Gene: ENSG00000075891 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000075891
Transcript Identifier
ENST00000428433
Gene Type
Coding gene
Location
10 : 100746261-100827619 : positive

Family Information

Homologous gene family
HOM03P000330
(126 genes in 5 species)
specific family
Orthologous gene family
ORTHO03P070878
(2 genes in 2 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
paired box 2

Identifiers

Type Value
pidENSP00000396259
HGNC8616
UniprotQ02962

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001655
ISS
Genome Projecturogenital system development
GO:0001658
IEP
ISS
Genome Projectbranching involved in ureteric bud morphogenesis
GO:0001709
ISS
Genome Projectcell fate determination
GO:0001823
ISS
Genome Projectmesonephros development
GO:0001843
ISS
Genome Projectneural tube closure
GO:0002072
ISS
Genome Projectoptic cup morphogenesis involved in camera-type eye development
GO:0003337
ISS
Genome Projectmesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003406
ISS
Genome Projectretinal pigment epithelium development
GO:0006351
ISS
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006366
TAS
Genome Projecttranscription from RNA polymerase II promoter
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007409
TAS
Genome Projectaxonogenesis
GO:0007501
ISS
Genome Projectmesodermal cell fate specification
GO:0007568
IEA
Genome Projectaging
GO:0007601
TAS
Genome Projectvisual perception
GO:0008284
IEA
Genome Projectpositive regulation of cell proliferation
GO:0010001
ISS
Genome Projectglial cell differentiation
GO:0021554
ISS
Genome Projectoptic nerve development
GO:0021631
ISS
Genome Projectoptic nerve morphogenesis
GO:0021633
ISS
Genome Projectoptic nerve structural organization
GO:0021650
ISS
Genome Projectvestibulocochlear nerve formation
GO:0030154
IEA
Genome Projectcell differentiation
GO:0031667
IEA
Genome Projectresponse to nutrient levels
GO:0035566
IMP
Genome Projectregulation of metanephros size
GO:0035799
ISS
Genome Projectureter maturation
GO:0039003
ISS
Genome Projectpronephric field specification
GO:0042472
ISS
Genome Projectinner ear morphogenesis
GO:0043010
ISS
Genome Projectcamera-type eye development
GO:0043066
IDA, IMP
Genome Projectnegative regulation of apoptotic process
GO:0043069
ISS
Genome Projectnegative regulation of programmed cell death
GO:0043154
IDA
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043491
ISS
Genome Projectprotein kinase B signaling
GO:0045892
IMP
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IDA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045918
IMP
Genome Projectnegative regulation of cytolysis
GO:0045944
IDA
ISS
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048513
IEA
Genome Projectorgan development
GO:0048793
ISS
Genome Projectpronephros development
GO:0048854
ISS
Genome Projectbrain morphogenesis
GO:0048863
ISS
Genome Projectstem cell differentiation
GO:0050679
IDA
Genome Projectpositive regulation of epithelial cell proliferation
GO:0055114
ISS
Genome Projectoxidation-reduction process
GO:0060231
ISS
Genome Projectmesenchymal to epithelial transition
GO:0061360
ISS
Genome Projectoptic chiasma development
GO:0070301
ISS
Genome Projectcellular response to hydrogen peroxide
GO:0071300
ISS
Genome Projectcellular response to retinoic acid
GO:0071333
ISS
Genome Projectcellular response to glucose stimulus
GO:0071364
IEA
Genome Projectcellular response to epidermal growth factor stimulus
GO:0072075
ISS
Genome Projectmetanephric mesenchyme development
GO:0072108
ISS
Genome Projectpositive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0072162
ISS
Genome Projectmetanephric mesenchymal cell differentiation
GO:0072179
ISS
Genome Projectnephric duct formation
GO:0072189
ISS
Genome Projectureter development
GO:0072205
ISS
Genome Projectmetanephric collecting duct development
GO:0072207
IEP
Genome Projectmetanephric epithelium development
GO:0072221
ISS
Genome Projectmetanephric distal convoluted tubule development
GO:0072289
ISS
Genome Projectmetanephric nephron tubule formation
GO:0072300
ISS
Genome Projectpositive regulation of metanephric glomerulus development
GO:0072305
ISS
Genome Projectnegative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
GO:0072307
ISS
Genome Projectregulation of metanephric nephron tubule epithelial cell differentiation
GO:0072593
ISS
Genome Projectreactive oxygen species metabolic process
GO:0090102
ISS
Genome Projectcochlea development
GO:0090103
ISS
Genome Projectcochlea morphogenesis
GO:0090190
ISS
Genome Projectpositive regulation of branching involved in ureteric bud morphogenesis
GO:1900212
ISS
Genome Projectnegative regulation of mesenchymal cell apoptotic process involved in metanephros development
GO:1900215
ISS
Genome Projectnegative regulation of apoptotic process involved in metanephric collecting duct development
GO:1900218
ISS
Genome Projectnegative regulation of apoptotic process involved in metanephric nephron tubule development
GO:2000378
IDA
Genome Projectnegative regulation of reactive oxygen species metabolic process
GO:2000594
ISS
Genome Projectpositive regulation of metanephric DCT cell differentiation
GO:2000597
ISS
Genome Projectpositive regulation of optic nerve formation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000987
IDA
Genome Projectcore promoter proximal region sequence-specific DNA binding
GO:0003677
IDA
ISS
TAS, IEA
Genome ProjectDNA binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008134
IPI
Genome Projecttranscription factor binding
GO:0016175
ISS
Genome Projectsuperoxide-generating NADPH oxidase activity
GO:0044212
IDA
Genome Projecttranscription regulatory region DNA binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005764
IEA
Genome Projectlysosome
GO:0005815
IDA
Genome Projectmicrotubule organizing center
GO:0032993
ISS
Genome Projectprotein-DNA complex
GO:0034451
IDA
Genome Projectcentriolar satellite
GO:0043234
ISS
Genome Projectprotein complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001523Paired domain
IPR009057Homeodomain-like
IPR011991Winged helix-turn-helix DNA-binding domain
IPR022130Paired-box protein 2 C-terminal

No MapMan annotations defined for this gene.