Gene: ENSG00000020922 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000020922
Transcript Identifier
ENST00000407439
Gene Type
Coding gene
Location
11 : 94420125-94492670 : negative

Family Information

Homologous gene family
HOM03P002003
(42 genes in 39 species)
specific family

Descriptions

gene_descr
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)

Identifiers

Type Value
pidENSP00000385614
HGNC7230
UniprotP49959

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000019
TAS
Genome Projectregulation of mitotic recombination
GO:0000724
TAS
Genome Projectdouble-strand break repair via homologous recombination
GO:0006259
IEA
Genome ProjectDNA metabolic process
GO:0006281
TAS, IEA
Genome ProjectDNA repair
GO:0006284
IBA
Genome Projectbase-excision repair
GO:0006302
TAS, IEA
Genome Projectdouble-strand break repair
GO:0006303
IDA
TAS
Genome Projectdouble-strand break repair via nonhomologous end joining
GO:0006310
TAS
Genome ProjectDNA recombination
GO:0006974
IDA
IEA
Genome Projectcellular response to DNA damage stimulus
GO:0007004
TAS
Genome Projecttelomere maintenance via telomerase
GO:0007062
IMP
Genome Projectsister chromatid cohesion
GO:0007095
IEA
Genome Projectmitotic G2 DNA damage checkpoint
GO:0007129
IEA
Genome Projectsynapsis
GO:0007131
TAS
Genome Projectreciprocal meiotic recombination
GO:0007507
IEA
Genome Projectheart development
GO:0008283
IEA
Genome Projectcell proliferation
GO:0016032
IEA
Genome Projectviral process
GO:0031573
IBA
IEA
Genome Projectintra-S DNA damage checkpoint
GO:0031954
IDA
Genome Projectpositive regulation of protein autophosphorylation
GO:0032481
TAS
Genome Projectpositive regulation of type I interferon production
GO:0032508
IMP
Genome ProjectDNA duplex unwinding
GO:0032876
IMP
Genome Projectnegative regulation of DNA endoreduplication
GO:0033674
IDA
Genome Projectpositive regulation of kinase activity
GO:0045087
TAS
Genome Projectinnate immune response
GO:0046597
IEA
Genome Projectnegative regulation of viral entry into host cell
GO:0051276
IEA
Genome Projectchromosome organization
GO:0051321
IEA
Genome Projectmeiotic cell cycle
GO:0090305
IDA
TAS, IEA
Genome Projectnucleic acid phosphodiester bond hydrolysis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000014
IDA
TAS
Genome Projectsingle-stranded DNA endodeoxyribonuclease activity
GO:0003690
TAS
Genome Projectdouble-stranded DNA binding
GO:0004518
TAS, IEA
Genome Projectnuclease activity
GO:0004519
IEA
Genome Projectendonuclease activity
GO:0004520
IDA
TAS
Genome Projectendodeoxyribonuclease activity
GO:0004527
IEA
Genome Projectexonuclease activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008022
IPI
Genome Projectprotein C-terminus binding
GO:0008408
IDA
TAS
Genome Project3'-5' exonuclease activity
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0030145
IEA
Genome Projectmanganese ion binding
GO:0003677
IDA
Genome ProjectDNA binding
GO:0004003
IMP
Genome ProjectATP-dependent DNA helicase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000784
IDA
Genome Projectnuclear chromosome, telomeric region
GO:0000785
IBA
Genome Projectchromatin
GO:0000790
IEA
Genome Projectnuclear chromatin
GO:0000794
IEA
Genome Projectcondensed nuclear chromosome
GO:0005634
TAS, IEA
Genome Projectnucleus
GO:0005654
IDA
TAS, IEA
Genome Projectnucleoplasm
GO:0005829
TAS
Genome Projectcytosol
GO:0030870
IDA
NAS
Genome ProjectMre11 complex
GO:0035861
IDA
Genome Projectsite of double-strand break
GO:0048471
IEA
Genome Projectperinuclear region of cytoplasm
GO:0000781
IDA
Genome Projectchromosome, telomeric region

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003701DNA double-strand break repair protein Mre11
IPR004843Calcineurin-like phosphoesterase domain, apaH type
IPR007281Mre11, DNA-binding
IPR029052Metallo-dependent phosphatase-like

No MapMan annotations defined for this gene.