Gene: YDL077C (Saccharomyces cerevisiae strain S288C)

Overview top

Gene Identifier
YDL077C
Transcript Identifier
YDL077C
Gene Type
Coding gene
Location
IV : 316971-320120 : negative

Family Information

Homologous gene family
HOM02SEM008483
(10 genes in 9 species)
specific family

Descriptions

gene_descr
Subunit of the HOPS endocytic tethering complex; vacuole membrane protein that functions as a Rab GTPase effector, interacting with both GTP- and GDP-bound conformations of Ypt7p, facilitating tethering and promoting several membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking

Identifiers

Type Value
pidYDL077C
UniprotQ07468
RefSeq_mRNANM_001180136.1
EMBLBK006938
EMBLD83058
EMBLZ74125
SGDS000002235

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:1904263
IMP, IGI
Genome Projectpositive regulation of TORC1 signaling
GO:1904263
IMP, IGI
Gene Ontologypositive regulation of TORC1 signaling1
GO:0042144
IDA, IMP
Genome Projectvacuole fusion, non-autophagic
GO:0042144
IDA, IMP
Gene Ontologyvacuole fusion, non-autophagic2
GO:0097576
IEA
Genome Projectvacuole fusion
GO:0007033
IMP
Genome Projectvacuole organization
GO:0007033
IMP
Gene Ontologyvacuole organization3
GO:0034727
IMP
Genome Projectpiecemeal microautophagy of the nucleus
GO:0034727
IMP
Gene Ontologypiecemeal microautophagy of the nucleus4
GO:0015031
IEA
Genome Projectprotein transport
GO:0006810
IEA
Genome Projecttransport
GO:0032889
IDA
Genome Projectregulation of vacuole fusion, non-autophagic
GO:0032889
IDA
Gene Ontologyregulation of vacuole fusion, non-autophagic5
GO:0099022
IDA
Genome Projectvesicle tethering
GO:0099022
IDA
Gene Ontologyvesicle tethering6
GO:0016192
IMP
IEA
Genome Projectvesicle-mediated transport
GO:0016192
IMP
Gene Ontologyvesicle-mediated transport7
GO:0006886
IEA
Genome Projectintracellular protein transport
GO:0035542
IDA
Genome Projectregulation of SNARE complex assembly
GO:0035542
IDA
Gene Ontologyregulation of SNARE complex assembly5
GO:0043547
IEA
Genome Projectpositive regulation of GTPase activity
GO:0030154
IEA
PLAZA Integrative Orthologycell differentiation FBgn0038593
GO:0044271
IEA
PLAZA Integrative Orthologycellular nitrogen compound biosynthetic process ENSG00000135966
GO:0048869
IEA
PLAZA Integrative Orthologycellular developmental process FBgn0038593
GO:0022411
IEA
PLAZA Integrative Orthologycellular component disassembly FBgn0038593
GO:0048468
IEA
PLAZA Integrative Orthologycell development FBgn0038593
GO:0007167
IEA
PLAZA Integrative Orthologyenzyme linked receptor protein signaling pathway ENSG00000135966
GO:0007166
IEA
PLAZA Integrative Orthologycell surface receptor signaling pathway ENSG00000135966
GO:0006355
IEA
PLAZA Integrative Orthologyregulation of transcription, DNA-templated ENSG00000135966
GO:1901576
IEA
PLAZA Integrative Orthologyorganic substance biosynthetic process ENSG00000135966
GO:0007041
IEA
PLAZA Integrative Orthologylysosomal transport ENSG00000166887
GO:0006351
IEA
PLAZA Integrative Orthologytranscription, DNA-templated ENSG00000135966
GO:0032501
IEA
PLAZA Integrative Orthologymulticellular organismal process FBgn0038593
GO:0034645
IEA
PLAZA Integrative Orthologycellular macromolecule biosynthetic process ENSG00000135966
GO:0140057
IEA
PLAZA Integrative Orthologyvacuole-mitochondria membrane tethering SPAC23H4.14
GO:0032984
IEA
PLAZA Integrative Orthologyprotein-containing complex disassembly FBgn0038593
GO:0140056
IEA
PLAZA Integrative Orthologyorganelle localization by membrane tethering SPAC23H4.14
GO:0032502
IEA
PLAZA Integrative Orthologydevelopmental process FBgn0038593
GO:0034641
IEA
PLAZA Integrative Orthologycellular nitrogen compound metabolic process ENSG00000135966
GO:0033554
IEA
PLAZA Integrative Orthologycellular response to stress FBgn0038593
GO:0010556
IEA
PLAZA Integrative Orthologyregulation of macromolecule biosynthetic process ENSG00000135966
GO:0098876
IEA
PLAZA Integrative Orthologyvesicle-mediated transport to the plasma membrane ENSG00000166887
GO:0009605
IEA
PLAZA Integrative Orthologyresponse to external stimulus FBgn0038593
GO:0032989
IEA
PLAZA Integrative Orthologycellular component morphogenesis FBgn0038593
GO:0044260
IEA
PLAZA Integrative Orthologycellular macromolecule metabolic process ENSG00000135966
GO:0043170
IEA
PLAZA Integrative Orthologymacromolecule metabolic process ENSG00000135966
GO:0048858
IEA
PLAZA Integrative Orthologycell projection morphogenesis FBgn0038593
GO:1903506
IEA
PLAZA Integrative Orthologyregulation of nucleic acid-templated transcription ENSG00000135966
GO:0048699
IEA
PLAZA Integrative Orthologygeneration of neurons FBgn0038593
GO:0009058
IEA
PLAZA Integrative Orthologybiosynthetic process ENSG00000135966
GO:0009059
IEA
PLAZA Integrative Orthologymacromolecule biosynthetic process ENSG00000135966
GO:0007034
IEA
PLAZA Integrative Orthologyvacuolar transport ENSG00000166887
GO:1902774
IEA
PLAZA Integrative Orthologylate endosome to lysosome transport ENSG00000166887
GO:0042594
IEA
PLAZA Integrative Orthologyresponse to starvation FBgn0038593
GO:0048856
IEA
PLAZA Integrative Orthologyanatomical structure development FBgn0038593
GO:0007399
IEA
PLAZA Integrative Orthologynervous system development FBgn0038593
GO:0032990
IEA
PLAZA Integrative Orthologycell part morphogenesis FBgn0038593
GO:0007275
IEA
PLAZA Integrative Orthologymulticellular organism development FBgn0038593
GO:0019438
IEA
PLAZA Integrative Orthologyaromatic compound biosynthetic process ENSG00000135966
GO:0031667
IEA
PLAZA Integrative Orthologyresponse to nutrient levels FBgn0038593
GO:0034654
IEA
PLAZA Integrative Orthologynucleobase-containing compound biosynthetic process ENSG00000135966
GO:0010467
IEA
PLAZA Integrative Orthologygene expression ENSG00000135966
GO:0010468
IEA
PLAZA Integrative Orthologyregulation of gene expression ENSG00000135966
GO:0006807
IEA
PLAZA Integrative Orthologynitrogen compound metabolic process ENSG00000135966
GO:0048731
IEA
PLAZA Integrative Orthologysystem development FBgn0038593
GO:0031669
IEA
PLAZA Integrative Orthologycellular response to nutrient levels FBgn0038593
GO:0007219
IEA
PLAZA Integrative OrthologyNotch signaling pathway FBgn0038593
GO:0031668
IEA
PLAZA Integrative Orthologycellular response to extracellular stimulus FBgn0038593
GO:0071560
IEA
PLAZA Integrative Orthologycellular response to transforming growth factor beta stimulus ENSG00000135966
GO:0009889
IEA
PLAZA Integrative Orthologyregulation of biosynthetic process ENSG00000135966
GO:0006139
IEA
PLAZA Integrative Orthologynucleobase-containing compound metabolic process ENSG00000135966
GO:0044249
IEA
PLAZA Integrative Orthologycellular biosynthetic process ENSG00000135966
GO:0042221
IEA
PLAZA Integrative Orthologyresponse to chemical ENSG00000135966
GO:0030182
IEA
PLAZA Integrative Orthologyneuron differentiation FBgn0038593
GO:2001141
IEA
PLAZA Integrative Orthologyregulation of RNA biosynthetic process ENSG00000135966
GO:0090304
IEA
PLAZA Integrative Orthologynucleic acid metabolic process ENSG00000135966
GO:0070887
IEA
PLAZA Integrative Orthologycellular response to chemical stimulus ENSG00000135966
GO:0044238
IEA
PLAZA Integrative Orthologyprimary metabolic process ENSG00000135966
GO:0051171
IEA
PLAZA Integrative Orthologyregulation of nitrogen compound metabolic process ENSG00000135966
GO:0007178
IEA
PLAZA Integrative Orthologytransmembrane receptor protein serine/threonine kinase signaling pathway ENSG00000135966
GO:0007179
IEA
PLAZA Integrative Orthologytransforming growth factor beta receptor signaling pathway ENSG00000135966
GO:0009991
IEA
PLAZA Integrative Orthologyresponse to extracellular stimulus FBgn0038593
GO:0120039
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection morphogenesis FBgn0038593
GO:0120036
IEA
PLAZA Integrative Orthologyplasma membrane bounded cell projection organization FBgn0038593
GO:0031323
IEA
PLAZA Integrative Orthologyregulation of cellular metabolic process ENSG00000135966
GO:0080090
IEA
PLAZA Integrative Orthologyregulation of primary metabolic process ENSG00000135966
GO:0071704
IEA
PLAZA Integrative Orthologyorganic substance metabolic process ENSG00000135966
GO:0031326
IEA
PLAZA Integrative Orthologyregulation of cellular biosynthetic process ENSG00000135966
GO:0032774
IEA
PLAZA Integrative OrthologyRNA biosynthetic process ENSG00000135966
GO:0097352
IEA
PLAZA Integrative Orthologyautophagosome maturation FBgn0038593
GO:0006950
IEA
PLAZA Integrative Orthologyresponse to stress FBgn0038593
GO:0009267
IEA
PLAZA Integrative Orthologycellular response to starvation FBgn0038593
GO:0048666
IEA
PLAZA Integrative Orthologyneuron development FBgn0038593
GO:0008333
IEA
PLAZA Integrative Orthologyendosome to lysosome transport ENSG00000166887
GO:0031175
IEA
PLAZA Integrative Orthologyneuron projection development FBgn0038593
GO:0060255
IEA
PLAZA Integrative Orthologyregulation of macromolecule metabolic process ENSG00000135966
GO:0071559
IEA
PLAZA Integrative Orthologyresponse to transforming growth factor beta ENSG00000135966
GO:0016236
IEA
PLAZA Integrative Orthologymacroautophagy FBgn0038593
GO:0019222
IEA
PLAZA Integrative Orthologyregulation of metabolic process ENSG00000135966
GO:0016197
IEA
PLAZA Integrative Orthologyendosomal transport ENSG00000166887
GO:0018130
IEA
PLAZA Integrative Orthologyheterocycle biosynthetic process ENSG00000135966
GO:0071310
IEA
PLAZA Integrative Orthologycellular response to organic substance ENSG00000135966
GO:0016070
IEA
PLAZA Integrative OrthologyRNA metabolic process ENSG00000135966
GO:0046483
IEA
PLAZA Integrative Orthologyheterocycle metabolic process ENSG00000135966
GO:0009653
IEA
PLAZA Integrative Orthologyanatomical structure morphogenesis FBgn0038593
GO:0048812
IEA
PLAZA Integrative Orthologyneuron projection morphogenesis FBgn0038593
GO:1901362
IEA
PLAZA Integrative Orthologyorganic cyclic compound biosynthetic process ENSG00000135966
GO:1901360
IEA
PLAZA Integrative Orthologyorganic cyclic compound metabolic process ENSG00000135966
GO:0019219
IEA
PLAZA Integrative Orthologyregulation of nucleobase-containing compound metabolic process ENSG00000135966
GO:0097659
IEA
PLAZA Integrative Orthologynucleic acid-templated transcription ENSG00000135966
GO:0034058
IEA
PLAZA Integrative Orthologyendosomal vesicle fusion ENSG00000166887
GO:0051252
IEA
PLAZA Integrative Orthologyregulation of RNA metabolic process ENSG00000135966
GO:0009719
IEA
PLAZA Integrative Orthologyresponse to endogenous stimulus ENSG00000135966
GO:0071363
IEA
PLAZA Integrative Orthologycellular response to growth factor stimulus ENSG00000135966
GO:0006725
IEA
PLAZA Integrative Orthologycellular aromatic compound metabolic process ENSG00000135966
GO:0000902
IEA
PLAZA Integrative Orthologycell morphogenesis FBgn0038593
GO:0008593
IEA
PLAZA Integrative Orthologyregulation of Notch signaling pathway FBgn0038593
GO:0010033
IEA
PLAZA Integrative Orthologyresponse to organic substance ENSG00000135966
GO:2000112
IEA
PLAZA Integrative Orthologyregulation of cellular macromolecule biosynthetic process ENSG00000135966
GO:0071496
IEA
PLAZA Integrative Orthologycellular response to external stimulus FBgn0038593
GO:0071495
IEA
PLAZA Integrative Orthologycellular response to endogenous stimulus ENSG00000135966
GO:1990126
IEA
PLAZA Integrative Orthologyretrograde transport, endosome to plasma membrane ENSG00000166887
GO:0022008
IEA
PLAZA Integrative Orthologyneurogenesis FBgn0038593
GO:0030030
IEA
PLAZA Integrative Orthologycell projection organization FBgn0038593
GO:0022406
IEA
PLAZA Integrative Orthologymembrane docking SPAC23H4.14
GO:0070848
IEA
PLAZA Integrative Orthologyresponse to growth factor ENSG00000135966

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0035091
IDA
Genome Projectphosphatidylinositol binding
GO:0035091
IDA
Gene Ontologyphosphatidylinositol binding8
GO:0017137
IPI
Genome ProjectRab GTPase binding
GO:0017137
IPI
Gene OntologyRab GTPase binding9 10 11 12
GO:0005088
IDA
Genome ProjectRas guanyl-nucleotide exchange factor activity
GO:0005088
IDA
Gene OntologyRas guanyl-nucleotide exchange factor activity1
GO:0046332
IEA
PLAZA Integrative OrthologySMAD binding ENSG00000135966
GO:0005160
IEA
PLAZA Integrative Orthologytransforming growth factor beta receptor binding ENSG00000135966
GO:0005102
IEA
PLAZA Integrative Orthologysignaling receptor binding ENSG00000135966
GO:0005126
IEA
PLAZA Integrative Orthologycytokine receptor binding ENSG00000135966

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000329
IDA
Genome Projectfungal-type vacuole membrane
GO:0000329
IDA
Gene Ontologyfungal-type vacuole membrane1 3 13
GO:0030897
IPI
IEA
Genome ProjectHOPS complex
GO:0030897
IPI
Gene OntologyHOPS complex2
GO:1990816
IDA
Genome Projectvacuole-mitochondrion membrane contact site
GO:1990816
IDA
Gene Ontologyvacuole-mitochondrion membrane contact site14 15
GO:0000324
IDA
Genome Projectfungal-type vacuole
GO:0000324
IDA
Gene Ontologyfungal-type vacuole16
GO:0005774
IEA
Genome Projectvacuolar membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0005773
IEA
Genome Projectvacuole
GO:0012505
IEA
PLAZA Integrative Orthologyendomembrane system ENSG00000166887
GO:0055044
IEA
PLAZA Integrative Orthologysymplast AT4G36630
GO:0097708
IEA
PLAZA Integrative Orthologyintracellular vesicle ENSG00000166887
GO:0031410
IEA
PLAZA Integrative Orthologycytoplasmic vesicle ENSG00000166887
GO:0005768
IEA
PLAZA Integrative Orthologyendosome ENSG00000166887
GO:0005769
IEA
PLAZA Integrative Orthologyearly endosome ENSG00000135966
GO:0005770
IEA
PLAZA Integrative Orthologylate endosome ENSG00000166887
GO:0030054
IEA
PLAZA Integrative Orthologycell junction AT4G36630
GO:0005829
IEA
PLAZA Integrative Orthologycytosol SPAC23H4.14
GO:0009506
IEA
PLAZA Integrative Orthologyplasmodesma AT4G36630
GO:0010008
IEA
PLAZA Integrative Orthologyendosome membrane ENSG00000166887
GO:0000325
IEA
PLAZA Integrative Orthologyplant-type vacuole AT4G36630
GO:0031982
IEA
PLAZA Integrative Orthologyvesicle ENSG00000166887
GO:0005911
IEA
PLAZA Integrative Orthologycell-cell junction AT4G36630
GO:0031902
IEA
PLAZA Integrative Orthologylate endosome membrane ENSG00000166887
GO:0005634
IEA
PLAZA Integrative Orthologynucleus SPAC23H4.14
GO:0005764
IEA
PLAZA Integrative Orthologylysosome ENSG00000166887
GO:0005765
IEA
PLAZA Integrative Orthologylysosomal membrane ENSG00000166887
GO:0044440
IEA
PLAZA Integrative Orthologyendosomal part ENSG00000166887
GO:0009705
IEA
PLAZA Integrative Orthologyplant-type vacuole membrane AT4G36630
GO:0044433
IEA
PLAZA Integrative Orthologycytoplasmic vesicle part ENSG00000166887

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000547Clathrin, heavy chain/VPS, 7-fold repeat
IPR011990Tetratricopeptide-like helical domain superfamily
IPR019452Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 1
IPR019453Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 2
IPR032914Vam6/VPS39/TRAP1 family

No MapMan annotations defined for this gene.
No Kegg annotations defined for this gene.
No chloroplast target sequence found.