Gene: ENSG00000023909 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000023909
Transcript Identifier
ENST00000370238
Gene Type
Coding gene
Location
1 : 93888990-93909163 : negative

Family Information

Homologous gene family
HOM03P017498
(5 genes in 5 species)
specific family

Descriptions

gene_descr
glutamate-cysteine ligase, modifier subunit

Identifiers

Type Value
pidENSP00000359258
HGNC4312
UniprotP48507

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000096
TAS
Genome Projectsulfur amino acid metabolic process
GO:0006534
IEA
Genome Projectcysteine metabolic process
GO:0006536
IDA
Genome Projectglutamate metabolic process
GO:0006749
IEA
Genome Projectglutathione metabolic process
GO:0006750
IDA, IMP
TAS, IEA
Genome Projectglutathione biosynthetic process
GO:0006805
TAS
Genome Projectxenobiotic metabolic process
GO:0006979
IDA
Genome Projectresponse to oxidative stress
GO:0008637
IEA
Genome Projectapoptotic mitochondrial changes
GO:0034641
TAS
Genome Projectcellular nitrogen compound metabolic process
GO:0035229
IBA
IEA
Genome Projectpositive regulation of glutamate-cysteine ligase activity
GO:0042493
IDA
Genome Projectresponse to drug
GO:0043524
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0050880
IMP
Genome Projectregulation of blood vessel size
GO:0051409
IEA
Genome Projectresponse to nitrosative stress
GO:0051900
IEA
Genome Projectregulation of mitochondrial depolarization
GO:1901687
TAS
Genome Projectglutathione derivative biosynthetic process
GO:2001237
IEA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004357
IDA, IMP
IEA
Genome Projectglutamate-cysteine ligase activity
GO:0030234
IBA
Genome Projectenzyme regulator activity
GO:0035226
IPI
Genome Projectglutamate-cysteine ligase catalytic subunit binding
GO:0046982
IEA
Genome Projectprotein heterodimerization activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005829
TAS, NAS
Genome Projectcytosol
GO:0017109
IBA
IEA
Genome Projectglutamate-cysteine ligase complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR023210NADP-dependent oxidoreductase domain

No MapMan annotations defined for this gene.