Gene: ENSG00000069869 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000069869
Transcript Identifier
ENST00000508342
Gene Type
Coding gene
Location
15 : 55829897-55916831 : negative

Family Information

Homologous gene family
HOM03P000060
(418 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P003574
(23 genes in 8 species)
specific family

Descriptions

gene_descr
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase

Identifiers

Type Value
pidENSP00000424827
HGNC7727
UniprotP46934

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0002250
IEA
Genome Projectadaptive immune response
GO:0003151
IEA
Genome Projectoutflow tract morphogenesis
GO:0003197
IEA
Genome Projectendocardial cushion development
GO:0006513
IEA
Genome Projectprotein monoubiquitination
GO:0006622
IDA
Genome Projectprotein targeting to lysosome
GO:0007041
IDA
Genome Projectlysosomal transport
GO:0007399
IEA
Genome Projectnervous system development
GO:0007528
IEA
Genome Projectneuromuscular junction development
GO:0010766
IDA
IEA
Genome Projectnegative regulation of sodium ion transport
GO:0010768
IMP
Genome Projectnegative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0014068
IMP
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0016032
IEA
Genome Projectviral process
GO:0016567
IDA
IEA
Genome Projectprotein ubiquitination
GO:0019089
IMP
Genome Projecttransmission of virus
GO:0019221
TAS
Genome Projectcytokine-mediated signaling pathway
GO:0030948
ISS
IEA
Genome Projectnegative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031175
IEP
Genome Projectneuron projection development
GO:0031623
IDA
Genome Projectreceptor internalization
GO:0032801
IDA
Genome Projectreceptor catabolic process
GO:0034644
IMP
Genome Projectcellular response to UV
GO:0034765
IDA
Genome Projectregulation of ion transmembrane transport
GO:0042110
IEA
Genome ProjectT cell activation
GO:0042391
IDA
Genome Projectregulation of membrane potential
GO:0042787
IDA, IMP
Genome Projectprotein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042921
IDA
Genome Projectglucocorticoid receptor signaling pathway
GO:0043162
IMP
Genome Projectubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0044111
IMP
Genome Projectdevelopment involved in symbiotic interaction
GO:0045732
IDA
Genome Projectpositive regulation of protein catabolic process
GO:0046824
IDA
Genome Projectpositive regulation of nucleocytoplasmic transport
GO:0048514
IEA
Genome Projectblood vessel morphogenesis
GO:0048814
ISS
IEA
Genome Projectregulation of dendrite morphogenesis
GO:0050807
IEA
Genome Projectregulation of synapse organization
GO:0050847
IDA
Genome Projectprogesterone receptor signaling pathway
GO:0051592
TAS
Genome Projectresponse to calcium ion
GO:0070534
ISS
Genome Projectprotein K63-linked ubiquitination
GO:1901016
IDA
Genome Projectregulation of potassium ion transmembrane transporter activity
GO:2000650
IDA
Genome Projectnegative regulation of sodium ion transmembrane transporter activity

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004842
IEA
Genome Projectubiquitin-protein transferase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0016874
IEA
Genome Projectligase activity
GO:0019871
IDA
IEA
Genome Projectsodium channel inhibitor activity
GO:0019904
IPI
Genome Projectprotein domain specific binding
GO:0031698
IDA
Genome Projectbeta-2 adrenergic receptor binding
GO:0043130
IDA
Genome Projectubiquitin binding
GO:0050815
ISS
IEA
Genome Projectphosphoserine binding
GO:0050816
ISS
IEA
Genome Projectphosphothreonine binding
GO:0061630
IDA
IEA
Genome Projectubiquitin protein ligase activity
GO:0070063
IPI
Genome ProjectRNA polymerase binding
GO:0070064
IPI, IMP
IEA
Genome Projectproline-rich region binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000151
ISS
IEA
Genome Projectubiquitin ligase complex
GO:0000785
IDA
Genome Projectchromatin
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005794
IDA
Genome ProjectGolgi apparatus
GO:0005829
ISS
TAS, IEA
Genome Projectcytosol
GO:0005886
IDA, IMP
IEA
Genome Projectplasma membrane
GO:0005938
IDA
Genome Projectcell cortex
GO:0016020
IEA
Genome Projectmembrane
GO:0016327
TAS
Genome Projectapicolateral plasma membrane
GO:0048471
IDA
Genome Projectperinuclear region of cytoplasm
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000008C2 domain
IPR000569HECT domain
IPR001202WW domain

No MapMan annotations defined for this gene.