activated MAPK cascade
GO:0051493
TAS
Genome Projectregulation of cytoskeleton organization
GO:0060291
IEA
Genome Projectlong-term synaptic potentiation
GO:0060397
TAS
Genome ProjectJAK-STAT cascade involved in growth hormone signaling pathway
GO:0060425
IEA
Genome Projectlung morphogenesis
GO:0060440
IEA
Genome Projecttrachea formation
GO:0060716
IEA
Genome Projectlabyrinthine layer blood vessel development
GO:0070371
IDA
TAS
Genome ProjectERK1 and ERK2 cascade
GO:0070849
IDA
Genome Projectresponse to epidermal growth factor
GO:0071310
IEA
Genome Projectcellular response to organic substance
GO:0072584
TAS
Genome Projectcaveolin-mediated endocytosis
GO:0090170
TAS
Genome Projectregulation of Golgi inheritance
GO:0097011
IEA
Genome Projectcellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:1900034
TAS
Genome Projectregulation of cellular response to heat
GO:2000641
TAS
Genome Projectregulation of early endosome to late endosome transport

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0001784
IEA
Genome Projectphosphotyrosine binding
GO:0003677
IEA
Genome ProjectDNA binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004674
IDA
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004707
TAS, IEA
Genome ProjectMAP kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0008134
IEA
Genome Projecttranscription factor binding
GO:0008353
ISS
IEA
Genome ProjectRNA polymerase II carboxy-terminal domain kinase activity
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019901
IEA
Genome Projectprotein kinase binding
GO:0019902
IPI
Genome Projectphosphatase binding
GO:0031435
IEA
Genome Projectmitogen-activated protein kinase kinase kinase binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
TAS, IEA
Genome Projectnucleus
GO:0005654
IDA
TAS, IEA
Genome Projectnucleoplasm
GO:0005737
IDA
ISS
IEA
Genome Projectcytoplasm
GO:0005739
TAS, IEA
Genome Projectmitochondrion
GO:0005769
TAS
Genome Projectearly endosome
GO:0005770
TAS
Genome Projectlate endosome
GO:0005794
TAS
Genome ProjectGolgi apparatus
GO:0005815
IEA
Genome Projectmicrotubule organizing center
GO:0005819
IEA
Genome Projectspindle
GO:0005829
TAS, IEA
Genome Projectcytosol
GO:0005856
TAS, IEA
Genome Projectcytoskeleton
GO:0005901
TAS
Genome Projectcaveola
GO:0005925
TAS
Genome Projectfocal adhesion
GO:0015630
IDA
Genome Projectmicrotubule cytoskeleton
GO:0030424
IEA
Genome Projectaxon
GO:0031143
IEA
Genome Projectpseudopodium
GO:0032839
IEA
Genome Projectdendrite cytoplasm
GO:0043204
IEA
Genome Projectperikaryon
GO:0043234
IEA
Genome Projectprotein complex
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0072686
ISS
Genome Projectmitotic spindle

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR002290Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003527Mitogen-activated protein (MAP) kinase, conserved site
IPR008271Serine/threonine-protein kinase, active site
IPR008349Mitogen-activated protein (MAP) kinase, ERK1/2
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site

No MapMan annotations defined for this gene.