Gene: ENSG00000017427 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000017427
Transcript Identifier
ENST00000307046
Gene Type
Coding gene
Location
12 : 102417818-102480381 : negative

Family Information

Homologous gene family
HOM03P037087
(2 genes in 2 species)
specific family

Descriptions

gene_descr
insulin-like growth factor 1 (somatomedin C)

Identifiers

Type Value
pidENSP00000302665
HGNC5464
UniprotP05019

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001501
TAS
Genome Projectskeletal system development
GO:0001775
IDA
Genome Projectcell activation
GO:0001932
IEA
Genome Projectregulation of protein phosphorylation
GO:0001974
IEA
Genome Projectblood vessel remodeling
GO:0002576
TAS
Genome Projectplatelet degranulation
GO:0006260
TAS
Genome ProjectDNA replication
GO:0006928
TAS
Genome Projectmovement of cell or subcellular component
GO:0007165
TAS
Genome Projectsignal transduction
GO:0007265
TAS
Genome ProjectRas protein signal transduction
GO:0007399
IEA
Genome Projectnervous system development
GO:0007517
TAS
Genome Projectmuscle organ development
GO:0007596
TAS
Genome Projectblood coagulation
GO:0008283
IMP
Genome Projectcell proliferation
GO:0008284
IDA
Genome Projectpositive regulation of cell proliferation
GO:0008285
IEA
Genome Projectnegative regulation of cell proliferation
GO:0009408
IDA
Genome Projectresponse to heat
GO:0009441
TAS
Genome Projectglycolate metabolic process
GO:0010001
IEA
Genome Projectglial cell differentiation
GO:0010468
IMP
Genome Projectregulation of gene expression
GO:0010560
IMP
Genome Projectpositive regulation of glycoprotein biosynthetic process
GO:0010613
IDA, IMP
Genome Projectpositive regulation of cardiac muscle hypertrophy
GO:0014065
IMP
Genome Projectphosphatidylinositol 3-kinase signaling
GO:0014068
IDA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0014834
IDA
Genome Projectskeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0014896
IMP
Genome Projectmuscle hypertrophy
GO:0014904
IDA
Genome Projectmyotube cell development
GO:0014911
IDA
Genome Projectpositive regulation of smooth muscle cell migration
GO:0021940
IEA
Genome Projectpositive regulation of cerebellar granule cell precursor proliferation
GO:0030104
IEA
Genome Projectwater homeostasis
GO:0030166
IDA, IMP
Genome Projectproteoglycan biosynthetic process
GO:0030168
TAS
Genome Projectplatelet activation
GO:0030324
IEA
Genome Projectlung development
GO:0030335
IMP
Genome Projectpositive regulation of cell migration
GO:0030879
IEA
Genome Projectmammary gland development
GO:0031017
IEA
Genome Projectexocrine pancreas development
GO:0032878
IEA
Genome Projectregulation of establishment or maintenance of cell polarity
GO:0033160
IDA
Genome Projectpositive regulation of protein import into nucleus, translocation
GO:0034392
IDA
Genome Projectnegative regulation of smooth muscle cell apoptotic process
GO:0035264
IEA
Genome Projectmulticellular organism growth
GO:0035630
IDA
Genome Projectbone mineralization involved in bone maturation
GO:0040014
IEP
Genome Projectregulation of multicellular organism growth
GO:0042104
IDA
Genome Projectpositive regulation of activated T cell proliferation
GO:0042523
IDA
Genome Projectpositive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043066
IMP
Genome Projectnegative regulation of apoptotic process
GO:0043388
IDA
Genome Projectpositive regulation of DNA binding
GO:0043410
IDA
Genome Projectpositive regulation of MAPK cascade
GO:0043491
IMP
Genome Projectprotein kinase B signaling
GO:0043568
IDA
Genome Projectpositive regulation of insulin-like growth factor receptor signaling pathway
GO:0044267
TAS
Genome Projectcellular protein metabolic process
GO:0045445
IDA
Genome Projectmyoblast differentiation
GO:0045669
IDA
Genome Projectpositive regulation of osteoblast differentiation
GO:0045725
IDA
Genome Projectpositive regulation of glycogen biosynthetic process
GO:0045740
IDA
ISS
Genome Projectpositive regulation of DNA replication
GO:0045821
IDA
Genome Projectpositive regulation of glycolytic process
GO:0045840
IDA
Genome Projectpositive regulation of mitotic nuclear division
GO:0045893
IDA, IMP
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046326
IDA
Genome Projectpositive regulation of glucose import
GO:0046579
IDA
Genome Projectpositive regulation of Ras protein signal transduction
GO:0048009
IEA
Genome Projectinsulin-like growth factor receptor signaling pathway
GO:0048015
IDA
Genome Projectphosphatidylinositol-mediated signaling
GO:0048146
IDA
Genome Projectpositive regulation of fibroblast proliferation
GO:0048286
IEA
Genome Projectlung alveolus development
GO:0048468
IEA
Genome Projectcell development
GO:0048661
IDA
Genome Projectpositive regulation of smooth muscle cell proliferation
GO:0048754
IEA
Genome Projectbranching morphogenesis of an epithelial tube
GO:0048839
IEA
Genome Projectinner ear development
GO:0050650
IEA
Genome Projectchondroitin sulfate proteoglycan biosynthetic process
GO:0050679
IDA
Genome Projectpositive regulation of epithelial cell proliferation
GO:0050714
IMP
Genome Projectpositive regulation of protein secretion
GO:0050731
IDA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0050821
IMP
Genome Projectprotein stabilization
GO:0051246
IEA
Genome Projectregulation of protein metabolic process
GO:0051450
IDA
Genome Projectmyoblast proliferation
GO:0051897
IEA
Genome Projectpositive regulation of protein kinase B signaling
GO:0060283
IMP
Genome Projectnegative regulation of oocyte development
GO:0060426
IEA
Genome Projectlung vasculature development
GO:0060463
IEA
Genome Projectlung lobe morphogenesis
GO:0060509
IEA
Genome ProjectType I pneumocyte differentiation
GO:0060510
IEA
Genome ProjectType II pneumocyte differentiation
GO:0060527
IEA
Genome Projectprostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060736
IEA
Genome Projectprostate gland growth
GO:0060740
IEA
Genome Projectprostate gland epithelium morphogenesis
GO:0060741
IEA
Genome Projectprostate gland stromal morphogenesis
GO:0060766
IEA
Genome Projectnegative regulation of androgen receptor signaling pathway
GO:0070371
IMP
Genome ProjectERK1 and ERK2 cascade
GO:0070373
IEA
Genome Projectnegative regulation of ERK1 and ERK2 cascade
GO:0070886
IDA
Genome Projectpositive regulation of calcineurin-NFAT signaling cascade
GO:0090201
ISS
Genome Projectnegative regulation of release of cytochrome c from mitochondria
GO:0097192
IEA
Genome Projectextrinsic apoptotic signaling pathway in absence of ligand
GO:1904075
IMP
Genome Projectpositive regulation of trophectodermal cell proliferation
GO:2000288
IEA
Genome Projectpositive regulation of myoblast proliferation
GO:2000679
IDA
Genome Projectpositive regulation of transcription regulatory region DNA binding
GO:2001237
IDA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005158
IPI
Genome Projectinsulin receptor binding
GO:0005159
IPI, IMP
Genome Projectinsulin-like growth factor receptor binding
GO:0005178
IDA
Genome Projectintegrin binding
GO:0005179
IDA
TAS, IEA
Genome Projecthormone activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008083
IEA
Genome Projectgrowth factor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
TAS, NAS, IEA
Genome Projectextracellular region
GO:0005615
IDA
IEA
Genome Projectextracellular space
GO:0005886
TAS
Genome Projectplasma membrane
GO:0016942
IC
Genome Projectinsulin-like growth factor binding protein complex
GO:0031093
TAS
Genome Projectplatelet alpha granule lumen
GO:0042567
IDA
Genome Projectinsulin-like growth factor ternary complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR016179Insulin-like
IPR022341Insulin-like growth factor I
IPR022350Insulin-like growth factor
IPR022352Insulin family
IPR022353Insulin, conserved site

No MapMan annotations defined for this gene.