Gene: ENSG00000001084 (Homo sapiens)

Overview top

Gene Identifier
ENSG00000001084
Transcript Identifier
ENST00000229416
Gene Type
Coding gene
Location
6 : 53498756-53544645 : negative

Family Information

Homologous gene family
HOM03P002986
(32 genes in 19 species)
specific family
Orthologous gene family
ORTHO03P003173
(25 genes in 19 species)
specific family

Descriptions

gene_descr
glutamate-cysteine ligase, catalytic subunit

Identifiers

Type Value
pidENSP00000229416
HGNC4311
UniprotP48506
UniprotQ14TF0

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000096
TAS
Genome Projectsulfur amino acid metabolic process
GO:0006534
IDA
Genome Projectcysteine metabolic process
GO:0006536
IDA
Genome Projectglutamate metabolic process
GO:0006749
IEA
Genome Projectglutathione metabolic process
GO:0006750
IDA, IMP
TAS, IEA
Genome Projectglutathione biosynthetic process
GO:0006805
TAS
Genome Projectxenobiotic metabolic process
GO:0006979
IDA
Genome Projectresponse to oxidative stress
GO:0008637
IEA
Genome Projectapoptotic mitochondrial changes
GO:0009408
IDA
Genome Projectresponse to heat
GO:0009410
IEA
Genome Projectresponse to xenobiotic stimulus
GO:0009725
IDA
Genome Projectresponse to hormone
GO:0019852
IEA
Genome ProjectL-ascorbic acid metabolic process
GO:0031397
IEA
Genome Projectnegative regulation of protein ubiquitination
GO:0032436
IEA
Genome Projectpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034641
TAS
Genome Projectcellular nitrogen compound metabolic process
GO:0043066
IDA
Genome Projectnegative regulation of apoptotic process
GO:0043524
IEA
Genome Projectnegative regulation of neuron apoptotic process
GO:0044281
TAS
Genome Projectsmall molecule metabolic process
GO:0045454
IDA
Genome Projectcell redox homeostasis
GO:0045892
IDA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0046685
IEA
Genome Projectresponse to arsenic-containing substance
GO:0050880
IMP
Genome Projectregulation of blood vessel size
GO:0051409
IEA
Genome Projectresponse to nitrosative stress
GO:0051900
IEA
Genome Projectregulation of mitochondrial depolarization
GO:1901687
TAS
Genome Projectglutathione derivative biosynthetic process
GO:2001237
IEA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0000287
IDA
Genome Projectmagnesium ion binding
GO:0004357
IDA, IMP
IEA
Genome Projectglutamate-cysteine ligase activity
GO:0005524
IEA
Genome ProjectATP binding
GO:0016595
IDA
Genome Projectglutamate binding
GO:0016874
IEA
Genome Projectligase activity
GO:0043531
IDA
Genome ProjectADP binding
GO:0046982
IEA
Genome Projectprotein heterodimerization activity
GO:0050662
IPI
Genome Projectcoenzyme binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005829
TAS, IEA
Genome Projectcytosol
GO:0017109
IBA
IEA
Genome Projectglutamate-cysteine ligase complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR004308Glutamate-cysteine ligase catalytic subunit

No MapMan annotations defined for this gene.