Gene: ENSG00000081189 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000081189
Transcript Identifier
ENST00000340208
Gene Type
Coding gene
Location
5 : 88722604-88823788 : negative

Family Information

Homologous gene family
HOM03P000139
(214 genes in 26 species)
specific family
Orthologous gene family
ORTHO03P071894
(2 genes in 2 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
myocyte enhancer factor 2C

Identifiers

Type Value
pidENSP00000340874
HGNC6996
UniprotQ06413

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IMP
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0000165
IDA, IMP
Genome ProjectMAPK cascade
GO:0001568
ISS
Genome Projectblood vessel development
GO:0001649
ISS
Genome Projectosteoblast differentiation
GO:0001764
ISS
Genome Projectneuron migration
GO:0001782
ISS
Genome ProjectB cell homeostasis
GO:0001947
ISS
Genome Projectheart looping
GO:0001958
ISS
Genome Projectendochondral ossification
GO:0001974
ISS
Genome Projectblood vessel remodeling
GO:0002062
ISS
Genome Projectchondrocyte differentiation
GO:0002224
TAS
Genome Projecttoll-like receptor signaling pathway
GO:0002467
ISS
Genome Projectgerminal center formation
GO:0002634
ISS
Genome Projectregulation of germinal center formation
GO:0002755
TAS
Genome ProjectMyD88-dependent toll-like receptor signaling pathway
GO:0002756
TAS
Genome ProjectMyD88-independent toll-like receptor signaling pathway
GO:0002931
ISS
Genome Projectresponse to ischemia
GO:0003138
ISS
Genome Projectprimary heart field specification
GO:0003139
ISS
Genome Projectsecondary heart field specification
GO:0003151
ISS
Genome Projectoutflow tract morphogenesis
GO:0003185
ISS
Genome Projectsinoatrial valve morphogenesis
GO:0003211
ISS
Genome Projectcardiac ventricle formation
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IDA
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006366
IDA
Genome Projecttranscription from RNA polymerase II promoter
GO:0006915
IEA
Genome Projectapoptotic process
GO:0006959
ISS
Genome Projecthumoral immune response
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007399
TAS, IEA
Genome Projectnervous system development
GO:0007507
IEP
ISS
NAS
Genome Projectheart development
GO:0007517
TAS
Genome Projectmuscle organ development
GO:0007519
ISS
Genome Projectskeletal muscle tissue development
GO:0007521
ISS
Genome Projectmuscle cell fate determination
GO:0007611
ISS
Genome Projectlearning or memory
GO:0009615
IEP
Genome Projectresponse to virus
GO:0010628
IDA
Genome Projectpositive regulation of gene expression
GO:0010629
ISS
Genome Projectnegative regulation of gene expression
GO:0010694
ISS
Genome Projectpositive regulation of alkaline phosphatase activity
GO:0014033
ISS
Genome Projectneural crest cell differentiation
GO:0014902
IEP
Genome Projectmyotube differentiation
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030182
IEP
ISS
Genome Projectneuron differentiation
GO:0030220
ISS
Genome Projectplatelet formation
GO:0030279
IDA
Genome Projectnegative regulation of ossification
GO:0030318
ISS
Genome Projectmelanocyte differentiation
GO:0030501
ISS
Genome Projectpositive regulation of bone mineralization
GO:0030890
ISS
Genome Projectpositive regulation of B cell proliferation
GO:0034134
TAS
Genome Projecttoll-like receptor 2 signaling pathway
GO:0034138
TAS
Genome Projecttoll-like receptor 3 signaling pathway
GO:0034142
TAS
Genome Projecttoll-like receptor 4 signaling pathway
GO:0034146
TAS
Genome Projecttoll-like receptor 5 signaling pathway
GO:0034162
TAS
Genome Projecttoll-like receptor 9 signaling pathway
GO:0034166
TAS
Genome Projecttoll-like receptor 10 signaling pathway
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0035690
ISS
Genome Projectcellular response to drug
GO:0035984
ISS
Genome Projectcellular response to trichostatin A
GO:0038123
TAS
Genome Projecttoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124
TAS
Genome Projecttoll-like receptor TLR6:TLR2 signaling pathway
GO:0042100
ISS
Genome ProjectB cell proliferation
GO:0042692
TAS
Genome Projectmuscle cell differentiation
GO:0043406
ISS
Genome Projectpositive regulation of MAP kinase activity
GO:0043523
ISS
Genome Projectregulation of neuron apoptotic process
GO:0043524
ISS
Genome Projectnegative regulation of neuron apoptotic process
GO:0045087
TAS
Genome Projectinnate immune response
GO:0045652
ISS
Genome Projectregulation of megakaryocyte differentiation
GO:0045663
IMP
Genome Projectpositive regulation of myoblast differentiation
GO:0045666
ISS
Genome Projectpositive regulation of neuron differentiation
GO:0045669
ISS
Genome Projectpositive regulation of osteoblast differentiation
GO:0045893
IDA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA, IMP
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046928
ISS
Genome Projectregulation of neurotransmitter secretion
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048167
ISS
Genome Projectregulation of synaptic plasticity
GO:0048643
IMP
Genome Projectpositive regulation of skeletal muscle tissue development
GO:0048666
ISS
Genome Projectneuron development
GO:0048667
ISS
Genome Projectcell morphogenesis involved in neuron differentiation
GO:0050853
ISS
Genome ProjectB cell receptor signaling pathway
GO:0051145
ISS
Genome Projectsmooth muscle cell differentiation
GO:0051149
TAS
Genome Projectpositive regulation of muscle cell differentiation
GO:0051403
TAS
Genome Projectstress-activated MAPK cascade
GO:0051963
ISS
Genome Projectregulation of synapse assembly
GO:0051966
ISS
Genome Projectregulation of synaptic transmission, glutamatergic
GO:0055012
ISS
Genome Projectventricular cardiac muscle cell differentiation
GO:0060025
ISS
Genome Projectregulation of synaptic activity
GO:0060045
ISS
Genome Projectpositive regulation of cardiac muscle cell proliferation
GO:0060079
ISS
Genome Projectexcitatory postsynaptic potential
GO:0060998
ISS
Genome Projectregulation of dendritic spine development
GO:0061333
ISS
Genome Projectrenal tubule morphogenesis
GO:0071222
ISS
Genome Projectcellular response to lipopolysaccharide
GO:0071277
ISS
Genome Projectcellular response to calcium ion
GO:0071374
IDA
Genome Projectcellular response to parathyroid hormone stimulus
GO:0071498
ISS
Genome Projectcellular response to fluid shear stress
GO:0071560
IDA
Genome Projectcellular response to transforming growth factor beta stimulus
GO:0072102
ISS
Genome Projectglomerulus morphogenesis
GO:0072160
ISS
Genome Projectnephron tubule epithelial cell differentiation
GO:0090073
ISS
Genome Projectpositive regulation of protein homodimerization activity
GO:2000111
ISS
Genome Projectpositive regulation of macrophage apoptotic process
GO:2000310
ISS
Genome Projectregulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000311
ISS
Genome Projectregulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:2000727
IDA
Genome Projectpositive regulation of cardiac muscle cell differentiation
GO:2000987
ISS
Genome Projectpositive regulation of behavioral fear response
GO:2001013
ISS
Genome Projectepithelial cell proliferation involved in renal tubule morphogenesis
GO:2001016
IDA
Genome Projectpositive regulation of skeletal muscle cell differentiation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000977
IDA
Genome ProjectRNA polymerase II regulatory region sequence-specific DNA binding
GO:0000981
ISS
Genome ProjectRNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0000983
IDA
Genome Projecttranscription factor activity, RNA polymerase II core promoter sequence-specific
GO:0001077
IDA
Genome Projecttranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677
IDA
IEA
Genome ProjectDNA binding
GO:0003680
IDA
Genome ProjectAT DNA binding
GO:0003700
IDA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0033613
IPI
Genome Projectactivating transcription factor binding
GO:0035198
IDA
Genome ProjectmiRNA binding
GO:0044212
ISS
Genome Projecttranscription regulatory region DNA binding
GO:0046982
IPI
Genome Projectprotein heterodimerization activity
GO:0046983
IEA
Genome Projectprotein dimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005829
ISS
Genome Projectcytosol
GO:0016607
IDA
Genome Projectnuclear speck
GO:0043231
IDA
Genome Projectintracellular membrane-bounded organelle
GO:0043234
IDA
Genome Projectprotein complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR002100Transcription factor, MADS-box
IPR022102Holliday junction regulator protein family C-terminal

No MapMan annotations defined for this gene.