Gene: ENSG00000096968 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000096968
Transcript Identifier
ENST00000381652
Gene Type
Coding gene
Location
9 : 5021988-5126791 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P011898
(7 genes in 4 species)
specific family

Descriptions

gene_descr
Janus kinase 2

Identifiers

Type Value
pidENSP00000371067
HGNC6192
UniprotO60674

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000186
IEA
Genome Projectactivation of MAPKK activity
GO:0002250
IEA
Genome Projectadaptive immune response
GO:0002376
IEA
Genome Projectimmune system process
GO:0006325
TAS
Genome Projectchromatin organization
GO:0006468
TAS, IEA
Genome Projectprotein phosphorylation
GO:0006915
ISS
Genome Projectapoptotic process
GO:0006919
ISS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006928
TAS
Genome Projectmovement of cell or subcellular component
GO:0006979
IEA
Genome Projectresponse to oxidative stress
GO:0007165
ISS
Genome Projectsignal transduction
GO:0007167
ISS
IEA
Genome Projectenzyme linked receptor protein signaling pathway
GO:0007186
IEA
Genome ProjectG-protein coupled receptor signaling pathway
GO:0007204
IEA
Genome Projectpositive regulation of cytosolic calcium ion concentration
GO:0007259
TAS, IEA
Genome ProjectJAK-STAT cascade
GO:0007260
ISS, IBA
IEA
Genome Projecttyrosine phosphorylation of STAT protein
GO:0007262
ISS
IEA
Genome ProjectSTAT protein import into nucleus
GO:0007498
TAS
Genome Projectmesoderm development
GO:0007596
TAS
Genome Projectblood coagulation
GO:0008284
IEA
Genome Projectpositive regulation of cell proliferation
GO:0008285
ISS
IEA
Genome Projectnegative regulation of cell proliferation
GO:0008631
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009755
IEA
Genome Projecthormone-mediated signaling pathway
GO:0010667
IEA
Genome Projectnegative regulation of cardiac muscle cell apoptotic process
GO:0010811
IDA
Genome Projectpositive regulation of cell-substrate adhesion
GO:0014068
ISS
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0016310
IEA
Genome Projectphosphorylation
GO:0016477
IBA
Genome Projectcell migration
GO:0016568
IEA
Genome Projectchromatin modification
GO:0018108
ISS
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0019221
IDA
ISS
TAS
Genome Projectcytokine-mediated signaling pathway
GO:0022408
IEA
Genome Projectnegative regulation of cell-cell adhesion
GO:0030041
NAS
Genome Projectactin filament polymerization
GO:0030099
IEA
Genome Projectmyeloid cell differentiation
GO:0030154
ISS
IEA
Genome Projectcell differentiation
GO:0030218
ISS, IBA
Genome Projecterythrocyte differentiation
GO:0030335
IEA
Genome Projectpositive regulation of cell migration
GO:0031103
IEA
Genome Projectaxon regeneration
GO:0031959
IEA
Genome Projectmineralocorticoid receptor signaling pathway
GO:0032024
IEA
Genome Projectpositive regulation of insulin secretion
GO:0032496
ISS
Genome Projectresponse to lipopolysaccharide
GO:0032516
IEA
Genome Projectpositive regulation of phosphoprotein phosphatase activity
GO:0032731
IEA
Genome Projectpositive regulation of interleukin-1 beta production
GO:0032760
ISS
Genome Projectpositive regulation of tumor necrosis factor production
GO:0033160
IEA
Genome Projectpositive regulation of protein import into nucleus, translocation
GO:0033194
IEA
Genome Projectresponse to hydroperoxide
GO:0033209
IDA
Genome Projecttumor necrosis factor-mediated signaling pathway
GO:0034050
IEA
Genome Projecthost programmed cell death induced by symbiont
GO:0034612
IDA
Genome Projectresponse to tumor necrosis factor
GO:0035409
IDA
Genome Projecthistone H3-Y41 phosphorylation
GO:0035556
ISS
TAS, IEA
Genome Projectintracellular signal transduction
GO:0035722
IDA
Genome Projectinterleukin-12-mediated signaling pathway
GO:0038083
IBA
Genome Projectpeptidyl-tyrosine autophosphorylation
GO:0042127
IBA
Genome Projectregulation of cell proliferation
GO:0042503
IEA
Genome Projecttyrosine phosphorylation of Stat3 protein
GO:0042506
IEA
Genome Projecttyrosine phosphorylation of Stat5 protein
GO:0042508
IEA
Genome Projecttyrosine phosphorylation of Stat1 protein
GO:0042517
ISS
Genome Projectpositive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523
ISS
Genome Projectpositive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042977
ISS
Genome Projectactivation of JAK2 kinase activity
GO:0042981
IBA
Genome Projectregulation of apoptotic process
GO:0043065
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043066
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043388
IEA
Genome Projectpositive regulation of DNA binding
GO:0043392
ISS
IEA
Genome Projectnegative regulation of DNA binding
GO:0043524
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0045087
IBA
IEA
Genome Projectinnate immune response
GO:0045429
IEA
Genome Projectpositive regulation of nitric oxide biosynthetic process
GO:0045597
IEA
Genome Projectpositive regulation of cell differentiation
GO:0045822
IEA
Genome Projectnegative regulation of heart contraction
GO:0045944
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046677
IDA
Genome Projectresponse to antibiotic
GO:0046777
ISS
Genome Projectprotein autophosphorylation
GO:0048008
IEA
Genome Projectplatelet-derived growth factor receptor signaling pathway
GO:0050727
IDA
Genome Projectregulation of inflammatory response
GO:0050729
IEA
Genome Projectpositive regulation of inflammatory response
GO:0050731
ISS
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050867
IEA
Genome Projectpositive regulation of cell activation
GO:0051091
IEA
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0051770
ISS
IEA
Genome Projectpositive regulation of nitric-oxide synthase biosynthetic process
GO:0060333
TAS, IEA
Genome Projectinterferon-gamma-mediated signaling pathway
GO:0060334
TAS
Genome Projectregulation of interferon-gamma-mediated signaling pathway
GO:0060396
IDA
Genome Projectgrowth hormone receptor signaling pathway
GO:0060397
ISS
TAS
Genome ProjectJAK-STAT cascade involved in growth hormone signaling pathway
GO:0060399
ISS
Genome Projectpositive regulation of growth hormone receptor signaling pathway
GO:0061180
ISS
IEA
Genome Projectmammary gland epithelium development
GO:0070671
IDA
Genome Projectresponse to interleukin-12
GO:0071222
IEA
Genome Projectcellular response to lipopolysaccharide
GO:0071549
IEA
Genome Projectcellular response to dexamethasone stimulus
GO:0097191
ISS
IEA
Genome Projectextrinsic apoptotic signaling pathway
GO:0097296
ISS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:2001235
IEA
Genome Projectpositive regulation of apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
NAS, IEA
Genome Projectprotein kinase activity
GO:0004713
EXP, IDA
ISS
TAS, IEA
Genome Projectprotein tyrosine kinase activity
GO:0004715
IBA
IEA
Genome Projectnon-membrane spanning protein tyrosine kinase activity
GO:0005102
IPI
Genome Projectreceptor binding
GO:0005131
ISS, IBA
IEA
Genome Projectgrowth hormone receptor binding
GO:0005143
ISS
IEA
Genome Projectinterleukin-12 receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0008022
IEA
Genome Projectprotein C-terminus binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019901
IDA
Genome Projectprotein kinase binding
GO:0020037
IDA
Genome Projectheme binding
GO:0031702
IEA
Genome Projecttype 1 angiotensin receptor binding
GO:0033130
IEA
Genome Projectacetylcholine receptor binding
GO:0035401
IDA
Genome Projecthistone kinase activity (H3-Y41 specific)
GO:0042169
IPI
Genome ProjectSH2 domain binding
GO:0042393
IDA
IEA
Genome Projecthistone binding
GO:0043548
IEA
Genome Projectphosphatidylinositol 3-kinase binding
GO:0043560
IEA
Genome Projectinsulin receptor substrate binding
GO:0051428
IEA
Genome Projectpeptide hormone receptor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005829
TAS, IEA
Genome Projectcytosol
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005901
ISS
IEA
Genome Projectcaveola
GO:0012505
IEA
Genome Projectendomembrane system
GO:0016020
IEA
Genome Projectmembrane
GO:0016363
IEA
Genome Projectnuclear matrix
GO:0031234
IBA
Genome Projectextrinsic component of cytoplasmic side of plasma membrane
GO:0031904
TAS
Genome Projectendosome lumen
GO:0045121
ISS
IEA
Genome Projectmembrane raft

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000299FERM domain
IPR000719Protein kinase domain
IPR000980SH2 domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR016251Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR017441Protein kinase, ATP binding site
IPR019748FERM central domain
IPR019749Band 4.1 domain
IPR020635Tyrosine-protein kinase, catalytic domain
IPR020693Tyrosine-protein kinase, non-receptor Jak2

No MapMan annotations defined for this gene.