Gene: ENSG00000092969 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000092969
Transcript Identifier
ENST00000366929
Gene Type
Coding gene
Location
1 : 218346702-218441362 : positive

Family Information

Homologous gene family
HOM03P019048
(4 genes in 2 species)
specific family
Orthologous gene family
ORTHO03P074175
(2 genes in 2 species)
specific family

Descriptions

gene_descr
transforming growth factor, beta 2

Identifiers

Type Value
pidENSP00000355896
HGNC11768
UniprotP61812

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000902
IDA
Genome Projectcell morphogenesis
GO:0001501
IEA
Genome Projectskeletal system development
GO:0001502
IEA
Genome Projectcartilage condensation
GO:0001525
TAS
Genome Projectangiogenesis
GO:0001568
IEA
Genome Projectblood vessel development
GO:0001654
IDA
Genome Projecteye development
GO:0001666
IMP
Genome Projectresponse to hypoxia
GO:0001837
IDA
TAS
Genome Projectepithelial to mesenchymal transition
GO:0001942
IDA
ISS
Genome Projecthair follicle development
GO:0001974
IEA
Genome Projectblood vessel remodeling
GO:0002576
TAS
Genome Projectplatelet degranulation
GO:0003007
IDA
Genome Projectheart morphogenesis
GO:0003179
IEA
Genome Projectheart valve morphogenesis
GO:0006468
IDA
Genome Projectprotein phosphorylation
GO:0007050
IDA
Genome Projectcell cycle arrest
GO:0007179
IDA
Genome Projecttransforming growth factor beta receptor signaling pathway
GO:0007184
IDA
Genome ProjectSMAD protein import into nucleus
GO:0007267
TAS
Genome Projectcell-cell signaling
GO:0007411
IEA
Genome Projectaxon guidance
GO:0007435
IEP
Genome Projectsalivary gland morphogenesis
GO:0007507
IDA
Genome Projectheart development
GO:0007596
TAS
Genome Projectblood coagulation
GO:0008219
IDA
Genome Projectcell death
GO:0008283
TAS
Genome Projectcell proliferation
GO:0008284
IDA
Genome Projectpositive regulation of cell proliferation
GO:0008285
IDA
Genome Projectnegative regulation of cell proliferation
GO:0008347
IDA
Genome Projectglial cell migration
GO:0009611
IEP
Genome Projectresponse to wounding
GO:0009790
TAS
Genome Projectembryo development
GO:0010002
IDA
Genome Projectcardioblast differentiation
GO:0010628
IEA
Genome Projectpositive regulation of gene expression
GO:0010634
IDA
Genome Projectpositive regulation of epithelial cell migration
GO:0010693
IDA
Genome Projectnegative regulation of alkaline phosphatase activity
GO:0010718
IDA
Genome Projectpositive regulation of epithelial to mesenchymal transition
GO:0010862
IBA
Genome Projectpositive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010936
IDA
Genome Projectnegative regulation of macrophage cytokine production
GO:0014068
IDA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0016049
IEA
Genome Projectcell growth
GO:0016477
IDA
Genome Projectcell migration
GO:0023014
IDA
Genome Projectsignal transduction by protein phosphorylation
GO:0030097
ISS
IEA
Genome Projecthemopoiesis
GO:0030168
TAS
Genome Projectplatelet activation
GO:0030198
TAS, IEA
Genome Projectextracellular matrix organization
GO:0030199
IDA
Genome Projectcollagen fibril organization
GO:0030307
IDA
Genome Projectpositive regulation of cell growth
GO:0030308
IDA
Genome Projectnegative regulation of cell growth
GO:0030593
ISS
TAS
Genome Projectneutrophil chemotaxis
GO:0031069
ISS
IEA
Genome Projecthair follicle morphogenesis
GO:0032147
IDA
Genome Projectactivation of protein kinase activity
GO:0032570
IDA
Genome Projectresponse to progesterone
GO:0032874
IDA
Genome Projectpositive regulation of stress-activated MAPK cascade
GO:0032909
IMP
Genome Projectregulation of transforming growth factor beta2 production
GO:0033630
IDA
Genome Projectpositive regulation of cell adhesion mediated by integrin
GO:0040007
IEA
Genome Projectgrowth
GO:0042060
ISS
Genome Projectwound healing
GO:0042416
ISS
IEA
Genome Projectdopamine biosynthetic process
GO:0042476
NAS
Genome Projectodontogenesis
GO:0042493
IDA
Genome Projectresponse to drug
GO:0042637
IDA
Genome Projectcatagen
GO:0042704
TAS
Genome Projectuterine wall breakdown
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0043525
IDA
Genome Projectpositive regulation of neuron apoptotic process
GO:0045216
IDA
Genome Projectcell-cell junction organization
GO:0045726
IDA
Genome Projectpositive regulation of integrin biosynthetic process
GO:0045778
IEP
Genome Projectpositive regulation of ossification
GO:0045787
ISS
IEA
Genome Projectpositive regulation of cell cycle
GO:0045823
IDA
Genome Projectpositive regulation of heart contraction
GO:0048103
ISS
IEA
Genome Projectsomatic stem cell division
GO:0048468
IBA
Genome Projectcell development
GO:0048566
IEP
Genome Projectembryonic digestive tract development
GO:0048663
IEA
Genome Projectneuron fate commitment
GO:0048666
ISS
IEA
Genome Projectneuron development
GO:0048699
TAS
Genome Projectgeneration of neurons
GO:0050680
IDA, IMP
Genome Projectnegative regulation of epithelial cell proliferation
GO:0050714
IDA
Genome Projectpositive regulation of protein secretion
GO:0050777
TAS
Genome Projectnegative regulation of immune response
GO:0050778
ISS
Genome Projectpositive regulation of immune response
GO:0051781
IEA
Genome Projectpositive regulation of cell division
GO:0051795
IDA
Genome Projectpositive regulation of catagen
GO:0051891
IDA
Genome Projectpositive regulation of cardioblast differentiation
GO:0060038
IDA
Genome Projectcardiac muscle cell proliferation
GO:0060317
IDA
Genome Projectcardiac epithelial to mesenchymal transition
GO:0060325
IEA
Genome Projectface morphogenesis
GO:0060389
IDA
Genome Projectpathway-restricted SMAD protein phosphorylation
GO:0060395
IBA
Genome ProjectSMAD protein signal transduction
GO:0061037
IEA
Genome Projectnegative regulation of cartilage development
GO:0070237
IEA
Genome Projectpositive regulation of activation-induced cell death of T cells
GO:0097191
IDA
Genome Projectextrinsic apoptotic signaling pathway
GO:1903053
IEA
Genome Projectregulation of extracellular matrix organization
GO:2001241
IEA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:1903659
IMP
Genome Projectregulation of complement-dependent cytotoxicity

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001540
IDA
Genome Projectbeta-amyloid binding
GO:0004702
IDA
Genome Projectreceptor signaling protein serine/threonine kinase activity
GO:0005102
IMP
Genome Projectreceptor binding
GO:0005114
IDA, IPI, IMP
Genome Projecttype II transforming growth factor beta receptor binding
GO:0005125
TAS
Genome Projectcytokine activity
GO:0005160
IDA
IEA
Genome Projecttransforming growth factor beta receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008083
IEA
Genome Projectgrowth factor activity
GO:0034714
IPI, IMP
Genome Projecttype III transforming growth factor beta receptor binding
GO:0042803
IDA
Genome Projectprotein homodimerization activity
GO:0046982
TAS
Genome Projectprotein heterodimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IDA
TAS, IEA
Genome Projectextracellular region
GO:0005615
IDA
IEA
Genome Projectextracellular space
GO:0005768
IEA
Genome Projectendosome
GO:0030424
ISS
IEA
Genome Projectaxon
GO:0031012
IDA
Genome Projectextracellular matrix
GO:0031093
TAS
Genome Projectplatelet alpha granule lumen
GO:0043025
ISS
IEA
Genome Projectneuronal cell body

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001111Transforming growth factor-beta, N-terminal
IPR001839Transforming growth factor-beta, C-terminal
IPR003940Transforming growth factor, beta 2
IPR015615Transforming growth factor-beta-related
IPR016319Transforming growth factor-beta
IPR017948Transforming growth factor beta, conserved site
IPR029034Cystine-knot cytokine

No MapMan annotations defined for this gene.