Gene: ENSG00000090020 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000090020
Transcript Identifier
ENST00000263980
Gene Type
Coding gene
Location
1 : 27100307-27154334 : negative

Family Information

Homologous gene family
HOM03P000250
(148 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P017995
(5 genes in 2 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1

Identifiers

Type Value
pidENSP00000263980
HGNC11071
UniprotP19634

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002026
IEA
Genome Projectregulation of the force of heart contraction
GO:0005975
TAS
Genome Projectcarbohydrate metabolic process
GO:0006810
IEA
Genome Projecttransport
GO:0006811
TAS, IEA
Genome Projection transport
GO:0006812
IEA
Genome Projectcation transport
GO:0006814
IEA
Genome Projectsodium ion transport
GO:0006883
IDA
Genome Projectcellular sodium ion homeostasis
GO:0006885
IDA
TAS, IEA
Genome Projectregulation of pH
GO:0010447
IDA
Genome Projectresponse to acidic pH
GO:0010613
IMP
Genome Projectpositive regulation of cardiac muscle hypertrophy
GO:0010882
IMP
Genome Projectregulation of cardiac muscle contraction by calcium ion signaling
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0016049
IEA
Genome Projectcell growth
GO:0016477
TAS
Genome Projectcell migration
GO:0030011
TAS
Genome Projectmaintenance of cell polarity
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030203
TAS
Genome Projectglycosaminoglycan metabolic process
GO:0030212
TAS
Genome Projecthyaluronan metabolic process
GO:0030214
TAS
Genome Projecthyaluronan catabolic process
GO:0030307
IEA
Genome Projectpositive regulation of cell growth
GO:0032869
IEA
Genome Projectcellular response to insulin stimulus
GO:0035794
IEA
Genome Projectpositive regulation of mitochondrial membrane permeability
GO:0035994
IMP
Genome Projectresponse to muscle stretch
GO:0042493
IEA
Genome Projectresponse to drug
GO:0043065
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043066
IEA
Genome Projectnegative regulation of apoptotic process
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0045760
IEA
Genome Projectpositive regulation of action potential
GO:0045944
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0051259
ISS
Genome Projectprotein oligomerization
GO:0051453
IDA
Genome Projectregulation of intracellular pH
GO:0051492
TAS
Genome Projectregulation of stress fiber assembly
GO:0051533
IDA
Genome Projectpositive regulation of NFAT protein import into nucleus
GO:0051893
TAS
Genome Projectregulation of focal adhesion assembly
GO:0051930
IEA
Genome Projectregulation of sensory perception of pain
GO:0055007
IEA
Genome Projectcardiac muscle cell differentiation
GO:0055085
TAS, IEA
Genome Projecttransmembrane transport
GO:0070886
IDA
Genome Projectpositive regulation of calcineurin-NFAT signaling cascade
GO:0070997
IEA
Genome Projectneuron death
GO:0071236
IEA
Genome Projectcellular response to antibiotic
GO:0071257
IEA
Genome Projectcellular response to electrical stimulus
GO:0071260
TAS
Genome Projectcellular response to mechanical stimulus
GO:0071407
IEA
Genome Projectcellular response to organic cyclic compound
GO:0071436
ISS
Genome Projectsodium ion export
GO:0071456
IEA
Genome Projectcellular response to hypoxia
GO:0071468
IDA
ISS
Genome Projectcellular response to acidic pH
GO:0071872
IMP
Genome Projectcellular response to epinephrine stimulus
GO:0086003
IEA
Genome Projectcardiac muscle cell contraction
GO:0086036
TAS
Genome Projectregulation of cardiac muscle cell membrane potential
GO:0086092
IMP
Genome Projectregulation of the force of heart contraction by cardiac conduction
GO:0098719
IDA
Genome Projectsodium ion import across plasma membrane
GO:0098735
IMP
Genome Projectpositive regulation of the force of heart contraction
GO:1902533
IEA
Genome Projectpositive regulation of intracellular signal transduction
GO:1902600
IDA
Genome Projecthydrogen ion transmembrane transport
GO:1903281
IMP
Genome Projectpositive regulation of calcium:sodium antiporter activity

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005515
IPI
Genome Projectprotein binding
GO:0005516
IEA
Genome Projectcalmodulin binding
GO:0005546
TAS
Genome Projectphosphatidylinositol-4,5-bisphosphate binding
GO:0015297
IEA
Genome Projectantiporter activity
GO:0015299
TAS, IEA
Genome Projectsolute:proton antiporter activity
GO:0015385
IDA
ISS
IEA
Genome Projectsodium:proton antiporter activity
GO:0030346
IDA, IPI
Genome Projectprotein phosphatase 2B binding
GO:0030674
TAS
Genome Projectprotein binding, bridging
GO:0032947
TAS
Genome Projectprotein complex scaffold
GO:0048306
IDA
Genome Projectcalcium-dependent protein binding
GO:0086040
TAS
Genome Projectsodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005654
IDA
Genome Projectnucleoplasm
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005739
IEA
Genome Projectmitochondrion
GO:0005783
ISS
IEA
Genome Projectendoplasmic reticulum
GO:0005789
IEA
Genome Projectendoplasmic reticulum membrane
GO:0005886
IDA
TAS, IEA
Genome Projectplasma membrane
GO:0005887
IDA
Genome Projectintegral component of plasma membrane
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0009986
IEA
Genome Projectcell surface
GO:0014704
IEA
Genome Projectintercalated disc
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
TAS, IEA
Genome Projectintegral component of membrane
GO:0016323
IEA
Genome Projectbasolateral plasma membrane
GO:0016324
IEA
Genome Projectapical plasma membrane
GO:0030027
TAS
Genome Projectlamellipodium
GO:0030315
IEA
Genome ProjectT-tubule
GO:0042383
IEA
Genome Projectsarcolemma
GO:0045121
IDA
IEA
Genome Projectmembrane raft
GO:0048471
IEA
Genome Projectperinuclear region of cytoplasm
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0090533
IDA
Genome Projectcation-transporting ATPase complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001970Na+/H+ exchanger, isoform 1 (NHE1)
IPR004709Na+/H+ exchanger
IPR006153Cation/H+ exchanger
IPR018422Cation/H+ exchanger, CPA1 family
IPR032103Sodium/hydrogen exchanger, regulatory region

No MapMan annotations defined for this gene.