Gene: ENSG00000049759 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000049759
Transcript Identifier
ENST00000400345
Gene Type
Coding gene
Location
18 : 58044661-58396269 : positive

Family Information

Homologous gene family
HOM03P000060
(418 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P003574
(23 genes in 8 species)
specific family

Descriptions

gene_descr
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase

Identifiers

Type Value
pidENSP00000383199
HGNC7728
UniprotQ96PU5

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
TAS
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0003085
IEA
Genome Projectnegative regulation of systemic arterial blood pressure
GO:0003254
IDA
Genome Projectregulation of membrane depolarization
GO:0006351
TAS
Genome Projecttranscription, DNA-templated
GO:0006367
TAS
Genome Projecttranscription initiation from RNA polymerase II promoter
GO:0006814
NAS
Genome Projectsodium ion transport
GO:0006883
NAS
Genome Projectcellular sodium ion homeostasis
GO:0007179
TAS
Genome Projecttransforming growth factor beta receptor signaling pathway
GO:0007588
NAS
Genome Projectexcretion
GO:0009651
IEA
Genome Projectresponse to salt stress
GO:0010038
IDA
Genome Projectresponse to metal ion
GO:0010467
TAS
Genome Projectgene expression
GO:0010765
IEA
Genome Projectpositive regulation of sodium ion transport
GO:0016032
TAS, IEA
Genome Projectviral process
GO:0016567
IDA
NAS, IEA
Genome Projectprotein ubiquitination
GO:0019058
TAS
Genome Projectviral life cycle
GO:0030104
NAS
Genome Projectwater homeostasis
GO:0030512
TAS
Genome Projectnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0034220
TAS
Genome Projection transmembrane transport
GO:0034765
IDA
Genome Projectregulation of ion transmembrane transport
GO:0042176
NAS
Genome Projectregulation of protein catabolic process
GO:0042391
IDA
Genome Projectregulation of membrane potential
GO:0042787
IDA
Genome Projectprotein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161
IDA
Genome Projectproteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043162
IEA
Genome Projectubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0045807
NAS
Genome Projectpositive regulation of endocytosis
GO:0055085
TAS
Genome Projecttransmembrane transport
GO:0060306
IDA
Genome Projectregulation of membrane repolarization
GO:0070936
IDA
Genome Projectprotein K48-linked ubiquitination
GO:0086005
ISS
Genome Projectventricular cardiac muscle cell action potential
GO:1901016
IDA
Genome Projectregulation of potassium ion transmembrane transporter activity
GO:1901017
IDA
Genome Projectnegative regulation of potassium ion transmembrane transporter activity
GO:1901380
IDA
Genome Projectnegative regulation of potassium ion transmembrane transport
GO:1902306
IDA
Genome Projectnegative regulation of sodium ion transmembrane transport
GO:1903861
IDA
Genome Projectpositive regulation of dendrite extension
GO:2000009
IDA
Genome Projectnegative regulation of protein localization to cell surface
GO:2000650
IDA
Genome Projectnegative regulation of sodium ion transmembrane transporter activity
GO:2000810
IEA
Genome Projectregulation of bicellular tight junction assembly
GO:2001259
IEA
Genome Projectpositive regulation of cation channel activity
GO:2001288
ISS
Genome Projectpositive regulation of caveolin-mediated endocytosis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004842
IBA
TAS, NAS, IEA
Genome Projectubiquitin-protein transferase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0015459
IDA
Genome Projectpotassium channel regulator activity
GO:0016874
IEA
Genome Projectligase activity
GO:0017080
IDA
Genome Projectsodium channel regulator activity
GO:0019870
IDA
Genome Projectpotassium channel inhibitor activity
GO:0019871
IDA
Genome Projectsodium channel inhibitor activity
GO:0044325
IPI
Genome Projection channel binding
GO:0061630
IEA
Genome Projectubiquitin protein ligase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005622
IC
Genome Projectintracellular
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005737
IBA
IEA
Genome Projectcytoplasm
GO:0005829
TAS
Genome Projectcytosol
GO:0070062
IDA
Genome Projectextracellular exosome
GO:0005886
IDA
Genome Projectplasma membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000008C2 domain
IPR000569HECT domain
IPR001202WW domain

No MapMan annotations defined for this gene.