Gene: ENSG00000073282 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000073282
Transcript Identifier
ENST00000264731
Gene Type
Coding gene
Location
3 : 189631516-189894502 : positive

Family Information

Homologous gene family
HOM03P014610
(6 genes in 3 species)
specific family

Descriptions

gene_descr
tumor protein p63

Identifiers

Type Value
pidENSP00000264731
HGNC15979
UniprotQ9H3D4

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IBA
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001302
IEA
Genome Projectreplicative cell aging
GO:0001501
IEA
Genome Projectskeletal system development
GO:0001736
IEA
Genome Projectestablishment of planar polarity
GO:0001738
IEA
Genome Projectmorphogenesis of a polarized epithelium
GO:0001942
IEA
Genome Projecthair follicle development
GO:0002053
IEA
Genome Projectpositive regulation of mesenchymal cell proliferation
GO:0002064
IEA
Genome Projectepithelial cell development
GO:0006338
IEA
Genome Projectchromatin remodeling
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006367
TAS
Genome Projecttranscription initiation from RNA polymerase II promoter
GO:0006915
TAS, IEA
Genome Projectapoptotic process
GO:0006974
IDA
Genome Projectcellular response to DNA damage stimulus
GO:0006978
IBA
Genome ProjectDNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007219
IEA
Genome ProjectNotch signaling pathway
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007283
IEA
Genome Projectspermatogenesis
GO:0007389
IEA
Genome Projectpattern specification process
GO:0007499
IEA
Genome Projectectoderm and mesoderm interaction
GO:0007569
IEA
Genome Projectcell aging
GO:0008544
IEA
Genome Projectepidermis development
GO:0009887
IEA
Genome Projectorgan morphogenesis
GO:0009954
IEA
Genome Projectproximal/distal pattern formation
GO:0010165
IBA
Genome Projectresponse to X-ray
GO:0010259
IEA
Genome Projectmulticellular organismal aging
GO:0010332
IBA
Genome Projectresponse to gamma radiation
GO:0010467
TAS
Genome Projectgene expression
GO:0010481
IEA
Genome Projectepidermal cell division
GO:0010482
ISS
IEA
Genome Projectregulation of epidermal cell division
GO:0010838
IEA
Genome Projectpositive regulation of keratinocyte proliferation
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030216
IEA
Genome Projectkeratinocyte differentiation
GO:0030326
IEA
Genome Projectembryonic limb morphogenesis
GO:0030850
IEA
Genome Projectprostate gland development
GO:0030855
IEA
Genome Projectepithelial cell differentiation
GO:0030859
IEA
Genome Projectpolarized epithelial cell differentiation
GO:0031069
IEA
Genome Projecthair follicle morphogenesis
GO:0031571
IBA
Genome Projectmitotic G1 DNA damage checkpoint
GO:0034644
IBA
Genome Projectcellular response to UV
GO:0036342
IEA
Genome Projectpost-anal tail morphogenesis
GO:0042475
IEA
Genome Projectodontogenesis of dentin-containing tooth
GO:0042771
IBA
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043066
IBA
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043281
IEA
Genome Projectregulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043523
IBA
Genome Projectregulation of neuron apoptotic process
GO:0043589
IEA
Genome Projectskin morphogenesis
GO:0043616
IEA
Genome Projectkeratinocyte proliferation
GO:0045617
IEA
Genome Projectnegative regulation of keratinocyte differentiation
GO:0045669
IMP
Genome Projectpositive regulation of osteoblast differentiation
GO:0045747
IDA
Genome Projectpositive regulation of Notch signaling pathway
GO:0045892
IDA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IDA
NAS
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048485
IEA
Genome Projectsympathetic nervous system development
GO:0048646
IEA
Genome Projectanatomical structure formation involved in morphogenesis
GO:0048745
IEA
Genome Projectsmooth muscle tissue development
GO:0048807
IEA
Genome Projectfemale genitalia morphogenesis
GO:0051262
IEA
Genome Projectprotein tetramerization
GO:0051289
IPI
Genome Projectprotein homotetramerization
GO:0051402
IEA
Genome Projectneuron apoptotic process
GO:0060157
IEA
Genome Projecturinary bladder development
GO:0060197
IEA
Genome Projectcloacal septation
GO:0060513
IEA
Genome Projectprostatic bud formation
GO:0060529
IEA
Genome Projectsquamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0061436
ISS
IEA
Genome Projectestablishment of skin barrier
GO:1902808
IMP
Genome Projectpositive regulation of cell cycle G1/S phase transition
GO:2000271
IDA
Genome Projectpositive regulation of fibroblast apoptotic process
GO:2000381
IEA
Genome Projectnegative regulation of mesoderm development
GO:2000773
IMP
Genome Projectnegative regulation of cellular senescence
GO:2001235
IEA
Genome Projectpositive regulation of apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000989
IEA
Genome Projecttranscription factor activity, transcription factor binding
GO:0001077
IEA
Genome Projecttranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0002039
IBA
Genome Projectp53 binding
GO:0003677
NAS, IEA
Genome ProjectDNA binding
GO:0003682
IDA
Genome Projectchromatin binding
GO:0003684
IBA
IEA
Genome Projectdamaged DNA binding
GO:0003690
IBA
IEA
Genome Projectdouble-stranded DNA binding
GO:0003700
IBA
IEA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0019904
IEA
Genome Projectprotein domain specific binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0043565
IBA
IEA
Genome Projectsequence-specific DNA binding
GO:0044212
IEA
Genome Projecttranscription regulatory region DNA binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0050699
IPI
Genome ProjectWW domain binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000790
IDA
Genome Projectnuclear chromatin
GO:0005634
IDA
NAS, IEA
Genome Projectnucleus
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005667
IBA
Genome Projecttranscription factor complex
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005791
IEA
Genome Projectrough endoplasmic reticulum
GO:0005829
IBA
Genome Projectcytosol
GO:0030425
IBA
IEA
Genome Projectdendrite
GO:0043005
IEA
Genome Projectneuron projection
GO:0043234
IEA
Genome Projectprotein complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001660Sterile alpha motif domain
IPR002117p53 tumour suppressor family
IPR008967p53-like transcription factor, DNA-binding
IPR010991p53, tetramerisation domain
IPR011615p53, DNA-binding domain
IPR012346p53/RUNT-type transcription factor, DNA-binding domain
IPR013761Sterile alpha motif/pointed domain
IPR032645Tumour protein p63

No MapMan annotations defined for this gene.