Gene: ENSG00000091831 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000091831
Transcript Identifier
ENST00000206249
Gene Type
Coding gene
Location
6 : 151807913-152098966 : positive

Family Information

Homologous gene family
HOM03P000128
(228 genes in 4 species)
specific family

Descriptions

gene_descr
estrogen receptor 1

Identifiers

Type Value
pidENSP00000206249
HGNC3467
UniprotP03372
UniprotG4XH65

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001547
IEA
Genome Projectantral ovarian follicle growth
GO:0002064
IEA
Genome Projectepithelial cell development
GO:0006351
TAS, IEA
Genome Projecttranscription, DNA-templated
GO:0006355
NAS, IEA
Genome Projectregulation of transcription, DNA-templated
GO:0008209
IEA
Genome Projectandrogen metabolic process
GO:0008584
IEA
Genome Projectmale gonad development
GO:0030522
IEA
Genome Projectintracellular receptor signaling pathway
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0043401
IEA
Genome Projectsteroid hormone mediated signaling pathway
GO:0048146
IEA
Genome Projectpositive regulation of fibroblast proliferation
GO:0060065
IEA
Genome Projectuterus development
GO:0060068
IEA
Genome Projectvagina development
GO:0060523
IEA
Genome Projectprostate epithelial cord elongation
GO:0060527
IEA
Genome Projectprostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060687
IEA
Genome Projectregulation of branching involved in prostate gland morphogenesis
GO:0060745
IEA
Genome Projectmammary gland branching involved in pregnancy
GO:0060749
IEA
Genome Projectmammary gland alveolus development
GO:0060750
IEA
Genome Projectepithelial cell proliferation involved in mammary gland duct elongation
GO:0071391
IEA
Genome Projectcellular response to estrogen stimulus
GO:0006338
NAS
Genome Projectchromatin remodeling
GO:0006366
IDA
Genome Projecttranscription from RNA polymerase II promoter
GO:0006367
TAS
Genome Projecttranscription initiation from RNA polymerase II promoter
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007200
ISS
Genome Projectphospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204
ISS
Genome Projectpositive regulation of cytosolic calcium ion concentration
GO:0010467
TAS
Genome Projectgene expression
GO:0010629
IDA
Genome Projectnegative regulation of gene expression
GO:0010863
ISS
Genome Projectpositive regulation of phospholipase C activity
GO:0030518
ISS
Genome Projectintracellular steroid hormone receptor signaling pathway
GO:0030520
NAS
Genome Projectintracellular estrogen receptor signaling pathway
GO:0032355
IDA
Genome Projectresponse to estradiol
GO:0043124
IDA
Genome Projectnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043433
IDA
Genome Projectnegative regulation of sequence-specific DNA binding transcription factor activity
GO:0043627
IDA
Genome Projectresponse to estrogen
GO:0045429
IDA
Genome Projectpositive regulation of nitric oxide biosynthetic process
GO:0045893
IDA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0051000
IDA
Genome Projectpositive regulation of nitric-oxide synthase activity
GO:0051091
IDA
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0071392
IDA
ISS
Genome Projectcellular response to estradiol stimulus

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003677
IEA
Genome ProjectDNA binding
GO:0003700
NAS, IEA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0003707
TAS, IEA
Genome Projectsteroid hormone receptor activity
GO:0004879
IEA
Genome ProjectRNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0005496
ISS
IEA
Genome Projectsteroid binding
GO:0008270
IEA
Genome Projectzinc ion binding
GO:0008289
IEA
Genome Projectlipid binding
GO:0030284
NAS, IEA
Genome Projectestrogen receptor activity
GO:0043565
IEA
Genome Projectsequence-specific DNA binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0000978
IDA
Genome ProjectRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001046
IDA
Genome Projectcore promoter sequence-specific DNA binding
GO:0001077
IDA
Genome Projecttranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003682
IDA
Genome Projectchromatin binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008013
IPI
Genome Projectbeta-catenin binding
GO:0008134
IPI
Genome Projecttranscription factor binding
GO:0019899
IPI
Genome Projectenzyme binding
GO:0030235
NAS
Genome Projectnitric-oxide synthase regulator activity
GO:0034056
IDA
Genome Projectestrogen response element binding
GO:0038052
IDA, IGI
Genome ProjectRNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0051117
IDA
Genome ProjectATPase binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0000790
IDA
Genome Projectnuclear chromatin
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005794
IEA
Genome ProjectGolgi apparatus
GO:0005829
ISS
Genome Projectcytosol
GO:0005886
IDA
IEA
Genome Projectplasma membrane
GO:0016020
NAS, IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0035327
IDA
Genome Projecttranscriptionally active chromatin

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000536Nuclear hormone receptor, ligand-binding domain
IPR001292Oestrogen receptor
IPR001628Zinc finger, nuclear hormone receptor-type
IPR001723Nuclear hormone receptor
IPR013088Zinc finger, NHR/GATA-type
IPR024178Oestrogen receptor/oestrogen-related receptor
IPR024736Oestrogen-type nuclear receptor final C-terminal domain

No MapMan annotations defined for this gene.