Gene: ENSG00000099250 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000099250
Transcript Identifier
ENST00000374867
Gene Type
Coding gene
Location
10 : 33180076-33334382 : negative

Family Information

Homologous gene family
HOM03P000563
(89 genes in 8 species)
specific family
Orthologous gene family
ORTHO03P023842
(4 genes in 2 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
neuropilin 1

Identifiers

Type Value
pidENSP00000364001
HGNC8004
UniprotO14786

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001525
IMP
ISS
IEA
Genome Projectangiogenesis
GO:0001569
ISS
IEA
Genome Projectpatterning of blood vessels
GO:0001764
ISS
IEA
Genome Projectneuron migration
GO:0001938
TAS
Genome Projectpositive regulation of endothelial cell proliferation
GO:0002040
ISS
IEA
Genome Projectsprouting angiogenesis
GO:0002042
ISS
IEA
Genome Projectcell migration involved in sprouting angiogenesis
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007267
TAS
Genome Projectcell-cell signaling
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007399
IEA
Genome Projectnervous system development
GO:0007411
TAS, NAS, IEA
Genome Projectaxon guidance
GO:0007413
IEA
Genome Projectaxonal fasciculation
GO:0007507
IEA
Genome Projectheart development
GO:0008045
IEA
Genome Projectmotor neuron axon guidance
GO:0009887
TAS, IEA
Genome Projectorgan morphogenesis
GO:0010595
TAS
Genome Projectpositive regulation of endothelial cell migration
GO:0014911
TAS
Genome Projectpositive regulation of smooth muscle cell migration
GO:0016358
IEA
Genome Projectdendrite development
GO:0016477
IEA
Genome Projectcell migration
GO:0021612
IEA
Genome Projectfacial nerve structural organization
GO:0021636
IEA
Genome Projecttrigeminal nerve morphogenesis
GO:0021637
IEA
Genome Projecttrigeminal nerve structural organization
GO:0021649
IEA
Genome Projectvestibulocochlear nerve structural organization
GO:0021675
ISS
IEA
Genome Projectnerve development
GO:0021785
IEA
Genome Projectbranchiomotor neuron axon guidance
GO:0021828
IEA
Genome Projectgonadotrophin-releasing hormone neuronal migration to the hypothalamus
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030517
IEA
Genome Projectnegative regulation of axon extension
GO:0031290
ISS
IEA
Genome Projectretinal ganglion cell axon guidance
GO:0035729
IMP
Genome Projectcellular response to hepatocyte growth factor stimulus
GO:0035767
IMP
IEA
Genome Projectendothelial cell chemotaxis
GO:0035924
ISS
IEA
Genome Projectcellular response to vascular endothelial growth factor stimulus
GO:0036486
IEA
Genome Projectventral trunk neural crest cell migration
GO:0038084
IEA
Genome Projectvascular endothelial growth factor signaling pathway
GO:0038190
ISS
IEA
Genome ProjectVEGF-activated neuropilin signaling pathway
GO:0043049
IEA
Genome Projectotic placode formation
GO:0043524
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0048008
IMP
Genome Projectplatelet-derived growth factor receptor signaling pathway
GO:0048010
IMP
TAS, IEA
Genome Projectvascular endothelial growth factor receptor signaling pathway
GO:0048012
IMP
Genome Projecthepatocyte growth factor receptor signaling pathway
GO:0048485
IEA
Genome Projectsympathetic nervous system development
GO:0048666
IEA
Genome Projectneuron development
GO:0048841
IEA
Genome Projectregulation of axon extension involved in axon guidance
GO:0048842
ISS
IEA
Genome Projectpositive regulation of axon extension involved in axon guidance
GO:0048843
IEA
Genome Projectnegative regulation of axon extension involved in axon guidance
GO:0048844
ISS
IEA
Genome Projectartery morphogenesis
GO:0048846
ISS
IEA
Genome Projectaxon extension involved in axon guidance
GO:0050731
IMP
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050918
ISS
IEA
Genome Projectpositive chemotaxis
GO:0060301
TAS
Genome Projectpositive regulation of cytokine activity
GO:0060385
ISS
IEA
Genome Projectaxonogenesis involved in innervation
GO:0060627
TAS
Genome Projectregulation of vesicle-mediated transport
GO:0060666
IEA
Genome Projectdichotomous subdivision of terminal units involved in salivary gland branching
GO:0060978
ISS
IEA
Genome Projectangiogenesis involved in coronary vascular morphogenesis
GO:0060982
IEA
Genome Projectcoronary artery morphogenesis
GO:0061299
ISS
IEA
Genome Projectretina vasculature morphogenesis in camera-type eye
GO:0061441
IEA
Genome Projectrenal artery morphogenesis
GO:0061549
ISS
IEA
Genome Projectsympathetic ganglion development
GO:0061551
IEA
Genome Projecttrigeminal ganglion development
GO:0061552
IEA
Genome Projectganglion morphogenesis
GO:0070374
ISS
IEA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0071526
NAS, IEA
Genome Projectsemaphorin-plexin signaling pathway
GO:0071679
ISS
IEA
Genome Projectcommissural neuron axon guidance
GO:0090259
ISS
IEA
Genome Projectregulation of retinal ganglion cell axon guidance
GO:0097102
ISS
Genome Projectendothelial tip cell fate specification
GO:0097374
IEA
Genome Projectsensory neuron axon guidance
GO:0097490
ISS
IEA
Genome Projectsympathetic neuron projection extension
GO:0097491
ISS
IEA
Genome Projectsympathetic neuron projection guidance
GO:1901166
ISS
IEA
Genome Projectneural crest cell migration involved in autonomic nervous system development
GO:1901998
IEA
Genome Projecttoxin transport
GO:1902285
ISS
IEA
Genome Projectsemaphorin-plexin signaling pathway involved in neuron projection guidance
GO:1902287
IEA
Genome Projectsemaphorin-plexin signaling pathway involved in axon guidance
GO:1902336
ISS
IEA
Genome Projectpositive regulation of retinal ganglion cell axon guidance
GO:1902378
IEA
Genome ProjectVEGF-activated neuropilin signaling pathway involved in axon guidance
GO:1902946
ISS
IEA
Genome Projectprotein localization to early endosome
GO:1903375
IEA
Genome Projectfacioacoustic ganglion development
GO:2001237
IEA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005021
ISS
TAS, NAS, IEA
Genome Projectvascular endothelial growth factor-activated receptor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008201
IEA
Genome Projectheparin binding
GO:0015026
TAS
Genome Projectcoreceptor activity
GO:0017154
NAS, IEA
Genome Projectsemaphorin receptor activity
GO:0019838
IPI
TAS, IEA
Genome Projectgrowth factor binding
GO:0019955
NAS
Genome Projectcytokine binding
GO:0038085
IPI
Genome Projectvascular endothelial growth factor binding
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002116
NAS
Genome Projectsemaphorin receptor complex
GO:0005576
IEA
Genome Projectextracellular region
GO:0005615
IDA
Genome Projectextracellular space
GO:0005769
ISS
IEA
Genome Projectearly endosome
GO:0005829
IDA
Genome Projectcytosol
GO:0005883
IEA
Genome Projectneurofilament
GO:0005886
IDA
TAS, IEA
Genome Projectplasma membrane
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0030424
ISS
IEA
Genome Projectaxon
GO:0031410
TAS
Genome Projectcytoplasmic vesicle
GO:0043235
TAS
Genome Projectreceptor complex
GO:0097443
ISS
IEA
Genome Projectsorting endosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000421Coagulation factor 5/8 C-terminal domain
IPR000859CUB domain
IPR000998MAM domain
IPR008979Galactose-binding domain-like
IPR013320Concanavalin A-like lectin/glucanase domain
IPR014648Neuropilin
IPR022579Neuropilin-1, C-terminal
IPR027146Neuropilin-1

No MapMan annotations defined for this gene.