Gene: ENSG00000003402 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000003402
Transcript Identifier
ENST00000423241
Gene Type
Coding gene
Location
2 : 201129866-201163973 : positive

Family Information

Homologous gene family
HOM03P041828
(2 genes in 2 species)
specific family

Descriptions

gene_descr
CASP8 and FADD-like apoptosis regulator

Identifiers

Type Value
pidENSP00000399420
HGNC1876
UniprotO15519
UniprotA0A024R3Z7

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006508
IEA
Genome Projectproteolysis
GO:0006915
IMP
TAS, IEA
Genome Projectapoptotic process
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0043066
TAS, IEA
Genome Projectnegative regulation of apoptotic process
GO:0006919
IBA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007519
ISS
Genome Projectskeletal muscle tissue development
GO:0010939
TAS
Genome Projectregulation of necrotic cell death
GO:0012501
TAS
Genome Projectprogrammed cell death
GO:0014732
ISS
Genome Projectskeletal muscle atrophy
GO:0014842
ISS
Genome Projectregulation of skeletal muscle satellite cell proliferation
GO:0014866
ISS
Genome Projectskeletal myofibril assembly
GO:0016032
IEA
Genome Projectviral process
GO:0043123
IEP
Genome Projectpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043154
TAS
Genome Projectnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043403
ISS
Genome Projectskeletal muscle tissue regeneration
GO:0051092
ISS
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0060544
IDA
Genome Projectregulation of necroptotic process
GO:0070266
TAS
Genome Projectnecroptotic process
GO:0097191
TAS
Genome Projectextrinsic apoptotic signaling pathway
GO:0097296
TAS
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097300
TAS
Genome Projectprogrammed necrotic cell death
GO:1901740
ISS
Genome Projectnegative regulation of myoblast fusion
GO:1902041
TAS
Genome Projectregulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042
IMP
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001237
IDA, IMP
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0002020
IPI
IEA
Genome Projectprotease binding
GO:0004197
IEA
Genome Projectcysteine-type endopeptidase activity
GO:0005123
IEA
Genome Projectdeath receptor binding
GO:0008234
IEA
Genome Projectcysteine-type peptidase activity
GO:0032403
IEA
Genome Projectprotein complex binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008047
IDA
Genome Projectenzyme activator activity
GO:0035877
IBA
Genome Projectdeath effector domain binding
GO:0097199
IBA
Genome Projectcysteine-type endopeptidase activity involved in apoptotic signaling pathway

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0031264
IDA
IEA
Genome Projectdeath-inducing signaling complex
GO:0031265
IEA
Genome ProjectCD95 death-inducing signaling complex
GO:0045121
IEA
Genome Projectmembrane raft
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005829
TAS
Genome Projectcytosol
GO:0097342
IDA
Genome Projectripoptosome

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001309Peptidase C14, ICE, catalytic subunit p20
IPR001875Death effector domain
IPR011029Death-like domain
IPR011600Peptidase C14, caspase domain
IPR015917Peptidase C14A, caspase precursor p45, core
IPR029030Caspase-like domain

No MapMan annotations defined for this gene.