Gene: ENSG00000055332 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000055332
Transcript Identifier
ENST00000395127
Gene Type
Coding gene
Location
2 : 37107273-37147806 : negative

Family Information

Homologous gene family
HOM03P000001
(4368 genes in 39 species)
specific family
Duplication type
Tandem duplicate

Descriptions

gene_descr
eukaryotic translation initiation factor 2-alpha kinase 2

Identifiers

Type Value
pidENSP00000378559
HGNC9437
UniprotP19525

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000186
IMP
Genome Projectactivation of MAPKK activity
GO:0001819
ISS
IEA
Genome Projectpositive regulation of cytokine production
GO:0002376
IEA
Genome Projectimmune system process
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006412
IEA
Genome Projecttranslation
GO:0006468
IDA
TAS, IEA
Genome Projectprotein phosphorylation
GO:0008285
TAS
Genome Projectnegative regulation of cell proliferation
GO:0009615
IMP
Genome Projectresponse to virus
GO:0010998
TAS
Genome Projectregulation of translational initiation by eIF2 alpha phosphorylation
GO:0016032
IEA
Genome Projectviral process
GO:0016310
IEA
Genome Projectphosphorylation
GO:0017148
IDA, IMP
Genome Projectnegative regulation of translation
GO:0018108
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0019048
TAS
Genome Projectmodulation by virus of host morphology or physiology
GO:0019054
TAS
Genome Projectmodulation by virus of host process
GO:0019058
TAS
Genome Projectviral life cycle
GO:0030683
TAS
Genome Projectevasion or tolerance by virus of host immune response
GO:0030968
IEA
Genome Projectendoplasmic reticulum unfolded protein response
GO:0032722
ISS
IEA
Genome Projectpositive regulation of chemokine production
GO:0032874
ISS
IEA
Genome Projectpositive regulation of stress-activated MAPK cascade
GO:0033689
IMP
Genome Projectnegative regulation of osteoblast proliferation
GO:0034047
TAS
Genome Projectregulation of protein phosphatase type 2A activity
GO:0035455
IDA
Genome Projectresponse to interferon-alpha
GO:0043066
IEA
Genome Projectnegative regulation of apoptotic process
GO:0045071
IMP
Genome Projectnegative regulation of viral genome replication
GO:0045087
IEA
Genome Projectinnate immune response
GO:0046777
IDA, IMP
Genome Projectprotein autophosphorylation
GO:0051092
IDA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051607
IEA
Genome Projectdefense response to virus
GO:1900225
ISS
IEA
Genome Projectregulation of NLRP3 inflammasome complex assembly
GO:1901224
ISS
IEA
Genome Projectpositive regulation of NIK/NF-kappaB signaling
GO:1901532
ISS
IEA
Genome Projectregulation of hematopoietic progenitor cell differentiation
GO:1902033
ISS
IEA
Genome Projectregulation of hematopoietic stem cell proliferation
GO:1902036
ISS
IEA
Genome Projectregulation of hematopoietic stem cell differentiation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0003723
IEA
Genome ProjectRNA binding
GO:0003725
IDA
TAS
Genome Projectdouble-stranded RNA binding
GO:0004672
IDA, IMP
IEA
Genome Projectprotein kinase activity
GO:0004674
TAS, IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004694
TAS
Genome Projecteukaryotic translation initiation factor 2alpha kinase activity
GO:0004713
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004715
IEA
Genome Projectnon-membrane spanning protein tyrosine kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0008601
TAS
Genome Projectprotein phosphatase type 2A regulator activity
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0044822
IDA
Genome Projectpoly(A) RNA binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IEA
Genome Projectnucleus
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005829
TAS
Genome Projectcytosol
GO:0005840
TAS
Genome Projectribosome
GO:0016020
IDA
Genome Projectmembrane
GO:0048471
IDA
IEA
Genome Projectperinuclear region of cytoplasm

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR014720Double-stranded RNA-binding domain
IPR017441Protein kinase, ATP binding site

No MapMan annotations defined for this gene.