Gene: ENSG00000030110 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000030110
Transcript Identifier
ENST00000374467
Gene Type
Coding gene
Location
6 : 33573803-33577604 : negative

Family Information

Homologous gene family
HOM03P011025
(7 genes in 3 species)
specific family

Descriptions

gene_descr
BCL2-antagonist/killer 1

Identifiers

Type Value
pidENSP00000363591
HGNC949
UniprotQ16611

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001776
IEA
Genome Projectleukocyte homeostasis
GO:0001782
IEA
Genome ProjectB cell homeostasis
GO:0001783
IEA
Genome ProjectB cell apoptotic process
GO:0001836
IDA, IGI
Genome Projectrelease of cytochrome c from mitochondria
GO:0001974
IEA
Genome Projectblood vessel remodeling
GO:0002262
IEA
Genome Projectmyeloid cell homeostasis
GO:0002352
IEA
Genome ProjectB cell negative selection
GO:0006915
TAS, IEA
Genome Projectapoptotic process
GO:0006919
IEA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006987
TAS
Genome Projectactivation of signaling protein activity involved in unfolded protein response
GO:0007420
IEA
Genome Projectbrain development
GO:0007568
IEA
Genome Projectaging
GO:0008053
IEA
Genome Projectmitochondrial fusion
GO:0008283
IEA
Genome Projectcell proliferation
GO:0008285
IEA
Genome Projectnegative regulation of cell proliferation
GO:0008630
IBA
IEA
Genome Projectintrinsic apoptotic signaling pathway in response to DNA damage
GO:0008635
IEA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0009620
IEA
Genome Projectresponse to fungus
GO:0010046
IEA
Genome Projectresponse to mycotoxin
GO:0010225
IEA
Genome Projectresponse to UV-C
GO:0010248
IDA
Genome Projectestablishment or maintenance of transmembrane electrochemical gradient
GO:0010332
IEA
Genome Projectresponse to gamma radiation
GO:0010524
IEA
Genome Projectpositive regulation of calcium ion transport into cytosol
GO:0010629
IEA
Genome Projectnegative regulation of gene expression
GO:0012501
TAS
Genome Projectprogrammed cell death
GO:0014070
IEA
Genome Projectresponse to organic cyclic compound
GO:0019835
IMP
Genome Projectcytolysis
GO:0031018
IEA
Genome Projectendocrine pancreas development
GO:0031100
IEA
Genome Projectorgan regeneration
GO:0032469
TAS
Genome Projectendoplasmic reticulum calcium ion homeostasis
GO:0032471
IEA
Genome Projectnegative regulation of endoplasmic reticulum calcium ion concentration
GO:0033137
IEA
Genome Projectnegative regulation of peptidyl-serine phosphorylation
GO:0034644
IMP
ISS
Genome Projectcellular response to UV
GO:0035108
IEA
Genome Projectlimb morphogenesis
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042542
IEA
Genome Projectresponse to hydrogen peroxide
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0043065
IMP
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043496
IDA
Genome Projectregulation of protein homodimerization activity
GO:0043497
IDA
Genome Projectregulation of protein heterodimerization activity
GO:0044346
IEA
Genome Projectfibroblast apoptotic process
GO:0045471
IEA
Genome Projectresponse to ethanol
GO:0045862
IDA
Genome Projectpositive regulation of proteolysis
GO:0046902
IDA
Genome Projectregulation of mitochondrial membrane permeability
GO:0048597
IEA
Genome Projectpost-embryonic camera-type eye morphogenesis
GO:0048872
IEA
Genome Projecthomeostasis of number of cells
GO:0051726
IEA
Genome Projectregulation of cell cycle
GO:0051881
IDA
Genome Projectregulation of mitochondrial membrane potential
GO:0060068
IEA
Genome Projectvagina development
GO:0070059
TAS, IEA
Genome Projectintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070242
IEA
Genome Projectthymocyte apoptotic process
GO:0071260
IEP
Genome Projectcellular response to mechanical stimulus
GO:0090200
IEA
Genome Projectpositive regulation of release of cytochrome c from mitochondria
GO:0097190
IMP
Genome Projectapoptotic signaling pathway
GO:0097192
IBA
IEA
Genome Projectextrinsic apoptotic signaling pathway in absence of ligand
GO:0097193
TAS
Genome Projectintrinsic apoptotic signaling pathway
GO:0097202
IDA
Genome Projectactivation of cysteine-type endopeptidase activity
GO:1900103
IMP
Genome Projectpositive regulation of endoplasmic reticulum unfolded protein response
GO:1901030
TAS
Genome Projectpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902262
IEA
Genome Projectapoptotic process involved in patterning of blood vessels
GO:1903896
TAS
Genome Projectpositive regulation of IRE1-mediated unfolded protein response

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005515
IPI
Genome Projectprotein binding
GO:0031072
IEA
Genome Projectheat shock protein binding
GO:0042802
IPI
Genome Projectidentical protein binding
GO:0042803
IBA
IEA
Genome Projectprotein homodimerization activity
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0046982
IPI
IEA
Genome Projectprotein heterodimerization activity
GO:0051087
IEA
Genome Projectchaperone binding
GO:0051400
IEA
Genome ProjectBH domain binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005622
IEA
Genome Projectintracellular
GO:0005739
IDA
IEA
Genome Projectmitochondrion
GO:0005741
IBA
TAS
Genome Projectmitochondrial outer membrane
GO:0005783
IEA
Genome Projectendoplasmic reticulum
GO:0005829
IEA
Genome Projectcytosol
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0031307
ISS
IEA
Genome Projectintegral component of mitochondrial outer membrane
GO:0031966
IEA
Genome Projectmitochondrial membrane
GO:0046930
IDA
Genome Projectpore complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR002475Bcl2-like
IPR020717Apoptosis regulator, Bcl-2, BH1 motif, conserved site
IPR020726Apoptosis regulator, Bcl-2, BH2 motif, conserved site
IPR020728Apoptosis regulator, Bcl-2, BH3 motif, conserved site
IPR026298Blc2 family
IPR026308Apoptosis regulator BAK

No MapMan annotations defined for this gene.