Gene: ENSG00000044115 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000044115
Transcript Identifier
ENST00000302763
Gene Type
Coding gene
Location
5 : 138781925-138934089 : positive

Family Information

Homologous gene family
HOM03P009424
(9 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P015450
(6 genes in 4 species)
specific family

Descriptions

gene_descr
catenin (cadherin-associated protein), alpha 1, 102kDa

Identifiers

Type Value
pidENSP00000304669
HGNC2509
UniprotP35221

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001541
IEA
Genome Projectovarian follicle development
GO:0007015
IEA
Genome Projectactin filament organization
GO:0007155
NAS, IEA
Genome Projectcell adhesion
GO:0007163
IEA
Genome Projectestablishment or maintenance of cell polarity
GO:0007264
TAS
Genome Projectsmall GTPase mediated signal transduction
GO:0007406
IEA
Genome Projectnegative regulation of neuroblast proliferation
GO:0007568
IEA
Genome Projectaging
GO:0008584
IEA
Genome Projectmale gonad development
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0016264
IEA
Genome Projectgap junction assembly
GO:0031103
IEA
Genome Projectaxon regeneration
GO:0034329
TAS
Genome Projectcell junction assembly
GO:0034332
TAS
Genome Projectadherens junction organization
GO:0034613
IEA
Genome Projectcellular protein localization
GO:0042127
IEA
Genome Projectregulation of cell proliferation
GO:0042475
IEA
Genome Projectodontogenesis of dentin-containing tooth
GO:0042692
TAS
Genome Projectmuscle cell differentiation
GO:0043066
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043297
NAS, IEA
Genome Projectapical junction assembly
GO:0043627
IEA
Genome Projectresponse to estrogen
GO:0045216
TAS
Genome Projectcell-cell junction organization
GO:0045880
IEA
Genome Projectpositive regulation of smoothened signaling pathway
GO:0048010
TAS
Genome Projectvascular endothelial growth factor receptor signaling pathway
GO:0051149
TAS
Genome Projectpositive regulation of muscle cell differentiation
GO:0051291
IEA
Genome Projectprotein heterooligomerization
GO:0071681
IDA
Genome Projectcellular response to indole-3-methanol
GO:0090136
IEA
Genome Projectepithelial cell-cell adhesion
GO:2000146
IEA
Genome Projectnegative regulation of cell motility
GO:2001045
IEA
Genome Projectnegative regulation of integrin-mediated signaling pathway
GO:2001240
IEA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001241
IEA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005198
IEA
Genome Projectstructural molecule activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008013
IPI
IEA
Genome Projectbeta-catenin binding
GO:0017166
IPI
Genome Projectvinculin binding
GO:0044822
IDA
Genome Projectpoly(A) RNA binding
GO:0045295
IPI
Genome Projectgamma-catenin binding
GO:0045296
IPI
IEA
Genome Projectcadherin binding
GO:0051015
IEA
Genome Projectactin filament binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001669
IEA
Genome Projectacrosomal vesicle
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005829
TAS, IEA
Genome Projectcytosol
GO:0005856
IEA
Genome Projectcytoskeleton
GO:0005886
TAS, IEA
Genome Projectplasma membrane
GO:0005911
IDA
IEA
Genome Projectcell-cell junction
GO:0005912
IEA
Genome Projectadherens junction
GO:0005913
IEA
Genome Projectcell-cell adherens junction
GO:0005915
IEA
Genome Projectzonula adherens
GO:0005925
IDA
Genome Projectfocal adhesion
GO:0014704
IEA
Genome Projectintercalated disc
GO:0015629
IEA
Genome Projectactin cytoskeleton
GO:0016020
IEA
Genome Projectmembrane
GO:0016342
IDA
Genome Projectcatenin complex
GO:0030027
IEA
Genome Projectlamellipodium
GO:0030054
IEA
Genome Projectcell junction

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000633Vinculin, conserved site
IPR001033Alpha-catenin
IPR006077Vinculin/alpha-catenin
IPR030047Alpha E-catenin

No MapMan annotations defined for this gene.