Gene: ENSG00000070018 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000070018
Transcript Identifier
ENST00000261349
Gene Type
Coding gene
Location
12 : 12121126-12266735 : negative

Family Information

Homologous gene family
HOM03P001101
(58 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P005166
(16 genes in 4 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
low density lipoprotein receptor-related protein 6

Identifiers

Type Value
pidENSP00000261349
HGNC6698
UniprotO75581

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001843
IBA
Genome Projectneural tube closure
GO:0001933
IMP
Genome Projectnegative regulation of protein phosphorylation
GO:0003344
IBA
Genome Projectpericardium morphogenesis
GO:0006469
IMP
Genome Projectnegative regulation of protein kinase activity
GO:0006897
IEA
Genome Projectendocytosis
GO:0007268
IBA
Genome Projectsynaptic transmission
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0009880
IBA
Genome Projectembryonic pattern specification
GO:0014029
IDA
Genome Projectneural crest formation
GO:0014033
IDA
Genome Projectneural crest cell differentiation
GO:0016055
IDA, IMP
IEA
Genome ProjectWnt signaling pathway
GO:0021587
IBA
Genome Projectcerebellum morphogenesis
GO:0021794
IBA
Genome Projectthalamus development
GO:0021987
IBA
Genome Projectcerebral cortex development
GO:0030901
IBA
Genome Projectmidbrain development
GO:0030917
IBA
Genome Projectmidbrain-hindbrain boundary development
GO:0034392
IMP
Genome Projectnegative regulation of smooth muscle cell apoptotic process
GO:0035261
IBA
Genome Projectexternal genitalia morphogenesis
GO:0042475
IBA
Genome Projectodontogenesis of dentin-containing tooth
GO:0044332
IDA
Genome ProjectWnt signaling pathway involved in dorsal/ventral axis specification
GO:0044335
IC
Genome Projectcanonical Wnt signaling pathway involved in neural crest cell differentiation
GO:0044340
IC
Genome Projectcanonical Wnt signaling pathway involved in regulation of cell proliferation
GO:0045787
IMP
Genome Projectpositive regulation of cell cycle
GO:0045893
IMP
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0051091
IDA
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0060021
IBA
Genome Projectpalate development
GO:0060026
IBA
Genome Projectconvergent extension
GO:0060059
IBA
Genome Projectembryonic retina morphogenesis in camera-type eye
GO:0060070
IDA, IMP
Genome Projectcanonical Wnt signaling pathway
GO:0060325
IBA
Genome Projectface morphogenesis
GO:0060535
IBA
Genome Projecttrachea cartilage morphogenesis
GO:0071397
IMP
Genome Projectcellular response to cholesterol
GO:0071901
IDA
Genome Projectnegative regulation of protein serine/threonine kinase activity
GO:0090009
IBA
Genome Projectprimitive streak formation
GO:0090090
TAS
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:0090118
IBA
Genome Projectreceptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
GO:0090244
IBA
Genome ProjectWnt signaling pathway involved in somitogenesis
GO:0090245
IBA
Genome Projectaxis elongation involved in somitogenesis
GO:0090263
IDA
TAS
Genome Projectpositive regulation of canonical Wnt signaling pathway
GO:1901998
IMP
Genome Projecttoxin transport
GO:2000055
IDA
Genome Projectpositive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005041
IDA
Genome Projectlow-density lipoprotein receptor activity
GO:0005102
IPI
Genome Projectreceptor binding
GO:0005109
IPI
Genome Projectfrizzled binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0017147
IPI
Genome ProjectWnt-protein binding
GO:0019210
IMP
Genome Projectkinase inhibitor activity
GO:0019534
IMP
Genome Projecttoxin transporter activity
GO:0034185
IBA
Genome Projectapolipoprotein binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042803
IPI
Genome Projectprotein homodimerization activity
GO:0042813
IBA
Genome ProjectWnt-activated receptor activity
GO:0071936
IDA
Genome Projectcoreceptor activity involved in Wnt signaling pathway

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS
Genome Projectextracellular region
GO:0005783
IEA
Genome Projectendoplasmic reticulum
GO:0005886
IDA
TAS
Genome Projectplasma membrane
GO:0009986
IDA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0031410
IDA
Genome Projectcytoplasmic vesicle
GO:0031901
TAS
Genome Projectearly endosome membrane
GO:0043025
IBA
Genome Projectneuronal cell body
GO:0043235
IBA
Genome Projectreceptor complex
GO:0045202
IBA
Genome Projectsynapse
GO:0005769
IDA
Genome Projectearly endosome
GO:0005794
IDA
Genome ProjectGolgi apparatus
GO:0005901
IDA
Genome Projectcaveola

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000033LDLR class B repeat
IPR000742EGF-like domain
IPR002172Low-density lipoprotein (LDL) receptor class A repeat
IPR011042Six-bladed beta-propeller, TolB-like
IPR017049Low density lipoprotein receptor-related protein 5/6
IPR023415Low-density lipoprotein (LDL) receptor class A, conserved site

No MapMan annotations defined for this gene.