Gene: ENSG00000016082 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000016082
Transcript Identifier
ENST00000230658
Gene Type
Coding gene
Location
5 : 51383672-51393610 : positive

Family Information

Homologous gene family
HOM03P001943
(42 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P015371
(6 genes in 4 species)
specific family

Descriptions

gene_descr
ISL LIM homeobox 1

Identifiers

Type Value
pidENSP00000230658
HGNC6132
UniprotP61371

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
ISS
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001755
IEA
Genome Projectneural crest cell migration
GO:0003007
IEA
Genome Projectheart morphogenesis
GO:0003139
IMP
Genome Projectsecondary heart field specification
GO:0003148
ISS
IEA
Genome Projectoutflow tract septum morphogenesis
GO:0003151
ISS
IEA
Genome Projectoutflow tract morphogenesis
GO:0003203
ISS
IEA
Genome Projectendocardial cushion morphogenesis
GO:0003215
ISS
IEA
Genome Projectcardiac right ventricle morphogenesis
GO:0003266
IEA
Genome Projectregulation of secondary heart field cardioblast proliferation
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006366
IEA
Genome Projecttranscription from RNA polymerase II promoter
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007507
IEA
Genome Projectheart development
GO:0008284
IEA
Genome Projectpositive regulation of cell proliferation
GO:0010468
IEA
Genome Projectregulation of gene expression
GO:0010575
ISS
IEA
Genome Projectpositive regulation of vascular endothelial growth factor production
GO:0021520
IEA
Genome Projectspinal cord motor neuron cell fate specification
GO:0021522
ISS
IEA
Genome Projectspinal cord motor neuron differentiation
GO:0021524
IEA
Genome Projectvisceral motor neuron differentiation
GO:0021559
ISS
IEA
Genome Projecttrigeminal nerve development
GO:0021983
IEA
Genome Projectpituitary gland development
GO:0030182
IEA
Genome Projectneuron differentiation
GO:0031016
ISS
IEA
Genome Projectpancreas development
GO:0031103
IEA
Genome Projectaxon regeneration
GO:0031290
IEA
Genome Projectretinal ganglion cell axon guidance
GO:0032024
IC, IEA
Genome Projectpositive regulation of insulin secretion
GO:0032725
ISS
IEA
Genome Projectpositive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729
ISS
IEA
Genome Projectpositive regulation of interferon-gamma production
GO:0032730
ISS
IEA
Genome Projectpositive regulation of interleukin-1 alpha production
GO:0032731
ISS
IEA
Genome Projectpositive regulation of interleukin-1 beta production
GO:0032735
ISS
IEA
Genome Projectpositive regulation of interleukin-12 production
GO:0032755
ISS
IEA
Genome Projectpositive regulation of interleukin-6 production
GO:0032760
ISS
IEA
Genome Projectpositive regulation of tumor necrosis factor production
GO:0033147
ISS
IEA
Genome Projectnegative regulation of intracellular estrogen receptor signaling pathway
GO:0035066
IEA
Genome Projectpositive regulation of histone acetylation
GO:0042517
IEA
Genome Projectpositive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043388
IEA
Genome Projectpositive regulation of DNA binding
GO:0043524
ISS
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0045665
IEA
Genome Projectnegative regulation of neuron differentiation
GO:0045766
ISS
IEA
Genome Projectpositive regulation of angiogenesis
GO:0045944
ISS
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048663
IEA
Genome Projectneuron fate commitment
GO:0048665
ISS
IEA
Genome Projectneuron fate specification
GO:0048762
ISS
IEA
Genome Projectmesenchymal cell differentiation
GO:0048880
ISS
IEA
Genome Projectsensory system development
GO:0048935
IEA
Genome Projectperipheral nervous system neuron development
GO:0048936
ISS
IEA
Genome Projectperipheral nervous system neuron axonogenesis
GO:0050728
ISS
IEA
Genome Projectnegative regulation of inflammatory response
GO:0055010
ISS
IEA
Genome Projectventricular cardiac muscle tissue morphogenesis
GO:0060037
ISS
IEA
Genome Projectpharyngeal system development
GO:0060379
IEA
Genome Projectcardiac muscle cell myoblast differentiation
GO:0060384
ISS
IEA
Genome Projectinnervation
GO:0060413
ISS
IEA
Genome Projectatrial septum morphogenesis
GO:0060913
IDA
Genome Projectcardiac cell fate determination
GO:0071385
ISS
IEA
Genome Projectcellular response to glucocorticoid stimulus
GO:0071657
ISS
IEA
Genome Projectpositive regulation of granulocyte colony-stimulating factor production
GO:0090074
ISS
IEA
Genome Projectnegative regulation of protein homodimerization activity
GO:0090090
IEA
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:1901258
ISS
IEA
Genome Projectpositive regulation of macrophage colony-stimulating factor production

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000978
IEA
Genome ProjectRNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077
IEA
Genome Projecttranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001102
IPI
Genome ProjectRNA polymerase II activating transcription factor binding
GO:0001105
IDA
Genome ProjectRNA polymerase II transcription coactivator activity
GO:0001158
IDA
NAS
Genome Projectenhancer sequence-specific DNA binding
GO:0003677
IEA
Genome ProjectDNA binding
GO:0003682
IEA
Genome Projectchromatin binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008270
IEA
Genome Projectzinc ion binding
GO:0016922
ISS
IEA
Genome Projectligand-dependent nuclear receptor binding
GO:0030331
ISS
IEA
Genome Projectestrogen receptor binding
GO:0043425
IPI
Genome ProjectbHLH transcription factor binding
GO:0043565
IEA
Genome Projectsequence-specific DNA binding
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005622
IEA
Genome Projectintracellular
GO:0005634
NAS, IEA
Genome Projectnucleus
GO:0005654
IDA
Genome Projectnucleoplasm
GO:0005737
NAS
Genome Projectcytoplasm
GO:0005739
IDA
Genome Projectmitochondrion

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001356Homeobox domain
IPR001781Zinc finger, LIM-type
IPR009057Homeodomain-like
IPR017970Homeobox, conserved site

No MapMan annotations defined for this gene.