Gene: YLR032W (Saccharomyces cerevisiae strain S288C)

Overview top

Gene Identifier
YLR032W
Transcript Identifier
YLR032W
Gene Type
Coding gene
Location
XII : 204991-208500 : positive

Family Information

Homologous gene family
HOM02SEM000010
(859 genes in 26 species)
specific family

Descriptions

gene_descr
DNA helicase/Ubiquitin ligase; involved in error- free branch of DNA damage tolerance (DDT) pathway; proposed to promote replication fork regression during postreplication repair by template switching; stimulates synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress; associates with native telomeres, cooperates with homologous recombination in senescent cells

Identifiers

Type Value
pidYLR032W
UniprotP32849
RefSeq_mRNANM_001181919.1
EMBLBK006945
EMBLM96644
EMBLS46103
EMBLZ73204
SGDS000004022

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006281
IEA
Genome ProjectDNA repair
GO:0006974
IEA
Genome Projectcellular response to DNA damage stimulus
GO:0000209
IDA
Genome Projectprotein polyubiquitination
GO:0000209
IDA
Gene Ontologyprotein polyubiquitination1
GO:0010994
IDA
Genome Projectfree ubiquitin chain polymerization
GO:0010994
IDA
Gene Ontologyfree ubiquitin chain polymerization1
GO:0042276
IMP
Genome Projecterror-prone translesion synthesis
GO:0042276
IDA, IMP
Gene Ontologyerror-prone translesion synthesis2 3
GO:0006302
IMP, IGI
Genome Projectdouble-strand break repair
GO:0006302
IMP, IGI
Gene Ontologydouble-strand break repair4
GO:0006301
IDA
Genome Projectpostreplication repair
GO:0006301
IDA
Gene Ontologypostreplication repair5
GO:0032508
IEA
Genome ProjectDNA duplex unwinding
GO:0070987
IDA, IMP
Gene Ontologyerror-free translesion synthesis2
GO:0042275
IMP
Gene Ontologyerror-free postreplication DNA repair6
GO:0031323
IEA
PLAZA Integrative Orthologyregulation of cellular metabolic process ENSG00000071794
GO:0050789
IEA
PLAZA Integrative Orthologyregulation of biological process ENSG00000071794
GO:0080090
IEA
PLAZA Integrative Orthologyregulation of primary metabolic process ENSG00000071794
GO:0031326
IEA
PLAZA Integrative Orthologyregulation of cellular biosynthetic process ENSG00000071794
GO:0032774
IEA
PLAZA Integrative OrthologyRNA biosynthetic process ENSG00000071794
GO:0072393
IEA
PLAZA Integrative Orthologymicrotubule anchoring at microtubule organizing center FBgn0002542
GO:0048232
IEA
PLAZA Integrative Orthologymale gamete generation FBgn0002542
GO:0000375
IEA
PLAZA Integrative OrthologyRNA splicing, via transesterification reactions FBgn0037531
GO:0022412
IEA
PLAZA Integrative Orthologycellular process involved in reproduction in multicellular organism FBgn0002542
GO:0007049
IEA
PLAZA Integrative Orthologycell cycle FBgn0002542
GO:0000003
IEA
PLAZA Integrative Orthologyreproduction FBgn0002542
GO:0006353
IEA
PLAZA Integrative OrthologyDNA-templated transcription, termination FBgn0002542
GO:0006397
IEA
PLAZA Integrative OrthologymRNA processing FBgn0037531
GO:0006396
IEA
PLAZA Integrative OrthologyRNA processing FBgn0037531
GO:0022414
IEA
PLAZA Integrative Orthologyreproductive process FBgn0002542
GO:0006355
IEA
PLAZA Integrative Orthologyregulation of transcription, DNA-templated ENSG00000071794
GO:0006310
IEA
PLAZA Integrative OrthologyDNA recombination AT5G22750
GO:0000724
IEA
PLAZA Integrative Orthologydouble-strand break repair via homologous recombination AT5G22750
GO:0000725
IEA
PLAZA Integrative Orthologyrecombinational repair AT5G22750
GO:0007283
IEA
PLAZA Integrative Orthologyspermatogenesis FBgn0002542
GO:0006351
IEA
PLAZA Integrative Orthologytranscription, DNA-templated ENSG00000071794
GO:1903311
IEA
PLAZA Integrative Orthologyregulation of mRNA metabolic process FBgn0037531
GO:0060255
IEA
PLAZA Integrative Orthologyregulation of macromolecule metabolic process ENSG00000071794
GO:0044703
IEA
PLAZA Integrative Orthologymulti-organism reproductive process FBgn0002542
GO:0140013
IEA
PLAZA Integrative Orthologymeiotic nuclear division FBgn0002542
GO:0032501
IEA
PLAZA Integrative Orthologymulticellular organismal process FBgn0002542
GO:0051704
IEA
PLAZA Integrative Orthologymulti-organism process AT5G22750
GO:0019222
IEA
PLAZA Integrative Orthologyregulation of metabolic process ENSG00000071794
GO:0010556
IEA
PLAZA Integrative Orthologyregulation of macromolecule biosynthetic process ENSG00000071794
GO:0000280
IEA
PLAZA Integrative Orthologynuclear division FBgn0002542
GO:0048024
IEA
PLAZA Integrative Orthologyregulation of mRNA splicing, via spliceosome FBgn0037531
GO:0016071
IEA
PLAZA Integrative OrthologymRNA metabolic process FBgn0037531
GO:0032504
IEA
PLAZA Integrative Orthologymulticellular organism reproduction FBgn0002542
GO:0016070
IEA
PLAZA Integrative OrthologyRNA metabolic process ENSG00000071794
GO:0000398
IEA
PLAZA Integrative OrthologymRNA splicing, via spliceosome FBgn0037531
GO:1903506
IEA
PLAZA Integrative Orthologyregulation of nucleic acid-templated transcription ENSG00000071794
GO:0007276
IEA
PLAZA Integrative Orthologygamete generation FBgn0002542
GO:0034453
IEA
PLAZA Integrative Orthologymicrotubule anchoring FBgn0002542
GO:0009292
IEA
PLAZA Integrative Orthologygenetic transfer AT5G22750
GO:0019219
IEA
PLAZA Integrative Orthologyregulation of nucleobase-containing compound metabolic process ENSG00000071794
GO:0009294
IEA
PLAZA Integrative OrthologyDNA mediated transformation AT5G22750
GO:0019953
IEA
PLAZA Integrative Orthologysexual reproduction FBgn0002542
GO:0034454
IEA
PLAZA Integrative Orthologymicrotubule anchoring at centrosome FBgn0002542
GO:0097659
IEA
PLAZA Integrative Orthologynucleic acid-templated transcription ENSG00000071794
GO:0010467
IEA
PLAZA Integrative Orthologygene expression ENSG00000071794
GO:0010468
IEA
PLAZA Integrative Orthologyregulation of gene expression ENSG00000071794
GO:0051252
IEA
PLAZA Integrative Orthologyregulation of RNA metabolic process ENSG00000071794
GO:0043484
IEA
PLAZA Integrative Orthologyregulation of RNA splicing FBgn0037531
GO:0050684
IEA
PLAZA Integrative Orthologyregulation of mRNA processing FBgn0037531
GO:0009889
IEA
PLAZA Integrative Orthologyregulation of biosynthetic process ENSG00000071794
GO:0000226
IEA
PLAZA Integrative Orthologymicrotubule cytoskeleton organization FBgn0002542
GO:0044764
IEA
PLAZA Integrative Orthologymulti-organism cellular process AT5G22750
GO:0007143
IEA
PLAZA Integrative Orthologyfemale meiotic nuclear division FBgn0002542
GO:0048609
IEA
PLAZA Integrative Orthologymulticellular organismal reproductive process FBgn0002542
GO:2001141
IEA
PLAZA Integrative Orthologyregulation of RNA biosynthetic process ENSG00000071794
GO:2000112
IEA
PLAZA Integrative Orthologyregulation of cellular macromolecule biosynthetic process ENSG00000071794
GO:0000380
IEA
PLAZA Integrative Orthologyalternative mRNA splicing, via spliceosome FBgn0037531
GO:0000381
IEA
PLAZA Integrative Orthologyregulation of alternative mRNA splicing, via spliceosome FBgn0037531
GO:0050794
IEA
PLAZA Integrative Orthologyregulation of cellular process ENSG00000071794
GO:0051321
IEA
PLAZA Integrative Orthologymeiotic cell cycle FBgn0002542
GO:0048285
IEA
PLAZA Integrative Orthologyorganelle fission FBgn0002542
GO:0007017
IEA
PLAZA Integrative Orthologymicrotubule-based process FBgn0002542
GO:0000377
IEA
PLAZA Integrative OrthologyRNA splicing, via transesterification reactions with bulged adenosine as nucleophile FBgn0037531
GO:0051171
IEA
PLAZA Integrative Orthologyregulation of nitrogen compound metabolic process ENSG00000071794
GO:0045003
IEA
PLAZA Integrative Orthologydouble-strand break repair via synthesis-dependent strand annealing AT5G22750
GO:0006289
IEA
PLAZA Integrative Orthologynucleotide-excision repair SPAC13G6.01c
GO:0022402
IEA
PLAZA Integrative Orthologycell cycle process FBgn0002542
GO:1903046
IEA
PLAZA Integrative Orthologymeiotic cell cycle process FBgn0002542
GO:0036297
IEA
PLAZA Integrative Orthologyinterstrand cross-link repair AT5G22750
GO:0007010
IEA
PLAZA Integrative Orthologycytoskeleton organization FBgn0002542
GO:0008380
IEA
PLAZA Integrative OrthologyRNA splicing FBgn0037531
GO:0007292
IEA
PLAZA Integrative Orthologyfemale gamete generation FBgn0002542

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005524
IEA
Genome ProjectATP binding
GO:0004386
IEA
Genome Projecthelicase activity
GO:0046872
IEA
Genome Projectmetal ion binding
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0016787
IEA
Genome Projecthydrolase activity
GO:0000400
IDA
Genome Projectfour-way junction DNA binding
GO:0000400
IDA
Gene Ontologyfour-way junction DNA binding5
GO:0000403
IDA
Genome ProjectY-form DNA binding
GO:0000403
IDA
Gene OntologyY-form DNA binding5
GO:0008094
IDA
Genome ProjectDNA-dependent ATPase activity
GO:0008094
IDA
Gene OntologyDNA-dependent ATPase activity5
GO:0009378
IDA
Genome Projectfour-way junction helicase activity
GO:0009378
IDA
Gene Ontologyfour-way junction helicase activity5
GO:0003677
IEA
Genome ProjectDNA binding
GO:0003676
IEA
Genome Projectnucleic acid binding
GO:0016818
IEA
Genome Projecthydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0008270
IEA
Genome Projectzinc ion binding
GO:0019899
IEA
PLAZA Integrative Orthologyenzyme binding ENSG00000071794
GO:0016740
IEA
PLAZA Integrative Orthologytransferase activity SPAC13G6.01c
GO:0004842
IEA
PLAZA Integrative Orthologyubiquitin-protein transferase activity SPAC13G6.01c
GO:0044389
IEA
PLAZA Integrative Orthologyubiquitin-like protein ligase binding ENSG00000071794
GO:0140096
IEA
PLAZA Integrative Orthologycatalytic activity, acting on a protein SPAC13G6.01c
GO:0019787
IEA
PLAZA Integrative Orthologyubiquitin-like protein transferase activity SPAC13G6.01c
GO:0061630
IEA
PLAZA Integrative Orthologyubiquitin protein ligase activity SPAC13G6.01c
GO:0005515
IEA
PLAZA Integrative Orthologyprotein binding ENSG00000071794
GO:0031625
IEA
PLAZA Integrative Orthologyubiquitin protein ligase binding ENSG00000071794
GO:0003723
IEA
PLAZA Integrative OrthologyRNA binding ENSG00000071794
GO:0061659
IEA
PLAZA Integrative Orthologyubiquitin-like protein ligase activity SPAC13G6.01c

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005634
Gene Ontologynucleus7
GO:0005737
IDA
IEA
Genome Projectcytoplasm
GO:0005737
Gene Ontologycytoplasm7
GO:0000790
IDA
Genome Projectnuclear chromatin
GO:0000790
IDA
Gene Ontologynuclear chromatin8
GO:0000781
IDA
Genome Projectchromosome, telomeric region
GO:0000781
IDA
Gene Ontologychromosome, telomeric region9
GO:0016020
IEA
PLAZA Integrative Orthologymembrane ENSG00000071794
GO:0031967
IEA
PLAZA Integrative Orthologyorganelle envelope AT5G43530
GO:0009941
IEA
PLAZA Integrative Orthologychloroplast envelope AT5G43530
GO:0031975
IEA
PLAZA Integrative Orthologyenvelope AT5G43530
GO:0005654
IEA
PLAZA Integrative Orthologynucleoplasm ENSG00000071794
GO:0009536
IEA
PLAZA Integrative Orthologyplastid AT5G43530
GO:0035861
IEA
PLAZA Integrative Orthologysite of double-strand break SPAC13G6.01c
GO:0009526
IEA
PLAZA Integrative Orthologyplastid envelope AT5G43530
GO:0044444
IEA
PLAZA Integrative Orthologycytoplasmic part AT5G43530
GO:0009507
IEA
PLAZA Integrative Orthologychloroplast AT5G43530
GO:0044435
IEA
PLAZA Integrative Orthologyplastid part AT5G43530
GO:0044434
IEA
PLAZA Integrative Orthologychloroplast part AT5G43530
GO:0090734
IEA
PLAZA Integrative Orthologysite of DNA damage SPAC13G6.01c

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000330SNF2-related, N-terminal domain
IPR001650Helicase, C-terminal
IPR001841Zinc finger, RING-type
IPR013083Zinc finger, RING/FYVE/PHD-type
IPR014001Helicase superfamily 1/2, ATP-binding domain
IPR014905HIRAN domain
IPR017907Zinc finger, RING-type, conserved site
IPR027417P-loop containing nucleoside triphosphate hydrolase

No MapMan annotations defined for this gene.
KeggID Description
K15505RAD5; DNA repair protein RAD5 [EC:3.6.4.-]
No chloroplast target sequence found.