Gene: YDR440W (Saccharomyces cerevisiae strain S288C)

Overview top

Gene Identifier
YDR440W
Transcript Identifier
YDR440W
Gene Type
Coding gene
Location
IV : 1342493-1344241 : positive

Family Information

Homologous gene family
HOM02SEM009288
(10 genes in 5 species)
specific family
Orthologous gene family
ORTHO02SEM008003
(10 genes in 5 species)
specific family

Descriptions

gene_descr
Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response

Identifiers

Type Value
pidYDR440W
UniprotQ04089
RefSeq_mRNANM_001180748.1
EMBLBK006938
EMBLU33007
SGDS000002848

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0032259
IEA
Genome Projectmethylation
GO:0016569
IEA
Genome Projectcovalent chromatin modification
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0051598
IGI
Genome Projectmeiotic recombination checkpoint
GO:0051598
IGI
Gene Ontologymeiotic recombination checkpoint1
GO:0034729
IDA, IMP
IEA
Genome Projecthistone H3-K79 methylation
GO:0034729
IDA, IMP
Gene Ontologyhistone H3-K79 methylation2
GO:0006301
IGI
Genome Projectpostreplication repair
GO:0006301
IGI
Gene Ontologypostreplication repair3
GO:0000725
IMP, IGI
Genome Projectrecombinational repair
GO:0000725
IMP, IGI
Gene Ontologyrecombinational repair3
GO:0006289
IMP, IGI
Genome Projectnucleotide-excision repair
GO:0006289
IMP, IGI
Gene Ontologynucleotide-excision repair3
GO:0000077
IMP, IGI
IEA
Genome ProjectDNA damage checkpoint
GO:0000077
IMP, IGI
Gene OntologyDNA damage checkpoint3
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0070911
IMP
Genome Projectglobal genome nucleotide-excision repair
GO:0070911
IMP
Gene Ontologyglobal genome nucleotide-excision repair4
GO:0006348
IMP
IEA
Genome Projectchromatin silencing at telomere
GO:0006348
IMP
Gene Ontologychromatin silencing at telomere1
GO:0031573
IMP
Genome Projectintra-S DNA damage checkpoint
GO:0031573
IMP
Gene Ontologyintra-S DNA damage checkpoint5
GO:0044783
IMP
Genome ProjectG1 DNA damage checkpoint
GO:0044783
IMP
Gene OntologyG1 DNA damage checkpoint5
GO:2000677
IBA
Genome Projectregulation of transcription regulatory region DNA binding
GO:0051726
IEA
Genome Projectregulation of cell cycle
GO:0006281
IEA
Genome ProjectDNA repair
GO:0099114
IMP
Gene Ontologychromatin silencing at subtelomere6
GO:0031452
IMP
Gene Ontologynegative regulation of heterochromatin assembly6
GO:0006334
IDA
Gene Ontologynucleosome assembly7
GO:0043486
IMP
Gene Ontologyhistone exchange7
GO:0031325
IEA
PLAZA Integrative Orthologypositive regulation of cellular metabolic process ENSG00000104885
GO:0010646
IEA
PLAZA Integrative Orthologyregulation of cell communication ENSG00000104885
GO:0031047
IEA
PLAZA Integrative Orthologygene silencing by RNA FBgn0264495
GO:0030154
IEA
PLAZA Integrative Orthologycell differentiation FBgn0264495
GO:0046331
IEA
PLAZA Integrative Orthologylateral inhibition FBgn0264495
GO:0045165
IEA
PLAZA Integrative Orthologycell fate commitment FBgn0264495
GO:0010604
IEA
PLAZA Integrative Orthologypositive regulation of macromolecule metabolic process ENSG00000104885
GO:0031328
IEA
PLAZA Integrative Orthologypositive regulation of cellular biosynthetic process ENSG00000104885
GO:1903508
IEA
PLAZA Integrative Orthologypositive regulation of nucleic acid-templated transcription ENSG00000104885
GO:0010608
IEA
PLAZA Integrative Orthologyposttranscriptional regulation of gene expression FBgn0264495
GO:0006357
IEA
PLAZA Integrative Orthologyregulation of transcription by RNA polymerase II ENSG00000104885
GO:0048869
IEA
PLAZA Integrative Orthologycellular developmental process FBgn0264495
GO:0042127
IEA
PLAZA Integrative Orthologyregulation of cell proliferation ENSG00000104885
GO:0007165
IEA
PLAZA Integrative Orthologysignal transduction ENSG00000104885
GO:0032502
IEA
PLAZA Integrative Orthologydevelopmental process FBgn0264495
GO:0010557
IEA
PLAZA Integrative Orthologypositive regulation of macromolecule biosynthetic process ENSG00000104885
GO:0048583
IEA
PLAZA Integrative Orthologyregulation of response to stimulus ENSG00000104885
GO:0060148
IEA
PLAZA Integrative Orthologypositive regulation of posttranscriptional gene silencing FBgn0264495
GO:0060147
IEA
PLAZA Integrative Orthologyregulation of posttranscriptional gene silencing FBgn0264495
GO:0045944
IEA
PLAZA Integrative Orthologypositive regulation of transcription by RNA polymerase II ENSG00000104885
GO:0008284
IEA
PLAZA Integrative Orthologypositive regulation of cell proliferation ENSG00000104885
GO:0009891
IEA
PLAZA Integrative Orthologypositive regulation of biosynthetic process ENSG00000104885
GO:1902531
IEA
PLAZA Integrative Orthologyregulation of intracellular signal transduction ENSG00000104885
GO:0007154
IEA
PLAZA Integrative Orthologycell communication ENSG00000104885
GO:0009893
IEA
PLAZA Integrative Orthologypositive regulation of metabolic process ENSG00000104885
GO:0008283
IEA
PLAZA Integrative Orthologycell proliferation ENSG00000104885
GO:0048096
IEA
PLAZA Integrative Orthologychromatin-mediated maintenance of transcription FBgn0264495
GO:0016441
IEA
PLAZA Integrative Orthologyposttranscriptional gene silencing FBgn0264495
GO:0023052
IEA
PLAZA Integrative Orthologysignaling ENSG00000104885
GO:0010628
IEA
PLAZA Integrative Orthologypositive regulation of gene expression ENSG00000104885
GO:0051254
IEA
PLAZA Integrative Orthologypositive regulation of RNA metabolic process ENSG00000104885
GO:0023051
IEA
PLAZA Integrative Orthologyregulation of signaling ENSG00000104885
GO:0097696
IEA
PLAZA Integrative OrthologySTAT cascade ENSG00000104885
GO:0009966
IEA
PLAZA Integrative Orthologyregulation of signal transduction ENSG00000104885
GO:0046425
IEA
PLAZA Integrative Orthologyregulation of JAK-STAT cascade ENSG00000104885
GO:0007267
IEA
PLAZA Integrative Orthologycell-cell signaling FBgn0264495
GO:0035195
IEA
PLAZA Integrative Orthologygene silencing by miRNA FBgn0264495
GO:0035194
IEA
PLAZA Integrative Orthologyposttranscriptional gene silencing by RNA FBgn0264495
GO:0045815
IEA
PLAZA Integrative Orthologypositive regulation of gene expression, epigenetic FBgn0264495
GO:0045935
IEA
PLAZA Integrative Orthologypositive regulation of nucleobase-containing compound metabolic process ENSG00000104885
GO:1902680
IEA
PLAZA Integrative Orthologypositive regulation of RNA biosynthetic process ENSG00000104885
GO:0035556
IEA
PLAZA Integrative Orthologyintracellular signal transduction ENSG00000104885
GO:0032200
IEA
PLAZA Integrative Orthologytelomere organization ENSG00000104885
GO:2000637
IEA
PLAZA Integrative Orthologypositive regulation of gene silencing by miRNA FBgn0264495
GO:0045893
IEA
PLAZA Integrative Orthologypositive regulation of transcription, DNA-templated ENSG00000104885
GO:0048522
IEA
PLAZA Integrative Orthologypositive regulation of cellular process ENSG00000104885
GO:0030702
IEA
PLAZA Integrative Orthologychromatin silencing at centromere FBgn0264495
GO:0060964
IEA
PLAZA Integrative Orthologyregulation of gene silencing by miRNA FBgn0264495
GO:0007259
IEA
PLAZA Integrative OrthologyJAK-STAT cascade ENSG00000104885
GO:0048518
IEA
PLAZA Integrative Orthologypositive regulation of biological process ENSG00000104885
GO:0060968
IEA
PLAZA Integrative Orthologyregulation of gene silencing FBgn0264495
GO:0045168
IEA
PLAZA Integrative Orthologycell-cell signaling involved in cell fate commitment FBgn0264495
GO:0060966
IEA
PLAZA Integrative Orthologyregulation of gene silencing by RNA FBgn0264495
GO:0051173
IEA
PLAZA Integrative Orthologypositive regulation of nitrogen compound metabolic process ENSG00000104885
GO:0006366
IEA
PLAZA Integrative Orthologytranscription by RNA polymerase II ENSG00000104885
GO:1904892
IEA
PLAZA Integrative Orthologyregulation of STAT cascade ENSG00000104885

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0031151
IDA, IMP
IEA
Genome Projecthistone methyltransferase activity (H3-K79 specific)
GO:0031151
IDA, IMP
Gene Ontologyhistone methyltransferase activity (H3-K79 specific)2 8
GO:0031493
IDA
IEA
Genome Projectnucleosomal histone binding
GO:0031493
IDA
Gene Ontologynucleosomal histone binding8
GO:0018024
IEA
Genome Projecthistone-lysine N-methyltransferase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0008168
IEA
Genome Projectmethyltransferase activity
GO:0003677
IEA
Genome ProjectDNA binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
IEA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus1
GO:0000781
IEA
Genome Projectchromosome, telomeric region
GO:0070013
IEA
PLAZA Integrative Orthologyintracellular organelle lumen ENSG00000104885
GO:1990234
IEA
PLAZA Integrative Orthologytransferase complex FBgn0264495
GO:0035097
IEA
PLAZA Integrative Orthologyhistone methyltransferase complex FBgn0264495
GO:0044428
IEA
PLAZA Integrative Orthologynuclear part ENSG00000104885
GO:0031974
IEA
PLAZA Integrative Orthologymembrane-enclosed lumen ENSG00000104885
GO:0005654
IEA
PLAZA Integrative Orthologynucleoplasm ENSG00000104885
GO:1902494
IEA
PLAZA Integrative Orthologycatalytic complex FBgn0264495
GO:0032991
IEA
PLAZA Integrative Orthologyprotein-containing complex ENSG00000104885
GO:0031981
IEA
PLAZA Integrative Orthologynuclear lumen ENSG00000104885
GO:0044451
IEA
PLAZA Integrative Orthologynucleoplasm part FBgn0264495
GO:0043233
IEA
PLAZA Integrative Orthologyorganelle lumen ENSG00000104885
GO:0034708
IEA
PLAZA Integrative Orthologymethyltransferase complex FBgn0264495

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR021162Histone H3-K79 methyltransferase, fungi
IPR025789Histone-lysine N-methyltransferase DOT1 domain
IPR029063S-adenosyl-L-methionine-dependent methyltransferase
IPR030445Histone H3-K79 methyltransferase

No MapMan annotations defined for this gene.
KeggID Description
K11427DOT1L, DOT1; histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]
No chloroplast target sequence found.