Gene: YML121W (Saccharomyces cerevisiae strain S288C)

Overview top

Gene Identifier
YML121W
Transcript Identifier
YML121W
Gene Type
Coding gene
Location
XIII : 26930-27862 : positive

Family Information

Homologous gene family
HOM02SEM002826
(26 genes in 21 species)
specific family
Orthologous gene family
ORTHO02SEM002987
(26 genes in 21 species)
specific family

Descriptions

gene_descr
Cytoplasmic GTPase; forms a heterodimer with Gtr2p to stimulate TORC1 in response to amino acids; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB

Identifiers

Type Value
pidYML121W
UniprotQ00582
RefSeq_mRNANM_001182484.1
EMBLAY692917
EMBLBK006946
EMBLD10018
EMBLZ49218
SGDS000004590

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0071230
IBA
Genome Projectcellular response to amino acid stimulus
GO:0006810
IEA
Genome Projecttransport
GO:0010507
IMP, IGI
Genome Projectnegative regulation of autophagy
GO:0010507
IMP, IGI
Gene Ontologynegative regulation of autophagy1
GO:0006817
IMP
IEA
Genome Projectphosphate ion transport
GO:0006817
IMP
Gene Ontologyphosphate ion transport2
GO:1904263
IDA, IMP, IGI
Genome Projectpositive regulation of TORC1 signaling
GO:1904263
IDA, IMP, IGI
Gene Ontologypositive regulation of TORC1 signaling3 4
GO:0006383
IPI, IMP
Genome Projecttranscription by RNA polymerase III
GO:0006383
IPI, IMP
Gene Ontologytranscription by RNA polymerase III5
GO:0006360
IPI, IMP
Genome Projecttranscription by RNA polymerase I
GO:0006360
IPI, IMP
Gene Ontologytranscription by RNA polymerase I5
GO:1903778
IMP
Genome Projectprotein localization to vacuolar membrane
GO:1903778
IMP
Gene Ontologyprotein localization to vacuolar membrane1
GO:0015031
IEA
Genome Projectprotein transport
GO:0006348
IMP
Genome Projectchromatin silencing at telomere
GO:0006348
IMP
Gene Ontologychromatin silencing at telomere6
GO:0009267
IBA
Genome Projectcellular response to starvation
GO:0051239
IEA
PLAZA Integrative Orthologyregulation of multicellular organismal process WBGene00006414
GO:0010648
IEA
PLAZA Integrative Orthologynegative regulation of cell communication SPBC337.13c
GO:0006995
IEA
PLAZA Integrative Orthologycellular response to nitrogen starvation SPBC337.13c
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction WBGene00006414
GO:0007049
IEA
PLAZA Integrative Orthologycell cycle ENSG00000083750
GO:0043412
IEA
PLAZA Integrative Orthologymacromolecule modification ENSG00000155876
GO:0007568
IEA
PLAZA Integrative Orthologyaging WBGene00006414
GO:0048589
IEA
PLAZA Integrative Orthologydevelopmental growth WBGene00006414
GO:0044267
IEA
PLAZA Integrative Orthologycellular protein metabolic process ENSG00000155876
GO:0045919
IEA
PLAZA Integrative Orthologypositive regulation of cytolysis ENSG00000155876
GO:0032501
IEA
PLAZA Integrative Orthologymulticellular organismal process WBGene00006414
GO:0016236
IEA
PLAZA Integrative Orthologymacroautophagy ENSG00000083750
GO:0032502
IEA
PLAZA Integrative Orthologydevelopmental process WBGene00006414
GO:0051701
IEA
PLAZA Integrative Orthologyinteraction with host ENSG00000155876
GO:0051704
IEA
PLAZA Integrative Orthologymulti-organism process ENSG00000155876
GO:0016032
IEA
PLAZA Integrative Orthologyviral process ENSG00000155876
GO:0048585
IEA
PLAZA Integrative Orthologynegative regulation of response to stimulus SPBC337.13c
GO:0009968
IEA
PLAZA Integrative Orthologynegative regulation of signal transduction SPBC337.13c
GO:0032504
IEA
PLAZA Integrative Orthologymulticellular organism reproduction WBGene00006414
GO:0040018
IEA
PLAZA Integrative Orthologypositive regulation of multicellular organism growth WBGene00006414
GO:1902532
IEA
PLAZA Integrative Orthologynegative regulation of intracellular signal transduction SPBC337.13c
GO:1901564
IEA
PLAZA Integrative Orthologyorganonitrogen compound metabolic process ENSG00000155876
GO:0043562
IEA
PLAZA Integrative Orthologycellular response to nitrogen levels SPBC337.13c
GO:0048856
IEA
PLAZA Integrative Orthologyanatomical structure development WBGene00006414
GO:0006464
IEA
PLAZA Integrative Orthologycellular protein modification process ENSG00000155876
GO:0045786
IEA
PLAZA Integrative Orthologynegative regulation of cell cycle ENSG00000083750
GO:0007275
IEA
PLAZA Integrative Orthologymulticellular organism development WBGene00006414
GO:0044419
IEA
PLAZA Integrative Orthologyinterspecies interaction between organisms ENSG00000155876
GO:0040014
IEA
PLAZA Integrative Orthologyregulation of multicellular organism growth WBGene00006414
GO:0019538
IEA
PLAZA Integrative Orthologyprotein metabolic process ENSG00000155876
GO:0035264
IEA
PLAZA Integrative Orthologymulticellular organism growth WBGene00006414
GO:0016567
IEA
PLAZA Integrative Orthologyprotein ubiquitination ENSG00000155876
GO:0035821
IEA
PLAZA Integrative Orthologymodification of morphology or physiology of other organism ENSG00000155876
GO:0016049
IEA
PLAZA Integrative Orthologycell growth FBgn0037647
GO:0016241
IEA
PLAZA Integrative Orthologyregulation of macroautophagy ENSG00000083750
GO:0001558
IEA
PLAZA Integrative Orthologyregulation of cell growth FBgn0037647
GO:0023057
IEA
PLAZA Integrative Orthologynegative regulation of signaling SPBC337.13c
GO:0040007
IEA
PLAZA Integrative Orthologygrowth WBGene00006414
GO:0040008
IEA
PLAZA Integrative Orthologyregulation of growth WBGene00006414
GO:0044403
IEA
PLAZA Integrative Orthologysymbiont process ENSG00000155876
GO:0042268
IEA
PLAZA Integrative Orthologyregulation of cytolysis ENSG00000155876
GO:0044003
IEA
PLAZA Integrative Orthologymodification by symbiont of host morphology or physiology ENSG00000155876
GO:0051817
IEA
PLAZA Integrative Orthologymodification of morphology or physiology of other organism involved in symbiotic interaction ENSG00000155876
GO:1904262
IEA
PLAZA Integrative Orthologynegative regulation of TORC1 signaling SPBC337.13c
GO:0051128
IEA
PLAZA Integrative Orthologyregulation of cellular component organization FBgn0037647
GO:0032446
IEA
PLAZA Integrative Orthologyprotein modification by small protein conjugation ENSG00000155876
GO:1990928
IEA
PLAZA Integrative Orthologyresponse to amino acid starvation ENSG00000083750
GO:0070647
IEA
PLAZA Integrative Orthologyprotein modification by small protein conjugation or removal ENSG00000155876
GO:0032007
IEA
PLAZA Integrative Orthologynegative regulation of TOR signaling SPBC337.13c
GO:0019048
IEA
PLAZA Integrative Orthologymodulation by virus of host morphology or physiology ENSG00000155876
GO:0051726
IEA
PLAZA Integrative Orthologyregulation of cell cycle ENSG00000083750
GO:0010259
IEA
PLAZA Integrative Orthologymulticellular organism aging WBGene00006414
GO:0051240
IEA
PLAZA Integrative Orthologypositive regulation of multicellular organismal process WBGene00006414
GO:0008219
IEA
PLAZA Integrative Orthologycell death ENSG00000155876
GO:0030307
IEA
PLAZA Integrative Orthologypositive regulation of cell growth FBgn0037647
GO:0050793
IEA
PLAZA Integrative Orthologyregulation of developmental process WBGene00006414
GO:1990253
IEA
PLAZA Integrative Orthologycellular response to leucine starvation ENSG00000083750
GO:0048638
IEA
PLAZA Integrative Orthologyregulation of developmental growth WBGene00006414
GO:0048639
IEA
PLAZA Integrative Orthologypositive regulation of developmental growth WBGene00006414
GO:0051094
IEA
PLAZA Integrative Orthologypositive regulation of developmental process WBGene00006414
GO:0022402
IEA
PLAZA Integrative Orthologycell cycle process ENSG00000083750
GO:0008340
IEA
PLAZA Integrative Orthologydetermination of adult lifespan WBGene00006414
GO:0034198
IEA
PLAZA Integrative Orthologycellular response to amino acid starvation ENSG00000083750
GO:0045927
IEA
PLAZA Integrative Orthologypositive regulation of growth WBGene00006414
GO:0036211
IEA
PLAZA Integrative Orthologyprotein modification process ENSG00000155876
GO:0019835
IEA
PLAZA Integrative Orthologycytolysis ENSG00000155876
GO:0007050
IEA
PLAZA Integrative Orthologycell cycle arrest ENSG00000083750

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003924
IDA
Genome ProjectGTPase activity
GO:0003924
IDA
Gene OntologyGTPase activity7 8
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0005525
IEA
Genome ProjectGTP binding
GO:0019899
IEA
PLAZA Integrative Orthologyenzyme binding ENSG00000083750
GO:0044389
IEA
PLAZA Integrative Orthologyubiquitin-like protein ligase binding ENSG00000155876
GO:0042803
IEA
PLAZA Integrative Orthologyprotein homodimerization activity ENSG00000155876
GO:0042802
IEA
PLAZA Integrative Orthologyidentical protein binding ENSG00000155876
GO:0051020
IEA
PLAZA Integrative OrthologyGTPase binding ENSG00000083750
GO:0051219
IEA
PLAZA Integrative Orthologyphosphoprotein binding ENSG00000155876
GO:0031625
IEA
PLAZA Integrative Orthologyubiquitin protein ligase binding ENSG00000155876
GO:0005515
IEA
PLAZA Integrative Orthologyprotein binding ENSG00000083750
GO:0046983
IEA
PLAZA Integrative Orthologyprotein dimerization activity ENSG00000083750
GO:0046982
IEA
PLAZA Integrative Orthologyprotein heterodimerization activity ENSG00000083750

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1990131
IPI
Genome ProjectGtr1-Gtr2 GTPase complex
GO:1990131
IPI
Gene OntologyGtr1-Gtr2 GTPase complex9 10
GO:0000781
IEA
Genome Projectchromosome, telomeric region
GO:0016020
IEA
Genome Projectmembrane
GO:0005774
IEA
Genome Projectvacuolar membrane
GO:0005773
IEA
Genome Projectvacuole
GO:0005764
IBA
Genome Projectlysosome
GO:0000329
IDA
Genome Projectfungal-type vacuole membrane
GO:0000329
IDA
Gene Ontologyfungal-type vacuole membrane3 11 12
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005737
IDA
Gene Ontologycytoplasm9
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus9
GO:0031902
IDA
Genome Projectlate endosome membrane
GO:0031902
IDA
Gene Ontologylate endosome membrane13
GO:0034448
IDA
Genome ProjectEGO complex
GO:0034448
IDA
Gene OntologyEGO complex13
GO:0035859
IEA
PLAZA Integrative OrthologySeh1-associated complex ENSG00000155876
GO:0005765
IEA
PLAZA Integrative Orthologylysosomal membrane ENSG00000083750
GO:0005829
IEA
PLAZA Integrative Orthologycytosol SPBC337.13c
GO:1990130
IEA
PLAZA Integrative OrthologyGATOR1 complex ENSG00000155876

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR006762Gtr1/RagA G protein
IPR027417P-loop containing nucleoside triphosphate hydrolase

No MapMan annotations defined for this gene.
KeggID Description
K16185RRAGA_B; Ras-related GTP-binding protein A/B
No chloroplast target sequence found.