Gene: ENSG00000072110 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000072110
Transcript Identifier
ENST00000538545
Gene Type
Coding gene
Location
14 : 68874859-68979056 : negative

Family Information

Homologous gene family
HOM03P000481
(99 genes in 11 species)
specific family
Orthologous gene family
ORTHO03P006041
(14 genes in 10 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
actinin, alpha 1

Identifiers

Type Value
pidENSP00000439828
HGNC163
UniprotP12814

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002576
TAS
Genome Projectplatelet degranulation
GO:0007015
IMP
Genome Projectactin filament organization
GO:0007596
TAS
Genome Projectblood coagulation
GO:0030168
IMP
TAS
Genome Projectplatelet activation
GO:0030198
TAS
Genome Projectextracellular matrix organization
GO:0030220
IMP
Genome Projectplatelet formation
GO:0034329
TAS
Genome Projectcell junction assembly
GO:0036344
IMP
Genome Projectplatelet morphogenesis
GO:0042981
NAS
Genome Projectregulation of apoptotic process
GO:0048041
IMP
Genome Projectfocal adhesion assembly
GO:0051017
IEA
Genome Projectactin filament bundle assembly
GO:0051271
IMP
Genome Projectnegative regulation of cellular component movement
GO:0051639
IMP
Genome Projectactin filament network formation
GO:0051764
IEA
Genome Projectactin crosslink formation
GO:1903506
IDA
Genome Projectregulation of nucleic acid-templated transcription
GO:0070527
IMP
Genome Projectplatelet aggregation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003725
IDA
Genome Projectdouble-stranded RNA binding
GO:0003779
IEA
Genome Projectactin binding
GO:0005178
IDA, IPI
Genome Projectintegrin binding
GO:0005509
IEA
Genome Projectcalcium ion binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0017166
IDA, IPI
Genome Projectvinculin binding
GO:0030374
IDA
Genome Projectligand-dependent nuclear receptor transcription coactivator activity
GO:0042803
IDA
Genome Projectprotein homodimerization activity
GO:0044325
IPI
Genome Projection channel binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0051015
IDA
IEA
Genome Projectactin filament binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001725
IDA
Genome Projectstress fiber
GO:0001726
IDA
IEA
Genome Projectruffle
GO:0005576
TAS
Genome Projectextracellular region
GO:0005615
IDA
Genome Projectextracellular space
GO:0005622
IDA
Genome Projectintracellular
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005829
TAS
Genome Projectcytosol
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005886
IEA
Genome Projectplasma membrane
GO:0005903
IEA
Genome Projectbrush border
GO:0005911
IDA
Genome Projectcell-cell junction
GO:0005916
IEA
Genome Projectfascia adherens
GO:0005925
IDA, IMP
Genome Projectfocal adhesion
GO:0016020
IEA
Genome Projectmembrane
GO:0030018
IEA
Genome ProjectZ disc
GO:0030054
IEA
Genome Projectcell junction
GO:0031093
TAS
Genome Projectplatelet alpha granule lumen
GO:0031143
TAS
Genome Projectpseudopodium
GO:0042995
IDA
IEA
Genome Projectcell projection
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0005884
IDA
Genome Projectactin filament

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001589Actinin-type actin-binding domain, conserved site
IPR001715Calponin homology domain
IPR002017Spectrin repeat
IPR002048EF-hand domain
IPR011992EF-hand domain pair
IPR014837EF-hand, Ca insensitive
IPR018159Spectrin/alpha-actinin
IPR018247EF-Hand 1, calcium-binding site
IPR026921Alpha-actinin 1

No MapMan annotations defined for this gene.