Gene: YOL090W (Saccharomyces cerevisiae strain S288C)

Overview top

Gene Identifier
YOL090W
Transcript Identifier
YOL090W
Gene Type
Coding gene
Location
XV : 147382-150276 : positive

Family Information

Homologous gene family
HOM02SEM000161
(159 genes in 26 species)
specific family
Orthologous gene family
ORTHO02SEM000252
(109 genes in 26 species)
specific family

Descriptions

gene_descr
Protein that binds to DNA mismatches; forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP

Identifiers

Type Value
pidYOL090W
UniprotP25847
RefSeq_mRNANM_001183344.1
EMBLBK006948
EMBLM84170
EMBLX83121
EMBLZ74832
SGDS000005450

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0036297
IGI
Genome Projectinterstrand cross-link repair
GO:0036297
IGI
Gene Ontologyinterstrand cross-link repair1
GO:0045128
IBA
Genome Projectnegative regulation of reciprocal meiotic recombination
GO:0006974
IEA
Genome Projectcellular response to DNA damage stimulus
GO:0007131
IBA
Genome Projectreciprocal meiotic recombination
GO:0043570
IBA
Genome Projectmaintenance of DNA repeat elements
GO:0006281
IEA
Genome ProjectDNA repair
GO:0000710
IMP
Genome Projectmeiotic mismatch repair
GO:0000710
IMP
Gene Ontologymeiotic mismatch repair2 3 4
GO:0006298
IMP
IEA
Genome Projectmismatch repair
GO:0006298
IMP
Gene Ontologymismatch repair5 6
GO:0000735
IMP, IGI
Genome Projectremoval of nonhomologous ends
GO:0000735
IMP, IGI
Gene Ontologyremoval of nonhomologous ends6 7
GO:0006311
IMP
Genome Projectmeiotic gene conversion
GO:0006311
IMP
Gene Ontologymeiotic gene conversion2
GO:0043111
IMP
Genome Projectreplication fork arrest
GO:0043111
IMP
Gene Ontologyreplication fork arrest8
GO:0030466
IGI
Genome Projectchromatin silencing at silent mating-type cassette
GO:0030466
IGI
Gene Ontologychromatin silencing at silent mating-type cassette9
GO:0006310
IMP
Genome ProjectDNA recombination
GO:0006310
IMP
Gene OntologyDNA recombination10
GO:0006312
IMP
Genome Projectmitotic recombination
GO:0006312
IMP
Gene Ontologymitotic recombination11
GO:0006301
IBA
Genome Projectpostreplication repair
GO:0070727
IEA
PLAZA Integrative Orthologycellular macromolecule localization ENSG00000095002
GO:0007531
IEA
PLAZA Integrative Orthologymating type determination SPBC19G7.01c
GO:0051095
IEA
PLAZA Integrative Orthologyregulation of helicase activity ENSG00000095002
GO:0008104
IEA
PLAZA Integrative Orthologyprotein localization ENSG00000095002
GO:0051096
IEA
PLAZA Integrative Orthologypositive regulation of helicase activity ENSG00000095002
GO:0042771
IEA
PLAZA Integrative Orthologyintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator WBGene00003418
GO:0007530
IEA
PLAZA Integrative Orthologysex determination SPBC19G7.01c
GO:0007533
IEA
PLAZA Integrative Orthologymating type switching SPBC19G7.01c
GO:0007534
IEA
PLAZA Integrative Orthologygene conversion at mating-type locus SPBC19G7.01c
GO:0003006
IEA
PLAZA Integrative Orthologydevelopmental process involved in reproduction SPBC19G7.01c
GO:0051641
IEA
PLAZA Integrative Orthologycellular localization ENSG00000095002
GO:0008219
IEA
PLAZA Integrative Orthologycell death WBGene00003418
GO:0050790
IEA
PLAZA Integrative Orthologyregulation of catalytic activity ENSG00000095002
GO:0006915
IEA
PLAZA Integrative Orthologyapoptotic process WBGene00003418
GO:0035556
IEA
PLAZA Integrative Orthologyintracellular signal transduction WBGene00003418
GO:0034502
IEA
PLAZA Integrative Orthologyprotein localization to chromosome ENSG00000095002
GO:0006290
IEA
PLAZA Integrative Orthologypyrimidine dimer repair AT4G02070
GO:0008630
IEA
PLAZA Integrative Orthologyintrinsic apoptotic signaling pathway in response to DNA damage WBGene00003418
GO:0065009
IEA
PLAZA Integrative Orthologyregulation of molecular function ENSG00000095002
GO:0044093
IEA
PLAZA Integrative Orthologypositive regulation of molecular function ENSG00000095002
GO:0051179
IEA
PLAZA Integrative Orthologylocalization ENSG00000095002
GO:0043085
IEA
PLAZA Integrative Orthologypositive regulation of catalytic activity ENSG00000095002
GO:0071168
IEA
PLAZA Integrative Orthologyprotein localization to chromatin ENSG00000095002
GO:0072332
IEA
PLAZA Integrative Orthologyintrinsic apoptotic signaling pathway by p53 class mediator WBGene00003418
GO:0023052
IEA
PLAZA Integrative Orthologysignaling WBGene00003418
GO:0072331
IEA
PLAZA Integrative Orthologysignal transduction by p53 class mediator WBGene00003418
GO:0033365
IEA
PLAZA Integrative Orthologyprotein localization to organelle ENSG00000095002
GO:0034613
IEA
PLAZA Integrative Orthologycellular protein localization ENSG00000095002
GO:0051336
IEA
PLAZA Integrative Orthologyregulation of hydrolase activity ENSG00000095002
GO:0007154
IEA
PLAZA Integrative Orthologycell communication WBGene00003418
GO:0097190
IEA
PLAZA Integrative Orthologyapoptotic signaling pathway WBGene00003418
GO:0097193
IEA
PLAZA Integrative Orthologyintrinsic apoptotic signaling pathway WBGene00003418
GO:0051345
IEA
PLAZA Integrative Orthologypositive regulation of hydrolase activity ENSG00000095002
GO:0032505
IEA
PLAZA Integrative Orthologyreproduction of a single-celled organism SPBC19G7.01c
GO:0033036
IEA
PLAZA Integrative Orthologymacromolecule localization ENSG00000095002
GO:0032502
IEA
PLAZA Integrative Orthologydevelopmental process SPBC19G7.01c
GO:0007165
IEA
PLAZA Integrative Orthologysignal transduction WBGene00003418
GO:0022413
IEA
PLAZA Integrative Orthologyreproductive process in single-celled organism SPBC19G7.01c
GO:0048869
IEA
PLAZA Integrative Orthologycellular developmental process SPBC19G7.01c
GO:0045165
IEA
PLAZA Integrative Orthologycell fate commitment SPBC19G7.01c
GO:0030154
IEA
PLAZA Integrative Orthologycell differentiation SPBC19G7.01c
GO:0012501
IEA
PLAZA Integrative Orthologyprogrammed cell death WBGene00003418

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003684
IBA
Genome Projectdamaged DNA binding
GO:0003677
IEA
Genome ProjectDNA binding
GO:0005524
IDA
IEA
Genome ProjectATP binding
GO:0005524
IDA
Gene OntologyATP binding12
GO:0032138
IDA, IMP
Genome Projectsingle base insertion or deletion binding
GO:0032138
IDA, IMP
Gene Ontologysingle base insertion or deletion binding13 14
GO:0032137
IDA
Genome Projectguanine/thymine mispair binding
GO:0032137
IDA
Gene Ontologyguanine/thymine mispair binding13
GO:0032135
IDA
Genome ProjectDNA insertion or deletion binding
GO:0032135
IDA
Gene OntologyDNA insertion or deletion binding15
GO:0000400
IDA
Genome Projectfour-way junction DNA binding
GO:0000400
IDA
Gene Ontologyfour-way junction DNA binding16 17
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0030983
IEA
Genome Projectmismatched DNA binding
GO:0016887
IDA
Genome ProjectATPase activity
GO:0016887
IDA
Gene OntologyATPase activity18
GO:0000406
IDA
Genome Projectdouble-strand/single-strand DNA junction binding
GO:0000406
IDA
Gene Ontologydouble-strand/single-strand DNA junction binding19
GO:0000404
IDA
Genome Projectheteroduplex DNA loop binding
GO:0000404
IDA
Gene Ontologyheteroduplex DNA loop binding19
GO:0000403
IDA
Genome ProjectY-form DNA binding
GO:0000403
IDA
Gene OntologyY-form DNA binding19
GO:0008022
IEA
PLAZA Integrative Orthologyprotein C-terminus binding ENSG00000095002
GO:0003697
IEA
PLAZA Integrative Orthologysingle-stranded DNA binding ENSG00000095002
GO:0044877
IEA
PLAZA Integrative Orthologyprotein-containing complex binding ENSG00000095002
GO:0032405
IEA
PLAZA Integrative OrthologyMutLalpha complex binding ENSG00000095002
GO:0032404
IEA
PLAZA Integrative Orthologymismatch repair complex binding ENSG00000095002
GO:0140034
IEA
PLAZA Integrative Orthologymethylation-dependent protein binding ENSG00000116062
GO:0019901
IEA
PLAZA Integrative Orthologyprotein kinase binding ENSG00000095002
GO:0140030
IEA
PLAZA Integrative Orthologymodification-dependent protein binding ENSG00000116062
GO:0046983
IEA
PLAZA Integrative Orthologyprotein dimerization activity ENSG00000095002
GO:0005515
IEA
PLAZA Integrative Orthologyprotein binding AT3G24495
GO:0046872
IEA
PLAZA Integrative Orthologymetal ion binding ENSG00000095002
GO:0042393
IEA
PLAZA Integrative Orthologyhistone binding ENSG00000116062
GO:0032356
IEA
PLAZA Integrative Orthologyoxidized DNA binding ENSG00000095002
GO:0032357
IEA
PLAZA Integrative Orthologyoxidized purine DNA binding ENSG00000095002
GO:0035064
IEA
PLAZA Integrative Orthologymethylated histone binding ENSG00000116062
GO:0043169
IEA
PLAZA Integrative Orthologycation binding ENSG00000095002
GO:0000287
IEA
PLAZA Integrative Orthologymagnesium ion binding ENSG00000095002
GO:0019900
IEA
PLAZA Integrative Orthologykinase binding ENSG00000095002
GO:0042802
IEA
PLAZA Integrative Orthologyidentical protein binding ENSG00000095002
GO:0042803
IEA
PLAZA Integrative Orthologyprotein homodimerization activity ENSG00000095002
GO:0032181
IEA
PLAZA Integrative Orthologydinucleotide repeat insertion binding ENSG00000095002
GO:0032142
IEA
PLAZA Integrative Orthologysingle guanine insertion binding ENSG00000095002
GO:0032143
IEA
PLAZA Integrative Orthologysingle thymine insertion binding ENSG00000095002
GO:0003682
IEA
PLAZA Integrative Orthologychromatin binding ENSG00000095002
GO:0043531
IEA
PLAZA Integrative OrthologyADP binding ENSG00000095002
GO:0032139
IEA
PLAZA Integrative Orthologydinucleotide insertion or deletion binding ENSG00000095002
GO:0019899
IEA
PLAZA Integrative Orthologyenzyme binding ENSG00000095002

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0032300
IEA
Genome Projectmismatch repair complex
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005634
Gene Ontologynucleus20
GO:0032302
IPI
Genome ProjectMutSbeta complex
GO:0032302
IPI
Gene OntologyMutSbeta complex15
GO:0032301
IPI
Genome ProjectMutSalpha complex
GO:0032301
IPI
Gene OntologyMutSalpha complex13
GO:0000228
IDA
Genome Projectnuclear chromosome
GO:0000228
IDA
Gene Ontologynuclear chromosome21
GO:0005794
IEA
PLAZA Integrative OrthologyGolgi apparatus ENSG00000116062
GO:0000781
IEA
PLAZA Integrative Orthologychromosome, telomeric region ENSG00000095002
GO:0005829
IEA
PLAZA Integrative Orthologycytosol SPBC19G7.01c
GO:0044444
IEA
PLAZA Integrative Orthologycytoplasmic part SPBC19G7.01c
GO:0005886
IEA
PLAZA Integrative Orthologyplasma membrane AT3G18524
GO:0000784
IEA
PLAZA Integrative Orthologynuclear chromosome, telomeric region ENSG00000095002
GO:0044454
IEA
PLAZA Integrative Orthologynuclear chromosome part ENSG00000095002
GO:0005654
IEA
PLAZA Integrative Orthologynucleoplasm ENSG00000095002
GO:0044427
IEA
PLAZA Integrative Orthologychromosomal part ENSG00000095002
GO:0005737
IEA
PLAZA Integrative Orthologycytoplasm SPBC19G7.01c
GO:0098687
IEA
PLAZA Integrative Orthologychromosomal region ENSG00000095002
GO:0016020
IEA
PLAZA Integrative Orthologymembrane AT3G18524
GO:0012505
IEA
PLAZA Integrative Orthologyendomembrane system ENSG00000116062
GO:0071944
IEA
PLAZA Integrative Orthologycell periphery AT3G18524

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000432DNA mismatch repair protein MutS, C-terminal
IPR007695DNA mismatch repair protein MutS-like, N-terminal
IPR007696DNA mismatch repair protein MutS, core
IPR007860DNA mismatch repair protein MutS, connector domain
IPR007861DNA mismatch repair protein MutS, clamp
IPR011184DNA mismatch repair Msh2-type
IPR016151DNA mismatch repair protein MutS, N-terminal
IPR027417P-loop containing nucleoside triphosphate hydrolase
IPR032642DNA mismatch repair protein Msh2

No MapMan annotations defined for this gene.
KeggID Description
K19476IST1; vacuolar protein sorting-associated protein IST1
K08735MSH2; DNA mismatch repair protein MSH2
No chloroplast target sequence found.