Gene: ENSG00000068024 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000068024
Transcript Identifier
ENST00000345617
Gene Type
Coding gene
Location
2 : 239053097-239352699 : negative

Family Information

Homologous gene family
HOM03P000083
(314 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P012093
(7 genes in 2 species)
specific family

Descriptions

gene_descr
histone deacetylase 4

Identifiers

Type Value
pidENSP00000264606
HGNC14063
UniprotP56524

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IDA, IMP, IGI
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001501
IEA
Genome Projectskeletal system development
GO:0002076
IEA
Genome Projectosteoblast development
GO:0006338
IDA
Genome Projectchromatin remodeling
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006954
TAS
Genome Projectinflammatory response
GO:0007399
TAS
Genome Projectnervous system development
GO:0008284
IMP
Genome Projectpositive regulation of cell proliferation
GO:0008285
IEA
Genome Projectnegative regulation of cell proliferation
GO:0010592
IEA
Genome Projectpositive regulation of lamellipodium assembly
GO:0010832
IMP
Genome Projectnegative regulation of myotube differentiation
GO:0010882
IEA
Genome Projectregulation of cardiac muscle contraction by calcium ion signaling
GO:0014894
ISS
IEA
Genome Projectresponse to denervation involved in regulation of muscle adaptation
GO:0014898
TAS
Genome Projectcardiac muscle hypertrophy in response to stress
GO:0014911
IEA
Genome Projectpositive regulation of smooth muscle cell migration
GO:0016568
IEA
Genome Projectchromatin modification
GO:0016575
IDA, IMP
IEA
Genome Projecthistone deacetylation
GO:0030183
TAS
Genome ProjectB cell differentiation
GO:0033235
IDA
Genome Projectpositive regulation of protein sumoylation
GO:0034983
IDA
Genome Projectpeptidyl-lysine deacetylation
GO:0040029
IMP
Genome Projectregulation of gene expression, epigenetic
GO:0042113
TAS
Genome ProjectB cell activation
GO:0042493
IEA
Genome Projectresponse to drug
GO:0043393
IMP
Genome Projectregulation of protein binding
GO:0043433
IMP
Genome Projectnegative regulation of sequence-specific DNA binding transcription factor activity
GO:0043525
IEA
Genome Projectpositive regulation of neuron apoptotic process
GO:0045668
IEA
Genome Projectnegative regulation of osteoblast differentiation
GO:0045820
ISS
IEA
Genome Projectnegative regulation of glycolytic process
GO:0045892
IDA, IMP
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
ISS
IEA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IMP
ISS
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048661
IEA
Genome Projectpositive regulation of smooth muscle cell proliferation
GO:0048742
IEA
Genome Projectregulation of skeletal muscle fiber development
GO:0051091
IMP
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0051153
IEA
Genome Projectregulation of striated muscle cell differentiation
GO:0070555
IMP
Genome Projectresponse to interleukin-1
GO:0070932
IDA
Genome Projecthistone H3 deacetylation
GO:0070933
IDA
Genome Projecthistone H4 deacetylation
GO:0071260
IEA
Genome Projectcellular response to mechanical stimulus
GO:0071356
IEA
Genome Projectcellular response to tumor necrosis factor
GO:0071374
IEA
Genome Projectcellular response to parathyroid hormone stimulus
GO:1903428
IEA
Genome Projectpositive regulation of reactive oxygen species biosynthetic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001025
IPI
Genome ProjectRNA polymerase III transcription factor binding
GO:0001047
IDA
IEA
Genome Projectcore promoter binding
GO:0003677
IEA
Genome ProjectDNA binding
GO:0003682
IEA
Genome Projectchromatin binding
GO:0003714
IEA
Genome Projecttranscription corepressor activity
GO:0004407
IDA
IEA
Genome Projecthistone deacetylase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008134
IPI
IEA
Genome Projecttranscription factor binding
GO:0008270
IDA
Genome Projectzinc ion binding
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0019901
IEA
Genome Projectprotein kinase binding
GO:0030955
IDA
Genome Projectpotassium ion binding
GO:0032041
IEA
Genome ProjectNAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558
IDA
Genome Projectprotein deacetylase activity
GO:0033613
IPI
Genome Projectactivating transcription factor binding
GO:0042826
IPI
Genome Projecthistone deacetylase binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0070491
IPI
Genome Projectrepressing transcription factor binding
GO:0043565
IDA
Genome Projectsequence-specific DNA binding
GO:0044212
IDA
Genome Projecttranscription regulatory region DNA binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000118
IDA
IEA
Genome Projecthistone deacetylase complex
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
IDA
Genome Projectnucleoplasm
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005829
IEA
Genome Projectcytosol
GO:0017053
IDA
Genome Projecttranscriptional repressor complex
GO:0030017
IEA
Genome Projectsarcomere
GO:0030018
IEA
Genome ProjectZ disc
GO:0031594
IEA
Genome Projectneuromuscular junction
GO:0031672
IEA
Genome ProjectA band
GO:0042641
IEA
Genome Projectactomyosin
GO:0043234
IEA
Genome Projectprotein complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000286Histone deacetylase superfamily
IPR017320Histone deacetylase class II, eukaryotic
IPR023801Histone deacetylase domain
IPR024643Histone deacetylase, glutamine rich N-terminal domain

No MapMan annotations defined for this gene.