Gene: WBGene00000418 (Caenorhabditis elegans)

Overview top

Gene Identifier
WBGene00000418
Transcript Identifier
C35D10.9b
Gene Type
Coding gene
Location
III : 4852325-4854957 : positive

Family Information

Homologous gene family
HOM02SEM084724
(orphan gene)
specific family

Descriptions

gene_descr
Caenorhabditis elegans Protein CED-4, isoform a (ced-4) mRNA, complete cds.

Identifiers

Type Value
pidC35D10.9b
UniprotP30429
RefSeq_mRNANM_001026032.1
EMBLFO080789
EMBLX69016

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0008219
IEA
Genome Projectcell death
GO:0006915
IMP
IEA
Genome Projectapoptotic process
GO:0006915
IMP, IGI
Gene Ontologyapoptotic process1 2 3
GO:2001056
IDA
Genome Projectpositive regulation of cysteine-type endopeptidase activity
GO:2001056
IDA
Gene Ontologypositive regulation of cysteine-type endopeptidase activity4
GO:1902742
IMP
Genome Projectapoptotic process involved in development
GO:1902742
IMP
Gene Ontologyapoptotic process involved in development5
GO:0048598
IGI
Genome Projectembryonic morphogenesis
GO:0048598
IGI
Gene Ontologyembryonic morphogenesis6
GO:0043281
IDA
Genome Projectregulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281
IDA
Gene Ontologyregulation of cysteine-type endopeptidase activity involved in apoptotic process7
GO:0043066
IDA
Genome Projectnegative regulation of apoptotic process
GO:0043066
IDA
Gene Ontologynegative regulation of apoptotic process8
GO:0043065
IDA, IMP
Genome Projectpositive regulation of apoptotic process
GO:0043065
IDA, IMP
Gene Ontologypositive regulation of apoptotic process7 8 9
GO:0042981
IEA
Genome Projectregulation of apoptotic process
GO:0030155
IMP
Genome Projectregulation of cell adhesion
GO:0030155
IMP
Gene Ontologyregulation of cell adhesion5
GO:0010954
IDA
Genome Projectpositive regulation of protein processing
GO:0010954
IDA
Gene Ontologypositive regulation of protein processing10 11
GO:0009792
IGI
Genome Projectembryo development ending in birth or egg hatching
GO:0009792
IGI
Gene Ontologyembryo development ending in birth or egg hatching12
GO:0008635
IBA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0008361
IGI
Genome Projectregulation of cell size
GO:0008361
IGI
Gene Ontologyregulation of cell size13
GO:0006919
IDA
Genome Projectactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006919
IDA, IMP
Gene Ontologyactivation of cysteine-type endopeptidase activity involved in apoptotic process11 14 15
GO:1905808
IMP, IGI
Gene Ontologypositive regulation of synapse pruning16
GO:1904747
IMP, IGI
Gene Ontologypositive regulation of apoptotic process involved in development17
GO:0097202
IMP
Gene Ontologyactivation of cysteine-type endopeptidase activity18
GO:0051289
IDA
Gene Ontologyprotein homotetramerization10
GO:0050829
IMP
Gene Ontologydefense response to Gram-negative bacterium3
GO:0046716
IGI
Gene Ontologymuscle cell cellular homeostasis19
GO:0031647
IGI
Gene Ontologyregulation of protein stability19
GO:0040034
IGI
Gene Ontologyregulation of development, heterochronic20
GO:0030042
IMP
Gene Ontologyactin filament depolymerization16

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0061133
IDA
Genome Projectendopeptidase activator activity
GO:0061133
IDA
Gene Ontologyendopeptidase activator activity10
GO:0051434
IPI
Genome ProjectBH3 domain binding
GO:0051434
IPI
Gene OntologyBH3 domain binding7
GO:0051432
IPI
Genome ProjectBH1 domain binding
GO:0051432
IPI
Gene OntologyBH1 domain binding7
GO:0043531
IEA
Genome ProjectADP binding
GO:0016505
IDA
Genome Projectpeptidase activator activity involved in apoptotic process
GO:0016505
IDA
Gene Ontologypeptidase activator activity involved in apoptotic process4
GO:0008656
IDA
IBA
Genome Projectcysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008656
IDA, IMP
Gene Ontologycysteine-type endopeptidase activator activity involved in apoptotic process11 14 18
GO:0005524
IDA
IEA
Genome ProjectATP binding
GO:0005524
IDA
Gene OntologyATP binding4 10 21
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IPI
Gene Ontologyprotein binding2 7 10 22 23 24 25 26 27 28 29 30 31 32 33
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0089720
IPI
Gene Ontologycaspase binding18

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0048471
IDA
Genome Projectperinuclear region of cytoplasm
GO:0048471
IDA
Gene Ontologyperinuclear region of cytoplasm7 24 34 35
GO:0016020
IDA
Genome Projectmembrane
GO:0016020
IDA
Gene Ontologymembrane24
GO:0005829
IDA
Genome Projectcytosol
GO:0005829
IDA
Gene Ontologycytosol7 24
GO:0005739
IDA
IEA
Genome Projectmitochondrion
GO:0005739
IDA
Gene Ontologymitochondrion34
GO:0005634
IDA
Genome Projectnucleus
GO:0005634
IDA
Gene Ontologynucleus34
GO:0008303
IMP
Gene Ontologycaspase complex18

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001315CARD domain
IPR002182NB-ARC
IPR011029Death-like domain superfamily
IPR011991ArsR-like helix-turn-helix domain
IPR016854Apoptosis regulator, Ced-4
IPR027417P-loop containing nucleoside triphosphate hydrolase

No MapMan annotations defined for this gene.
KeggID Description
K02084APAF1; apoptotic protease-activating factor
K20105CED-4; cell death protein 4
No chloroplast target sequence found.