Gene: ENSG00000073756 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000073756
Transcript Identifier
ENST00000367468
Gene Type
Coding gene
Location
1 : 186674353-186680290 : negative

Family Information

Homologous gene family
HOM03P019995
(4 genes in 2 species)
specific family

Descriptions

gene_descr
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

Identifiers

Type Value
pidENSP00000356438
HGNC9605
UniprotP35354

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001516
ISS
NAS, IEA
Genome Projectprostaglandin biosynthetic process
GO:0001525
IEA
Genome Projectangiogenesis
GO:0006629
IEA
Genome Projectlipid metabolic process
GO:0006631
IEA
Genome Projectfatty acid metabolic process
GO:0006633
IEA
Genome Projectfatty acid biosynthetic process
GO:0006693
TAS, IEA
Genome Projectprostaglandin metabolic process
GO:0006766
TAS
Genome Projectvitamin metabolic process
GO:0006767
TAS
Genome Projectwater-soluble vitamin metabolic process
GO:0006769
TAS
Genome Projectnicotinamide metabolic process
GO:0006928
TAS
Genome Projectmovement of cell or subcellular component
GO:0006954
IEA
Genome Projectinflammatory response
GO:0006979
IEA
Genome Projectresponse to oxidative stress
GO:0007566
IEA
Genome Projectembryo implantation
GO:0007612
IEA
Genome Projectlearning
GO:0007613
IEA
Genome Projectmemory
GO:0008217
ISS
IEA
Genome Projectregulation of blood pressure
GO:0008284
IEA
Genome Projectpositive regulation of cell proliferation
GO:0008285
IEA
Genome Projectnegative regulation of cell proliferation
GO:0009314
IEA
Genome Projectresponse to radiation
GO:0009750
IEA
Genome Projectresponse to fructose
GO:0010033
IEA
Genome Projectresponse to organic substance
GO:0010042
IEA
Genome Projectresponse to manganese ion
GO:0010226
IEA
Genome Projectresponse to lithium ion
GO:0010243
IEA
Genome Projectresponse to organonitrogen compound
GO:0010575
ISS
IEA
Genome Projectpositive regulation of vascular endothelial growth factor production
GO:0010942
IEA
Genome Projectpositive regulation of cell death
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0019233
IEA
Genome Projectsensory perception of pain
GO:0019369
TAS
Genome Projectarachidonic acid metabolic process
GO:0019371
IDA
TAS, IEA
Genome Projectcyclooxygenase pathway
GO:0019372
TAS
Genome Projectlipoxygenase pathway
GO:0019674
TAS
Genome ProjectNAD metabolic process
GO:0030282
IEA
Genome Projectbone mineralization
GO:0030728
IEA
Genome Projectovulation
GO:0031394
NAS
Genome Projectpositive regulation of prostaglandin biosynthetic process
GO:0031622
ISS
IEA
Genome Projectpositive regulation of fever generation
GO:0031915
IEA
Genome Projectpositive regulation of synaptic plasticity
GO:0032227
IEA
Genome Projectnegative regulation of synaptic transmission, dopaminergic
GO:0032355
IEA
Genome Projectresponse to estradiol
GO:0032496
IEA
Genome Projectresponse to lipopolysaccharide
GO:0033280
IEA
Genome Projectresponse to vitamin D
GO:0034097
IEA
Genome Projectresponse to cytokine
GO:0034612
IEA
Genome Projectresponse to tumor necrosis factor
GO:0034644
IEA
Genome Projectcellular response to UV
GO:0035633
IEA
Genome Projectmaintenance of blood-brain barrier
GO:0042127
IEA
Genome Projectregulation of cell proliferation
GO:0042346
IEA
Genome Projectpositive regulation of NF-kappaB import into nucleus
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042633
IEA
Genome Projecthair cycle
GO:0043065
IEA
Genome Projectpositive regulation of apoptotic process
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0045429
ISS
IEA
Genome Projectpositive regulation of nitric oxide biosynthetic process
GO:0045786
IEA
Genome Projectnegative regulation of cell cycle
GO:0045907
IEA
Genome Projectpositive regulation of vasoconstriction
GO:0045986
IEA
Genome Projectnegative regulation of smooth muscle contraction
GO:0045987
IEA
Genome Projectpositive regulation of smooth muscle contraction
GO:0046697
IEA
Genome Projectdecidualization
GO:0048661
IEA
Genome Projectpositive regulation of smooth muscle cell proliferation
GO:0050727
NAS
Genome Projectregulation of inflammatory response
GO:0050873
IEA
Genome Projectbrown fat cell differentiation
GO:0051384
IEA
Genome Projectresponse to glucocorticoid
GO:0051926
IEA
Genome Projectnegative regulation of calcium ion transport
GO:0051968
IEA
Genome Projectpositive regulation of synaptic transmission, glutamatergic
GO:0055114
IEA
Genome Projectoxidation-reduction process
GO:0070542
IEA
Genome Projectresponse to fatty acid
GO:0071260
IEA
Genome Projectcellular response to mechanical stimulus
GO:0071318
IEA
Genome Projectcellular response to ATP
GO:0071456
IEP
Genome Projectcellular response to hypoxia
GO:0071498
IEA
Genome Projectcellular response to fluid shear stress
GO:0071636
ISS
IEA
Genome Projectpositive regulation of transforming growth factor beta production
GO:0090050
ISS
IEA
Genome Projectpositive regulation of cell migration involved in sprouting angiogenesis
GO:0090271
ISS
IEA
Genome Projectpositive regulation of fibroblast growth factor production
GO:0090336
ISS
IEA
Genome Projectpositive regulation of brown fat cell differentiation
GO:0090362
ISS
IEA
Genome Projectpositive regulation of platelet-derived growth factor production

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004601
NAS, IEA
Genome Projectperoxidase activity
GO:0004666
IDA
IEA
Genome Projectprostaglandin-endoperoxide synthase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008289
IEA
Genome Projectlipid binding
GO:0016491
IEA
Genome Projectoxidoreductase activity
GO:0016702
IEA
Genome Projectoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0019899
IPI
Genome Projectenzyme binding
GO:0020037
ISS
IEA
Genome Projectheme binding
GO:0042803
IEA
Genome Projectprotein homodimerization activity
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0050473
TAS
Genome Projectarachidonate 15-lipoxygenase activity
GO:0051213
IEA
Genome Projectdioxygenase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
ISS
Genome Projectnucleus
GO:0005737
IDA
ISS
Genome Projectcytoplasm
GO:0005783
IDA
IEA
Genome Projectendoplasmic reticulum
GO:0005788
TAS
Genome Projectendoplasmic reticulum lumen
GO:0005789
TAS, IEA
Genome Projectendoplasmic reticulum membrane
GO:0005901
IEA
Genome Projectcaveola
GO:0016020
IEA
Genome Projectmembrane
GO:0031090
IEA
Genome Projectorganelle membrane
GO:0043005
IDA
IEA
Genome Projectneuron projection
GO:0043231
IEA
Genome Projectintracellular membrane-bounded organelle
GO:0043234
IEA
Genome Projectprotein complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000742EGF-like domain
IPR010255Haem peroxidase
IPR019791Haem peroxidase, animal
IPR029576Prostaglandin G/H synthase 2

No MapMan annotations defined for this gene.