Gene: ENSG00000084207 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000084207
Transcript Identifier
ENST00000398606
Gene Type
Coding gene
Location
11 : 67583844-67586577 : positive

Family Information

Homologous gene family
HOM03P003080
(31 genes in 13 species)
specific family

Descriptions

gene_descr
glutathione S-transferase pi 1

Identifiers

Type Value
pidENSP00000381607
HGNC4638
UniprotP09211
UniprotV9HWE9

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000302
ISS
TAS
Genome Projectresponse to reactive oxygen species
GO:0002674
NAS
Genome Projectnegative regulation of acute inflammatory response
GO:0006469
IDA
Genome Projectnegative regulation of protein kinase activity
GO:0006749
IDA
Genome Projectglutathione metabolic process
GO:0006805
IDA
TAS
Genome Projectxenobiotic metabolic process
GO:0007417
TAS
Genome Projectcentral nervous system development
GO:0008152
IEA
Genome Projectmetabolic process
GO:0009890
IDA
Genome Projectnegative regulation of biosynthetic process
GO:0010804
IC
Genome Projectnegative regulation of tumor necrosis factor-mediated signaling pathway
GO:0032691
IDA
Genome Projectnegative regulation of interleukin-1 beta production
GO:0032720
IDA
Genome Projectnegative regulation of tumor necrosis factor production
GO:0032872
ISS
Genome Projectregulation of stress-activated MAPK cascade
GO:0032873
ISS
Genome Projectnegative regulation of stress-activated MAPK cascade
GO:0032930
ISS
Genome Projectpositive regulation of superoxide anion generation
GO:0035726
ISS
Genome Projectcommon myeloid progenitor cell proliferation
GO:0035732
NAS
Genome Projectnitric oxide storage
GO:0043066
TAS
Genome Projectnegative regulation of apoptotic process
GO:0043124
ISS
Genome Projectnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043407
IDA
Genome Projectnegative regulation of MAP kinase activity
GO:0043409
NAS
Genome Projectnegative regulation of MAPK cascade
GO:0043508
IDA
Genome Projectnegative regulation of JUN kinase activity
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0048147
ISS
Genome Projectnegative regulation of fibroblast proliferation
GO:0051771
IDA
Genome Projectnegative regulation of nitric-oxide synthase biosynthetic process
GO:0070372
ISS
Genome Projectregulation of ERK1 and ERK2 cascade
GO:0070373
IDA
Genome Projectnegative regulation of ERK1 and ERK2 cascade
GO:0070664
ISS
Genome Projectnegative regulation of leukocyte proliferation
GO:0071222
ISS
Genome Projectcellular response to lipopolysaccharide
GO:0071638
IDA
Genome Projectnegative regulation of monocyte chemotactic protein-1 production
GO:1901687
TAS
Genome Projectglutathione derivative biosynthetic process
GO:2001237
IDA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004364
IDA
IEA
Genome Projectglutathione transferase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008432
ISS
Genome ProjectJUN kinase binding
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019207
ISS
Genome Projectkinase regulator activity
GO:0035730
IDA
Genome ProjectS-nitrosoglutathione binding
GO:0035731
IDA
Genome Projectdinitrosyl-iron complex binding
GO:0070026
NAS
Genome Projectnitric oxide binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005615
IDA
Genome Projectextracellular space
GO:0005622
IDA
Genome Projectintracellular
GO:0005634
IEA
Genome Projectnucleus
GO:0005737
IDA
TAS, IEA
Genome Projectcytoplasm
GO:0005739
IDA
IEA
Genome Projectmitochondrion
GO:0005829
TAS
Genome Projectcytosol
GO:0005886
IDA
Genome Projectplasma membrane
GO:0031982
IDA
Genome Projectvesicle
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0097057
IDA
Genome ProjectTRAF2-GSTP1 complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003082Glutathione S-transferase, Pi class
IPR004045Glutathione S-transferase, N-terminal
IPR004046Glutathione S-transferase, C-terminal
IPR010987Glutathione S-transferase, C-terminal-like
IPR012336Thioredoxin-like fold

No MapMan annotations defined for this gene.