Gene: ENSG00000090432 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000090432
Transcript Identifier
ENST00000264198
Gene Type
Coding gene
Location
1 : 20500690-20508024 : negative

Family Information

Homologous gene family
HOM03P023734
(3 genes in 3 species)
specific family

Descriptions

gene_descr
mitochondrial E3 ubiquitin protein ligase 1

Identifiers

Type Value
pidENSP00000264198
HGNC25762
UniprotQ969V5
UniprotA0A024RAA0

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0007005
IEA
Genome Projectmitochondrion organization
GO:0016567
IDA
IEA
Genome Projectprotein ubiquitination
GO:0031647
IEA
Genome Projectregulation of protein stability
GO:0051881
IEA
Genome Projectregulation of mitochondrial membrane potential
GO:1903861
IEA
Genome Projectpositive regulation of dendrite extension
GO:0000266
IMP
Genome Projectmitochondrial fission
GO:0006915
IEA
Genome Projectapoptotic process
GO:0006919
IDA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007257
IDA
Genome Projectactivation of JUN kinase activity
GO:0010637
IDA
Genome Projectnegative regulation of mitochondrial fusion
GO:0010821
IMP
Genome Projectregulation of mitochondrion organization
GO:0016925
IEA
Genome Projectprotein sumoylation
GO:0030308
IDA
Genome Projectnegative regulation of cell growth
GO:0031648
IMP
Genome Projectprotein destabilization
GO:0033235
IDA
Genome Projectpositive regulation of protein sumoylation
GO:0043123
IMP
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824
IMP
Genome Projectnegative regulation of innate immune response
GO:0050689
IMP
Genome Projectnegative regulation of defense response to virus by host
GO:0050821
IMP
Genome Projectprotein stabilization
GO:0051646
IMP
Genome Projectmitochondrion localization
GO:0051898
IDA
Genome Projectnegative regulation of protein kinase B signaling
GO:0060339
IMP
Genome Projectnegative regulation of type I interferon-mediated signaling pathway
GO:0071360
IDA
Genome Projectcellular response to exogenous dsRNA
GO:0071650
IMP
Genome Projectnegative regulation of chemokine (C-C motif) ligand 5 production
GO:0090141
IDA
Genome Projectpositive regulation of mitochondrial fission
GO:1901028
IDA
Genome Projectregulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004842
IDA
IEA
Genome Projectubiquitin-protein transferase activity
GO:0008270
IEA
Genome Projectzinc ion binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0004871
IMP
Genome Projectsignal transducer activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0016874
IEA
Genome Projectligase activity
GO:0019789
IDA
Genome ProjectSUMO transferase activity
GO:0031625
IPI
Genome Projectubiquitin protein ligase binding
GO:0042802
IPI
Genome Projectidentical protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005654
IDA
Genome Projectnucleoplasm
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005739
IDA, IMP
IEA
Genome Projectmitochondrion
GO:0005741
IEA
Genome Projectmitochondrial outer membrane
GO:0005777
IDA
IEA
Genome Projectperoxisome
GO:0016020
IDA
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0030424
IMP
Genome Projectaxon
GO:0031307
IDA
Genome Projectintegral component of mitochondrial outer membrane
GO:0043025
IMP
Genome Projectneuronal cell body

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001841Zinc finger, RING-type
IPR013083Zinc finger, RING/FYVE/PHD-type
IPR022170Mitochondrial ubiquitin ligase activator of NFKB 1

No MapMan annotations defined for this gene.