Gene: ENSG00000012504 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000012504
Transcript Identifier
ENST00000551379
Gene Type
Coding gene
Location
12 : 100503388-100563489 : positive

Family Information

Homologous gene family
HOM03P000128
(228 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P072059
(2 genes in 2 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
nuclear receptor subfamily 1, group H, member 4

Identifiers

Type Value
pidENSP00000447149
HGNC7967
UniprotQ96RI1

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
ISS
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001080
IC
Genome Projectnitrogen catabolite activation of transcription from RNA polymerase II promoter
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006357
IEA
Genome Projectregulation of transcription from RNA polymerase II promoter
GO:0006367
TAS
Genome Projecttranscription initiation from RNA polymerase II promoter
GO:0007165
TAS
Genome Projectsignal transduction
GO:0008206
TAS, IEA
Genome Projectbile acid metabolic process
GO:0010467
TAS
Genome Projectgene expression
GO:0015721
TAS
Genome Projectbile acid and bile salt transport
GO:0030522
ISS
IEA
Genome Projectintracellular receptor signaling pathway
GO:0034255
ISS
IEA
Genome Projectregulation of urea metabolic process
GO:0038185
IDA
Genome Projectintracellular bile acid receptor signaling pathway
GO:0043401
IEA
Genome Projectsteroid hormone mediated signaling pathway
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0045944
IMP
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0070857
TAS
Genome Projectregulation of bile acid biosynthetic process
GO:0070858
IDA
Genome Projectnegative regulation of bile acid biosynthetic process
GO:0071417
ISS
IEA
Genome Projectcellular response to organonitrogen compound
GO:0090181
TAS
Genome Projectregulation of cholesterol metabolic process
GO:1903413
ISS
IEA
Genome Projectcellular response to bile acid
GO:2000213
ISS
IEA
Genome Projectpositive regulation of glutamate metabolic process
GO:2001250
IEA
Genome Projectpositive regulation of ammonia assimilation cycle

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000980
IDA
Genome ProjectRNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077
IDA
Genome Projecttranscriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001190
IDA
Genome Projecttranscriptional activator activity, RNA polymerase II transcription factor binding
GO:0003677
IEA
Genome ProjectDNA binding
GO:0003700
TAS, IEA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0003705
IDA
Genome Projecttranscription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0003707
IEA
Genome Projectsteroid hormone receptor activity
GO:0003713
TAS
Genome Projecttranscription coactivator activity
GO:0003714
TAS
Genome Projecttranscription corepressor activity
GO:0004879
ISS
TAS, IEA
Genome ProjectRNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0004887
IEA
Genome Projectthyroid hormone receptor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008270
IEA
Genome Projectzinc ion binding
GO:0016922
TAS
Genome Projectligand-dependent nuclear receptor binding
GO:0032052
ISS
TAS, IEA
Genome Projectbile acid binding
GO:0038181
IDA
Genome Projectbile acid receptor activity
GO:0043565
IDA
IEA
Genome Projectsequence-specific DNA binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0046965
IEA
Genome Projectretinoid X receptor binding
GO:1902122
IDA
Genome Projectchenodeoxycholic acid binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IEA
Genome Projectnucleus
GO:0005654
TAS
Genome Projectnucleoplasm
GO:0005719
IDA
Genome Projectnuclear euchromatin

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000536Nuclear hormone receptor, ligand-binding domain
IPR001628Zinc finger, nuclear hormone receptor-type
IPR001723Nuclear hormone receptor
IPR001728Thyroid hormone receptor
IPR013088Zinc finger, NHR/GATA-type

No MapMan annotations defined for this gene.