Gene: ENSG00000071051 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000071051
Transcript Identifier
ENST00000393349
Gene Type
Coding gene
Location
2 : 105855064-105893176 : positive

Family Information

Homologous gene family
HOM03P006490
(13 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P014998
(6 genes in 4 species)
specific family

Descriptions

gene_descr
NCK adaptor protein 2

Identifiers

Type Value
pidENSP00000377018
HGNC7665
UniprotO43639

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001771
IEA
Genome Projectimmunological synapse formation
GO:0006417
IEA
Genome Projectregulation of translation
GO:0007015
IEA
Genome Projectactin filament organization
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007172
NAS
Genome Projectsignal complex assembly
GO:0007173
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007176
TAS
Genome Projectregulation of epidermal growth factor-activated receptor activity
GO:0007411
TAS
Genome Projectaxon guidance
GO:0008285
TAS
Genome Projectnegative regulation of cell proliferation
GO:0016477
IEA
Genome Projectcell migration
GO:0030032
IEA
Genome Projectlamellipodium assembly
GO:0030838
IMP
Genome Projectpositive regulation of actin filament polymerization
GO:0033137
IDA
Genome Projectnegative regulation of peptidyl-serine phosphorylation
GO:0036493
IEA
Genome Projectpositive regulation of translation in response to endoplasmic reticulum stress
GO:0042102
IMP
Genome Projectpositive regulation of T cell proliferation
GO:0042110
NAS
Genome ProjectT cell activation
GO:0045944
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048010
TAS
Genome Projectvascular endothelial growth factor receptor signaling pathway
GO:0048013
TAS, IEA
Genome Projectephrin receptor signaling pathway
GO:0060996
IEA
Genome Projectdendritic spine development
GO:1902237
IEA
Genome Projectpositive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903898
IEA
Genome Projectnegative regulation of PERK-mediated unfolded protein response
GO:1903912
IDA
Genome Projectnegative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:1990441
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005070
NAS
Genome ProjectSH3/SH2 adaptor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008093
NAS
Genome Projectcytoskeletal adaptor activity
GO:0030159
NAS
Genome Projectreceptor signaling complex scaffold activity
GO:0032403
IEA
Genome Projectprotein complex binding
GO:0097110
IEA
Genome Projectscaffold protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
NAS, IEA
Genome Projectcytoplasm
GO:0005783
IDA
IEA
Genome Projectendoplasmic reticulum
GO:0005829
TAS
Genome Projectcytosol
GO:0012506
IEA
Genome Projectvesicle membrane
GO:0045202
IEA
Genome Projectsynapse
GO:0097481
IEA
Genome Projectneuronal postsynaptic density

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000980SH2 domain
IPR001452SH3 domain
IPR017304Cytoplasmic protein NCK

No MapMan annotations defined for this gene.