Gene: ENSG00000026103 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000026103
Transcript Identifier
ENST00000355740
Gene Type
Coding gene
Location
10 : 88990877-89014450 : positive

Family Information

Homologous gene family
HOM03P025700
(3 genes in 2 species)
specific family

Descriptions

gene_descr
Fas cell surface death receptor

Identifiers

Type Value
pidENSP00000347979
HGNC11920
UniprotP25445

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002377
IEA
Genome Projectimmunoglobulin production
GO:0003014
IEA
Genome Projectrenal system process
GO:0006461
TAS
Genome Projectprotein complex assembly
GO:0006915
IDA
TAS, IEA
Genome Projectapoptotic process
GO:0006919
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006924
IEA
Genome Projectactivation-induced cell death of T cells
GO:0006925
IEA
Genome Projectinflammatory cell apoptotic process
GO:0006927
IEA
Genome Projecttransformed cell apoptotic process
GO:0006955
IEA
Genome Projectimmune response
GO:0007165
TAS, IEA
Genome Projectsignal transduction
GO:0007166
TAS
Genome Projectcell surface receptor signaling pathway
GO:0007623
IEA
Genome Projectcircadian rhythm
GO:0008625
IEA
Genome Projectextrinsic apoptotic signaling pathway via death domain receptors
GO:0009636
IEA
Genome Projectresponse to toxic substance
GO:0010467
IEA
Genome Projectgene expression
GO:0010939
TAS
Genome Projectregulation of necrotic cell death
GO:0012501
TAS
Genome Projectprogrammed cell death
GO:0019724
IEA
Genome ProjectB cell mediated immunity
GO:0032464
IEA
Genome Projectpositive regulation of protein homooligomerization
GO:0042981
NAS
Genome Projectregulation of apoptotic process
GO:0043029
IEA
Genome ProjectT cell homeostasis
GO:0043065
IDA, IMP
Genome Projectpositive regulation of apoptotic process
GO:0043066
TAS, IEA
Genome Projectnegative regulation of apoptotic process
GO:0043154
TAS
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045060
IEA
Genome Projectnegative thymic T cell selection
GO:0045619
IEA
Genome Projectregulation of lymphocyte differentiation
GO:0045637
IEA
Genome Projectregulation of myeloid cell differentiation
GO:0048536
IEA
Genome Projectspleen development
GO:0050869
IEA
Genome Projectnegative regulation of B cell activation
GO:0051260
IEA
Genome Projectprotein homooligomerization
GO:0051384
IEA
Genome Projectresponse to glucocorticoid
GO:0051402
IEA
Genome Projectneuron apoptotic process
GO:0070266
TAS
Genome Projectnecroptotic process
GO:0071260
IEP
Genome Projectcellular response to mechanical stimulus
GO:0071285
IEA
Genome Projectcellular response to lithium ion
GO:0071455
IMP
Genome Projectcellular response to hyperoxia
GO:0097049
IEA
Genome Projectmotor neuron apoptotic process
GO:0097190
TAS, IEA
Genome Projectapoptotic signaling pathway
GO:0097191
IMP
TAS
Genome Projectextrinsic apoptotic signaling pathway
GO:0097192
IEA
Genome Projectextrinsic apoptotic signaling pathway in absence of ligand
GO:0097284
IEA
Genome Projecthepatocyte apoptotic process
GO:0097296
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097300
TAS
Genome Projectprogrammed necrotic cell death
GO:0097527
IMP
Genome Projectnecroptotic signaling pathway
GO:1902041
TAS
Genome Projectregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001241
IEA
Genome Projectpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004871
TAS
Genome Projectsignal transducer activity
GO:0004872
TAS, NAS
Genome Projectreceptor activity
GO:0004888
IEA
Genome Projecttransmembrane signaling receptor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0019900
IPI
Genome Projectkinase binding
GO:0042802
IPI
Genome Projectidentical protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005634
IDA
Genome Projectnucleus
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005829
NAS
Genome Projectcytosol
GO:0005886
IDA, IMP
TAS, IEA
Genome Projectplasma membrane
GO:0009897
IEA
Genome Projectexternal side of plasma membrane
GO:0009986
IDA
Genome Projectcell surface
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0031264
IDA
Genome Projectdeath-inducing signaling complex
GO:0031265
IDA
Genome ProjectCD95 death-inducing signaling complex
GO:0045121
IDA
Genome Projectmembrane raft
GO:0070062
IDA
Genome Projectextracellular exosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000488Death domain
IPR001368TNFR/NGFR cysteine-rich region
IPR008063Fas receptor
IPR011029Death-like domain

No MapMan annotations defined for this gene.