Gene: ENSG00000010810 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000010810
Transcript Identifier
ENST00000368667
Gene Type
Coding gene
Location
6 : 111661739-111720051 : negative

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P005517
(15 genes in 3 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
FYN proto-oncogene, Src family tyrosine kinase

Identifiers

Type Value
pidENSP00000357656
HGNC4037
UniprotP06241

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001764
IEA
Genome Projectneuron migration
GO:0002223
TAS
Genome Projectstimulatory C-type lectin receptor signaling pathway
GO:0002250
IEA
Genome Projectadaptive immune response
GO:0002376
IEA
Genome Projectimmune system process
GO:0006468
TAS, NAS, IEA
Genome Projectprotein phosphorylation
GO:0006816
NAS
Genome Projectcalcium ion transport
GO:0007166
IEA
Genome Projectcell surface receptor signaling pathway
GO:0007169
IBA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173
TAS
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007411
TAS
Genome Projectaxon guidance
GO:0007596
TAS
Genome Projectblood coagulation
GO:0007612
TAS
Genome Projectlearning
GO:0007631
TAS
Genome Projectfeeding behavior
GO:0008360
IEA
Genome Projectregulation of cell shape
GO:0008543
TAS
Genome Projectfibroblast growth factor receptor signaling pathway
GO:0010629
IEA
Genome Projectnegative regulation of gene expression
GO:0010976
IEA
Genome Projectpositive regulation of neuron projection development
GO:0014068
IEA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0016032
TAS, IEA
Genome Projectviral process
GO:0016310
IEA
Genome Projectphosphorylation
GO:0016477
IBA
Genome Projectcell migration
GO:0018108
IMP
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0030154
IBA
Genome Projectcell differentiation
GO:0030168
TAS
Genome Projectplatelet activation
GO:0030900
IEA
Genome Projectforebrain development
GO:0031295
TAS
Genome ProjectT cell costimulation
GO:0031397
IEA
Genome Projectnegative regulation of protein ubiquitination
GO:0035556
TAS
Genome Projectintracellular signal transduction
GO:0036120
IEA
Genome Projectcellular response to platelet-derived growth factor stimulus
GO:0038083
IBA
Genome Projectpeptidyl-tyrosine autophosphorylation
GO:0038095
TAS
Genome ProjectFc-epsilon receptor signaling pathway
GO:0038096
TAS
Genome ProjectFc-gamma receptor signaling pathway involved in phagocytosis
GO:0042110
IBA
Genome ProjectT cell activation
GO:0042127
IBA
Genome Projectregulation of cell proliferation
GO:0042177
IEA
Genome Projectnegative regulation of protein catabolic process
GO:0042493
IEA
Genome Projectresponse to drug
GO:0042523
IEA
Genome Projectpositive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042981
IBA
Genome Projectregulation of apoptotic process
GO:0043123
IEA
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043524
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0045087
IBA
TAS
Genome Projectinnate immune response
GO:0045471
IEA
Genome Projectresponse to ethanol
GO:0046777
IEA
Genome Projectprotein autophosphorylation
GO:0048010
TAS
Genome Projectvascular endothelial growth factor receptor signaling pathway
GO:0048011
TAS
Genome Projectneurotrophin TRK receptor signaling pathway
GO:0048013
TAS
Genome Projectephrin receptor signaling pathway
GO:0048015
TAS
Genome Projectphosphatidylinositol-mediated signaling
GO:0048813
IEA
Genome Projectdendrite morphogenesis
GO:0050690
TAS
Genome Projectregulation of defense response to virus by virus
GO:0050798
IEA
Genome Projectactivated T cell proliferation
GO:0050852
IDA
Genome ProjectT cell receptor signaling pathway
GO:0050900
TAS
Genome Projectleukocyte migration
GO:0050966
IEA
Genome Projectdetection of mechanical stimulus involved in sensory perception of pain
GO:0071363
IEA
Genome Projectcellular response to growth factor stimulus
GO:0071375
IBA
IEA
Genome Projectcellular response to peptide hormone stimulus
GO:0071560
IEA
Genome Projectcellular response to transforming growth factor beta stimulus
GO:1900182
IEA
Genome Projectpositive regulation of protein localization to nucleus
GO:2001240
IEA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0001664
IEA
Genome ProjectG-protein coupled receptor binding
GO:0001948
IPI
IEA
Genome Projectglycoprotein binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
EXP, IMP
TAS, IEA
Genome Projectprotein tyrosine kinase activity
GO:0004715
IBA
NAS, IEA
Genome Projectnon-membrane spanning protein tyrosine kinase activity
GO:0005102
IEA
Genome Projectreceptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0015631
IEA
Genome Projecttubulin binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0032403
IEA
Genome Projectprotein complex binding
GO:0042608
IEA
Genome ProjectT cell receptor binding
GO:0042609
IEA
Genome ProjectCD4 receptor binding
GO:0042610
IEA
Genome ProjectCD8 receptor binding
GO:0043548
IEA
Genome Projectphosphatidylinositol 3-kinase binding
GO:0044325
IEA
Genome Projection channel binding
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0046875
IPI
Genome Projectephrin receptor binding
GO:0051428
IEA
Genome Projectpeptide hormone receptor binding
GO:0070851
IPI
Genome Projectgrowth factor receptor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IEA
Genome Projectnucleus
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005739
IEA
Genome Projectmitochondrion
GO:0005768
IDA
Genome Projectendosome
GO:0005829
TAS
Genome Projectcytosol
GO:0005884
IEA
Genome Projectactin filament
GO:0005886
IDA
IEA
Genome Projectplasma membrane
GO:0014069
IEA
Genome Projectpostsynaptic density
GO:0016020
IEA
Genome Projectmembrane
GO:0031234
IBA
Genome Projectextrinsic component of cytoplasmic side of plasma membrane
GO:0043231
IEA
Genome Projectintracellular membrane-bounded organelle
GO:0071944
IEA
Genome Projectcell periphery
GO:0045121
IDA
Genome Projectmembrane raft

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR000980SH2 domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452SH3 domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain

No MapMan annotations defined for this gene.