Gene: ENSG00000065559 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000065559
Transcript Identifier
ENST00000415385
Gene Type
Coding gene
Location
17 : 12020887-12141260 : positive

Family Information

Homologous gene family
HOM03P000001
(4368 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P019249
(5 genes in 4 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
mitogen-activated protein kinase kinase 4

Identifiers

Type Value
pidENSP00000410402
HGNC6844
UniprotP45985

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000165
IEA
Genome ProjectMAPK cascade
GO:0002224
TAS
Genome Projecttoll-like receptor signaling pathway
GO:0002755
TAS
Genome ProjectMyD88-dependent toll-like receptor signaling pathway
GO:0002756
TAS
Genome ProjectMyD88-independent toll-like receptor signaling pathway
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0006915
IEA
Genome Projectapoptotic process
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007254
TAS
Genome ProjectJNK cascade
GO:0007257
IBA
Genome Projectactivation of JUN kinase activity
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018108
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0034134
TAS
Genome Projecttoll-like receptor 2 signaling pathway
GO:0034138
TAS
Genome Projecttoll-like receptor 3 signaling pathway
GO:0034142
TAS
Genome Projecttoll-like receptor 4 signaling pathway
GO:0034146
TAS
Genome Projecttoll-like receptor 5 signaling pathway
GO:0034162
TAS
Genome Projecttoll-like receptor 9 signaling pathway
GO:0034166
TAS
Genome Projecttoll-like receptor 10 signaling pathway
GO:0035666
TAS
Genome ProjectTRIF-dependent toll-like receptor signaling pathway
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0038123
TAS
Genome Projecttoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124
TAS
Genome Projecttoll-like receptor TLR6:TLR2 signaling pathway
GO:0045087
TAS
Genome Projectinnate immune response
GO:0051403
TAS
Genome Projectstress-activated MAPK cascade
GO:0071260
IEP
Genome Projectcellular response to mechanical stimulus

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
TAS, IEA
Genome Projectprotein kinase activity
GO:0004674
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004713
IEA
Genome Projectprotein tyrosine kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0008545
IBA
Genome ProjectJUN kinase kinase activity
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005622
IBA
Genome Projectintracellular
GO:0005634
IEA
Genome Projectnucleus
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005829
TAS
Genome Projectcytosol

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000719Protein kinase domain
IPR002290Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site

No MapMan annotations defined for this gene.