Gene: ENSG00000004487 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000004487
Transcript Identifier
ENST00000400181
Gene Type
Coding gene
Location
1 : 23019597-23083364 : positive

Family Information

Homologous gene family
HOM03P000222
(160 genes in 36 species)
specific family
Orthologous gene family
ORTHO03P003422
(24 genes in 22 species)
specific family

Descriptions

gene_descr
lysine (K)-specific demethylase 1A

Identifiers

Type Value
pidENSP00000383042
HGNC29079
UniprotO60341

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IMP
ISS
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001701
IEA
Genome Projectin utero embryonic development
GO:0006325
TAS
Genome Projectchromatin organization
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006357
IMP
Genome Projectregulation of transcription from RNA polymerase II promoter
GO:0006482
IMP
Genome Projectprotein demethylation
GO:0007264
TAS
Genome Projectsmall GTPase mediated signal transduction
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007596
TAS
Genome Projectblood coagulation
GO:0008283
IEA
Genome Projectcell proliferation
GO:0010725
IEA
Genome Projectregulation of primitive erythrocyte differentiation
GO:0016568
IEA
Genome Projectchromatin modification
GO:0021983
IEA
Genome Projectpituitary gland development
GO:0030851
IEA
Genome Projectgranulocyte differentiation
GO:0032091
IMP
Genome Projectnegative regulation of protein binding
GO:0033169
IDA
Genome Projecthistone H3-K9 demethylation
GO:0034720
IDA
IEA
Genome Projecthistone H3-K4 demethylation
GO:0043392
IC
Genome Projectnegative regulation of DNA binding
GO:0043433
IDA, IMP
Genome Projectnegative regulation of sequence-specific DNA binding transcription factor activity
GO:0043518
IMP
Genome Projectnegative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045648
IEA
Genome Projectpositive regulation of erythrocyte differentiation
GO:0045654
IEA
Genome Projectpositive regulation of megakaryocyte differentiation
GO:0045892
IDA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045944
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046886
IEA
Genome Projectpositive regulation of hormone biosynthetic process
GO:0051091
IDA
Genome Projectpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0051572
IEA
Genome Projectnegative regulation of histone H3-K4 methylation
GO:0051573
IEA
Genome Projectnegative regulation of histone H3-K9 methylation
GO:0055001
ISS
IEA
Genome Projectmuscle cell development
GO:0055114
IEA
Genome Projectoxidation-reduction process
GO:1902166
IMP
Genome Projectnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000179
IEA
Genome Projectpositive regulation of neural precursor cell proliferation
GO:2000648
IEA
Genome Projectpositive regulation of stem cell proliferation

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001085
IEA
Genome ProjectRNA polymerase II transcription factor binding
GO:0002039
IPI
Genome Projectp53 binding
GO:0003677
IEA
Genome ProjectDNA binding
GO:0003682
IDA
Genome Projectchromatin binding
GO:0003700
IEA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008134
IDA
Genome Projecttranscription factor binding
GO:0016491
IDA
IEA
Genome Projectoxidoreductase activity
GO:0019899
IPI
Genome Projectenzyme binding
GO:0030374
IMP
Genome Projectligand-dependent nuclear receptor transcription coactivator activity
GO:0032451
IMP
Genome Projectdemethylase activity
GO:0032452
EXP, IDA
Genome Projecthistone demethylase activity
GO:0032453
IDA
Genome Projecthistone demethylase activity (H3-K4 specific)
GO:0032454
IDA
Genome Projecthistone demethylase activity (H3-K9 specific)
GO:0034648
IDA
Genome Projecthistone demethylase activity (H3-dimethyl-K4 specific)
GO:0043426
IDA
Genome ProjectMRF binding
GO:0044212
ISS
IEA
Genome Projecttranscription regulatory region DNA binding
GO:0050660
IDA
IEA
Genome Projectflavin adenine dinucleotide binding
GO:0050681
IDA
Genome Projectandrogen receptor binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000790
IDA
ISS
Genome Projectnuclear chromatin
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005654
IDA
TAS
Genome Projectnucleoplasm
GO:0005667
ISS
IEA
Genome Projecttranscription factor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR002937Amine oxidase
IPR007526SWIRM domain
IPR009057Homeodomain-like
IPR011991Winged helix-turn-helix DNA-binding domain
IPR017366Histone lysine-specific demethylase
IPR023753FAD/NAD(P)-binding domain

No MapMan annotations defined for this gene.