Gene: ENSG00000092445 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000092445
Transcript Identifier
ENST00000263798
Gene Type
Coding gene
Location
15 : 41559258-41578276 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P017320
(5 genes in 2 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
TYRO3 protein tyrosine kinase

Identifiers

Type Value
pidENSP00000263798
HGNC12446
UniprotQ06418

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001779
IEA
Genome Projectnatural killer cell differentiation
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0007155
NAS, IEA
Genome Projectcell adhesion
GO:0007165
NAS
Genome Projectsignal transduction
GO:0007283
ISS
IEA
Genome Projectspermatogenesis
GO:0014065
NAS
Genome Projectphosphatidylinositol 3-kinase signaling
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018108
IDA
NAS, IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0021885
ISS
IEA
Genome Projectforebrain cell migration
GO:0023014
NAS
Genome Projectsignal transduction by protein phosphorylation
GO:0030168
ISS
IEA
Genome Projectplatelet activation
GO:0032940
ISS
IEA
Genome Projectsecretion by cell
GO:0034122
ISS
IEA
Genome Projectnegative regulation of toll-like receptor signaling pathway
GO:0034446
ISS
IEA
Genome Projectsubstrate adhesion-dependent cell spreading
GO:0042698
ISS
IEA
Genome Projectovulation cycle
GO:0043277
ISS
IEA
Genome Projectapoptotic cell clearance
GO:0043491
ISS
IEA
Genome Projectprotein kinase B signaling
GO:0043524
ISS
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0045824
ISS
IEA
Genome Projectnegative regulation of innate immune response
GO:0046777
IDA
Genome Projectprotein autophosphorylation
GO:0050728
ISS
IEA
Genome Projectnegative regulation of inflammatory response
GO:0051250
IEA
Genome Projectnegative regulation of lymphocyte activation
GO:0060068
IEA
Genome Projectvagina development
GO:0070050
ISS
IEA
Genome Projectneuron cellular homeostasis
GO:0070527
ISS
IEA
Genome Projectplatelet aggregation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
IDA
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004714
NAS, IEA
Genome Projecttransmembrane receptor protein tyrosine kinase activity
GO:0004716
NAS
Genome Projectreceptor signaling protein tyrosine kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0043548
IPI
Genome Projectphosphatidylinositol 3-kinase binding
GO:0046982
IEA
Genome Projectprotein heterodimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
ISS
Genome Projectnucleus
GO:0005635
ISS
Genome Projectnuclear envelope
GO:0005789
ISS
Genome Projectendoplasmic reticulum membrane
GO:0005886
IEA
Genome Projectplasma membrane
GO:0005887
NAS
Genome Projectintegral component of plasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR003598Immunoglobulin subtype 2
IPR003599Immunoglobulin subtype
IPR003961Fibronectin type III
IPR007110Immunoglobulin-like domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR013098Immunoglobulin I-set
IPR013783Immunoglobulin-like fold
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain

No MapMan annotations defined for this gene.