Gene: ENSG00000092820 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000092820
Transcript Identifier
ENST00000367075
Gene Type
Coding gene
Location
6 : 158766914-158818093 : negative

Family Information

Homologous gene family
HOM03P007566
(11 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P010170
(8 genes in 4 species)
specific family

Descriptions

gene_descr
ezrin

Identifiers

Type Value
pidENSP00000356042
HGNC12691
UniprotP15311

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IMP
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001951
IEA
Genome Projectintestinal D-glucose absorption
GO:0003376
IMP
Genome Projectsphingosine-1-phosphate signaling pathway
GO:0007016
NAS
Genome Projectcytoskeletal anchoring at plasma membrane
GO:0007159
IEP
Genome Projectleukocyte cell-cell adhesion
GO:0007411
TAS
Genome Projectaxon guidance
GO:0008360
IMP
IEA
Genome Projectregulation of cell shape
GO:0010628
IGI
Genome Projectpositive regulation of gene expression
GO:0010737
IMP
Genome Projectprotein kinase A signaling
GO:0022614
IEP
Genome Projectmembrane to membrane docking
GO:0030033
IMP
Genome Projectmicrovillus assembly
GO:0030855
IEA
Genome Projectepithelial cell differentiation
GO:0030953
IMP
Genome Projectastral microtubule organization
GO:0031532
IMP
Genome Projectactin cytoskeleton reorganization
GO:0031623
IEA
Genome Projectreceptor internalization
GO:0032532
IEA
Genome Projectregulation of microvillus length
GO:0034629
IMP
Genome Projectcellular protein complex localization
GO:0035088
IEA
Genome Projectestablishment or maintenance of apical/basal cell polarity
GO:0040018
IEA
Genome Projectpositive regulation of multicellular organism growth
GO:0043622
IMP
Genome Projectcortical microtubule organization
GO:0046847
IMP
IEA
Genome Projectfilopodium assembly
GO:0048015
IDA
Genome Projectphosphatidylinositol-mediated signaling
GO:0050714
IMP
Genome Projectpositive regulation of protein secretion
GO:0050860
IMP
Genome Projectnegative regulation of T cell receptor signaling pathway
GO:0051017
IDA
Genome Projectactin filament bundle assembly
GO:0051660
IMP
Genome Projectestablishment of centrosome localization
GO:0061028
IGI
Genome Projectestablishment of endothelial barrier
GO:0070373
IMP
Genome Projectnegative regulation of ERK1 and ERK2 cascade
GO:0071320
IMP
Genome Projectcellular response to cAMP
GO:0072697
IMP
Genome Projectprotein localization to cell cortex
GO:0090002
IMP
Genome Projectestablishment of protein localization to plasma membrane
GO:0090004
IEA
Genome Projectpositive regulation of establishment of protein localization to plasma membrane
GO:1900041
IMP
Genome Projectnegative regulation of interleukin-2 secretion
GO:1902115
IMP, IGI
Genome Projectregulation of organelle assembly
GO:1902896
IEA
Genome Projectterminal web assembly
GO:1902966
IGI
Genome Projectpositive regulation of protein localization to early endosome
GO:1903364
IGI
Genome Projectpositive regulation of cellular protein catabolic process
GO:1903753
IMP
Genome Projectnegative regulation of p38MAPK cascade
GO:2000643
IMP, IGI
Genome Projectpositive regulation of early endosome to late endosome transport
GO:0008361
IMP
Genome Projectregulation of cell size
GO:0022612
IMP
Genome Projectgland morphogenesis
GO:0032956
IMP
Genome Projectregulation of actin cytoskeleton organization
GO:0045198
IMP
Genome Projectestablishment of epithelial cell apical/basal polarity
GO:1901222
IMP
Genome Projectregulation of NIK/NF-kappaB signaling

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003779
IDA
IEA
Genome Projectactin binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008017
IMP
Genome Projectmicrotubule binding
GO:0008092
IEA
Genome Projectcytoskeletal protein binding
GO:0019904
IPI
IEA
Genome Projectprotein domain specific binding
GO:0032403
IEA
Genome Projectprotein complex binding
GO:0034236
IPI
Genome Projectprotein kinase A catalytic subunit binding
GO:0034237
IPI
Genome Projectprotein kinase A regulatory subunit binding
GO:0044548
IPI
Genome ProjectS100 protein binding
GO:0044822
IDA
Genome Projectpoly(A) RNA binding
GO:0050839
IPI
Genome Projectcell adhesion molecule binding
GO:0051015
IDA
Genome Projectactin filament binding
GO:0051117
IPI
Genome ProjectATPase binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001726
IDA
Genome Projectruffle
GO:0001772
IDA
Genome Projectimmunological synapse
GO:0001931
IEA
Genome Projecturopod
GO:0005615
IDA
Genome Projectextracellular space
GO:0005622
IEA
Genome Projectintracellular
GO:0005730
IDA
Genome Projectnucleolus
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005768
IDA
Genome Projectendosome
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005884
IDA
Genome Projectactin filament
GO:0005886
IDA
IEA
Genome Projectplasma membrane
GO:0005902
IDA
Genome Projectmicrovillus
GO:0005903
ISS
IEA
Genome Projectbrush border
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0005938
IEA
Genome Projectcell cortex
GO:0015629
IDA
Genome Projectactin cytoskeleton
GO:0016020
IDA
IEA
Genome Projectmembrane
GO:0016323
ISS
IEA
Genome Projectbasolateral plasma membrane
GO:0016324
IDA
IEA
Genome Projectapical plasma membrane
GO:0019898
IDA
IEA
Genome Projectextrinsic component of membrane
GO:0030175
IDA
IEA
Genome Projectfilopodium
GO:0030315
IEA
Genome ProjectT-tubule
GO:0030863
TAS
Genome Projectcortical cytoskeleton
GO:0031528
IEA
Genome Projectmicrovillus membrane
GO:0031982
IDA
Genome Projectvesicle
GO:0032587
IEA
Genome Projectruffle membrane
GO:0036064
IEA
Genome Projectciliary basal body
GO:0042995
IDA
IEA
Genome Projectcell projection
GO:0043209
IEA
Genome Projectmyelin sheath
GO:0044297
IEA
Genome Projectcell body
GO:0044393
IEA
Genome Projectmicrospike
GO:0044853
IDA
Genome Projectplasma membrane raft
GO:0045121
IEA
Genome Projectmembrane raft
GO:0045177
IDA
Genome Projectapical part of cell
GO:0048471
IDA
Genome Projectperinuclear region of cytoplasm
GO:0051286
IEA
Genome Projectcell tip
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0071944
IDA
Genome Projectcell periphery
GO:0097449
IEA
Genome Projectastrocyte projection
GO:0097454
IEA
Genome ProjectSchwann cell microvillus
GO:0098592
IDA
Genome Projectcytoplasmic side of apical plasma membrane
GO:0036398
IDA
Genome ProjectTCR signalosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000299FERM domain
IPR000798Ezrin/radixin/moesin-like
IPR008954Moesin tail domain
IPR011174Ezrin/radixin/moesin
IPR011259Ezrin/radixin/moesin, C-terminal
IPR011993PH domain-like
IPR014352FERM/acyl-CoA-binding protein, 3-helical bundle
IPR018979FERM, N-terminal
IPR018980FERM, C-terminal PH-like domain
IPR019747FERM conserved site
IPR019748FERM central domain
IPR019749Band 4.1 domain
IPR029071Ubiquitin-related domain

No MapMan annotations defined for this gene.