Gene: ENSG00000073921 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000073921
Transcript Identifier
ENST00000393346
Gene Type
Coding gene
Location
11 : 85959046-86068780 : negative

Family Information

Homologous gene family
HOM03P000708
(78 genes in 29 species)
specific family
Orthologous gene family
ORTHO03P028885
(4 genes in 4 species)
specific family

Descriptions

gene_descr
phosphatidylinositol binding clathrin assembly protein

Identifiers

Type Value
pidENSP00000377015
HGNC15514
UniprotQ13492
UniprotA0A024R5P1

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006897
IEA
Genome Projectendocytosis
GO:0007409
IEA
Genome Projectaxonogenesis
GO:0016188
ISS
IEA
Genome Projectsynaptic vesicle maturation
GO:0030097
IEA
Genome Projecthemopoiesis
GO:0048268
IMP
IEA
Genome Projectclathrin coat assembly
GO:0048813
IEA
Genome Projectdendrite morphogenesis
GO:1902961
ISS
IEA
Genome Projectpositive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902963
ISS
IEA
Genome Projectnegative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:0006461
TAS
Genome Projectprotein complex assembly
GO:0006898
IDA
ISS
Genome Projectreceptor-mediated endocytosis
GO:0008283
IMP
Genome Projectcell proliferation
GO:0010629
IMP
Genome Projectnegative regulation of gene expression
GO:0016192
TAS
Genome Projectvesicle-mediated transport
GO:0016197
IMP
Genome Projectendosomal transport
GO:0030100
IMP
Genome Projectregulation of endocytosis
GO:0031623
IMP
Genome Projectreceptor internalization
GO:0032880
IDA
Genome Projectregulation of protein localization
GO:0035459
IMP
Genome Projectcargo loading into vesicle
GO:0045893
IDA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0048261
IDA
Genome Projectnegative regulation of receptor-mediated endocytosis
GO:0055072
IMP
Genome Projectiron ion homeostasis
GO:0072583
IMP
Genome Projectclathrin-mediated endocytosis
GO:0097459
IMP
Genome Projectiron ion import into cell
GO:1901216
IMP
Genome Projectpositive regulation of neuron death
GO:1902004
IMP
Genome Projectpositive regulation of beta-amyloid formation
GO:1902959
IMP
Genome Projectregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005543
IEA
Genome Projectphospholipid binding
GO:0005545
ISS
IEA
Genome Project1-phosphatidylinositol binding
GO:0030276
IDA, IPI
ISS
IEA
Genome Projectclathrin binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0032050
IDA
Genome Projectclathrin heavy chain binding
GO:0035615
IMP
Genome Projectclathrin adaptor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005622
IEA
Genome Projectintracellular
GO:0030136
IEA
Genome Projectclathrin-coated vesicle
GO:0031982
ISS
IEA
Genome Projectvesicle
GO:0048471
ISS
IEA
Genome Projectperinuclear region of cytoplasm
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005794
IEA
Genome ProjectGolgi apparatus
GO:0005905
IDA
ISS
IEA
Genome Projectcoated pit
GO:0016020
IDA
IEA
Genome Projectmembrane
GO:0031410
IEA
Genome Projectcytoplasmic vesicle
GO:0042734
ISS
Genome Projectpresynaptic membrane
GO:0043025
IDA
Genome Projectneuronal cell body
GO:0043231
IDA
Genome Projectintracellular membrane-bounded organelle
GO:0045211
ISS
Genome Projectpostsynaptic membrane
GO:0097418
IMP
Genome Projectneurofibrillary tangle
GO:0030122
IDA
Genome ProjectAP-2 adaptor complex
GO:0030132
IDA
Genome Projectclathrin coat of coated pit

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR008942ENTH/VHS
IPR011417AP180 N-terminal homology (ANTH) domain
IPR013809ENTH domain
IPR014712Phosphoinositide-binding clathrin adaptor, domain 2
IPR030412Phosphatidylinositol-binding clathrin assembly protein

No MapMan annotations defined for this gene.