Gene: ENSG00000036257 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000036257
Transcript Identifier
ENST00000264414
Gene Type
Coding gene
Location
2 : 224474245-224585009 : negative

Family Information

Homologous gene family
HOM03P000158
(196 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P000688
(45 genes in 39 species)
specific family

Descriptions

gene_descr
cullin 3

Identifiers

Type Value
pidENSP00000264414
HGNC2553
UniprotQ13618
UniprotA0A024R475

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0000278
IEA
Genome Projectmitotic cell cycle
GO:0000902
IEA
Genome Projectcell morphogenesis
GO:0001701
IEA
Genome Projectin utero embryonic development
GO:0001831
IEA
Genome Projecttrophectodermal cellular morphogenesis
GO:0006357
IEA
Genome Projectregulation of transcription from RNA polymerase II promoter
GO:0006511
IEA
Genome Projectubiquitin-dependent protein catabolic process
GO:0007229
ISS
IEA
Genome Projectintegrin-mediated signaling pathway
GO:0007369
IEA
Genome Projectgastrulation
GO:0016055
IEA
Genome ProjectWnt signaling pathway
GO:0017145
ISS
IEA
Genome Projectstem cell division
GO:0040016
ISS
IEA
Genome Projectembryonic cleavage
GO:0044346
IEA
Genome Projectfibroblast apoptotic process
GO:0072576
IEA
Genome Projectliver morphogenesis
GO:0000082
TAS
Genome ProjectG1/S transition of mitotic cell cycle
GO:0000209
IDA
Genome Projectprotein polyubiquitination
GO:0006513
IDA
Genome Projectprotein monoubiquitination
GO:0006810
IEA
Genome Projecttransport
GO:0006888
IDA
Genome ProjectER to Golgi vesicle-mediated transport
GO:0007050
TAS
Genome Projectcell cycle arrest
GO:0007080
IMP
Genome Projectmitotic metaphase plate congression
GO:0008054
IDA
Genome Projectnegative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation
GO:0008284
TAS
Genome Projectpositive regulation of cell proliferation
GO:0016192
IEA
Genome Projectvesicle-mediated transport
GO:0016477
IMP
Genome Projectcell migration
GO:0016567
IDA
IEA
Genome Projectprotein ubiquitination
GO:0032467
IMP
Genome Projectpositive regulation of cytokinesis
GO:0035024
IMP
Genome Projectnegative regulation of Rho protein signal transduction
GO:0042787
IBA
Genome Projectprotein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043149
IMP
Genome Projectstress fiber assembly
GO:0043161
IDA
Genome Projectproteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045842
IMP
Genome Projectpositive regulation of mitotic metaphase/anaphase transition
GO:0048208
IMP
Genome ProjectCOPII vesicle coating
GO:0090090
TAS
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:0097193
TAS
Genome Projectintrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0030332
IEA
Genome Projectcyclin binding
GO:0031625
IEA
Genome Projectubiquitin protein ligase binding
GO:0042803
IEA
Genome Projectprotein homodimerization activity
GO:0046982
IEA
Genome Projectprotein heterodimerization activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0031208
IDA
Genome ProjectPOZ domain binding
GO:0004842
IDA
Genome Projectubiquitin-protein transferase activity
GO:0061630
IBA
Genome Projectubiquitin protein ligase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IEA
Genome Projectnucleus
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005794
IEA
Genome ProjectGolgi apparatus
GO:0031461
IEA
Genome Projectcullin-RING ubiquitin ligase complex
GO:0000139
IMP
Genome ProjectGolgi membrane
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005827
IDA
Genome Projectpolar microtubule
GO:0005829
TAS
Genome Projectcytosol
GO:0016020
IDA
Genome Projectmembrane
GO:0031463
IDA
Genome ProjectCul3-RING ubiquitin ligase complex
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001373Cullin, N-terminal
IPR011991Winged helix-turn-helix DNA-binding domain
IPR016157Cullin, conserved site
IPR016158Cullin homology
IPR016159Cullin repeat-like-containing domain
IPR019559Cullin protein, neddylation domain

No MapMan annotations defined for this gene.